Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Wilton B"'
Autor:
Sommer Holmes, Hui Li, Xiaoying Shen, Mitchell Martin, Ryan Tuck, Yue Chen, Elena E. Giorgi, Hélène Fradin Kirshner, Madison Berry, Elizabeth Van Italie, Sravani Venkatayogi, Joshua S. Martin Beem, Robert J. Edwards, Katayoun Mansouri, Ajay Singh, Cindy Kuykendall, Thaddeus Gurley, M. Anthony Moody, Nicole DeNayer, Todd Demarco, Thomas N. Denny, Yunfei Wang, Tyler D. Evangelous, John T. Clinton, Bhavna Hora, Kshitij Wagh, Michael S. Seaman, Kevin O. Saunders, Nicholas Solomotis, Johnathan Misamore, Mark G. Lewis, Kevin Wiehe, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract The details of the pediatric immune system that supports induction of antibodies capable of neutralizing geographically-diverse or heterologous HIV-1 is currently unclear. Here we explore the pediatric immune environment in neonatal macaque
Externí odkaz:
https://doaj.org/article/8a02ed03cb6c4c07b1bf35351c55e38c
Publikováno v:
Viruses, Vol 16, Iss 7, p 1014 (2024)
We recently demonstrated that Simian–HIV (SHIV)-infected neonate rhesus macaques (RMs) generated heterologous HIV-1 neutralizing antibodies (NAbs) with broadly-NAb (bNAb) characteristics at a higher frequency compared with their corresponding dam.
Externí odkaz:
https://doaj.org/article/12cfb65587624ee0bc0ebbb0487de846
Autor:
Bhavna Hora, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, Andrew N. Macintyre, Aria Arus-Altuz, Shuyi Wang, Ajay Singh, Chengyan Zhao, Nicole De Naeyer, Todd DeMarco, Cindy Kuykendall, Thaddeus Gurley, Kevin O. Saunders, Thomas Denny, M. Anthony Moody, John Misamore, Mark G. Lewis, Kevin Wiehe, Derek W. Cain, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112255- (2023)
Summary: Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for t
Externí odkaz:
https://doaj.org/article/7dce7418af584710aa80977788fdbcd6
Autor:
Qifeng Han, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, Regina W. Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J. Wiehe, Steven Reed, Christopher B. Fox, Wes Rountree, Nathan A. Vandergrift, Yunfei Wang, Laura L. Sutherland, Sampa Santra, M. Anthony Moody, Sallie R. Permar, Georgia D. Tomaras, Mark G. Lewis, Koen K.A. Van Rompay, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1553-1569.e6 (2020)
Summary: HIV-1-infected infants develop broadly neutralizing antibodies (bnAbs) more rapidly than adults, suggesting differences in the neonatal versus adult responses to the HIV-1 envelope (Env). Here, trimeric forms of HIV-1 Env immunogens elicit i
Externí odkaz:
https://doaj.org/article/e0ebd789a52f48e3b4e0a32d2972f0a6
Autor:
Wilton B. Williams, Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Thomas B. Kepler, Akshaya Ramesh, Kevin Wiehe, James A. Holland, Todd Bradley, Nathan Vandergrift, Kevin O. Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori, David C. Montefiori, Mark Louder, Amanda Eaton, Sampa Santra, Richard Scearce, Laura Sutherland, Amanda Newman, Hilary Bouton-Verville, Cindy Bowman, Howard Bomze, Feng Gao, Dawn J. Marshall, John F. Whitesides, Xiaoyan Nie, Garnett Kelsoe, Steven G. Reed, Christopher B. Fox, Kim Clary, Marguerite Koutsoukos, David Franco, John R. Mascola, Stephen C. Harrison, Barton F. Haynes, Laurent Verkoczy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnA
Externí odkaz:
https://doaj.org/article/69f91741f8e94cd5827c2664a8377d65
Autor:
Celia C LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O Saunders, S Munir Alam, Mattia Bonsignori, Mario J Borgnia, Quentin J Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B Williams, James Peacock, Haili Tang, Lautaro G Perez, Robert J Edwards, Thomas B Kepler, Bette T Korber, Peter D Kwong, John R Mascola, Priyamvada Acharya, Barton F Haynes, David C Montefiori
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008200 (2019)
[This corrects the article DOI: 10.1371/journal.ppat.1008026.].
Externí odkaz:
https://doaj.org/article/d77fba0b5ed4480abb35732f5282465d
Autor:
Celia C LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O Saunders, S Munir Alam, Mattia Bonsignori, Mario J Borgnia, Quentin J Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B Williams, James Peacock, Haili Tang, Lautaro G Perez, Robert J Edwards, Thomas B Kepler, Bette T Korber, Peter D Kwong, John R Mascola, Priyamvada Acharya, Barton F Haynes, David C Montefiori
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008026 (2019)
The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines. The CH235 lineage (VH1-46) of CD4bs bnAbs is particularly attr
Externí odkaz:
https://doaj.org/article/3844ced64c8c413cb77bd6f0f21b0bcd
Autor:
Williams, Wilton B., Alam, S. Munir, Ofek, Gilad, Erdmann, Nathaniel, Montefiori, David C., Seaman, Michael S., Wagh, Kshitij, Korber, Bette, Edwards, Robert J., Mansouri, Katayoun, Eaton, Amanda, Cain, Derek W., Martin, Mitchell, Hwang, JongIn, Arus-Altuz, Aria, Lu, Xiaozhi, Cai, Fangping, Jamieson, Nolan, Parks, Robert, Barr, Maggie, Foulger, Andrew, Anasti, Kara, Patel, Parth, Sammour, Salam, Parsons, Ruth J., Huang, Xiao, Lindenberger, Jared, Fetics, Susan, Janowska, Katarzyna, Niyongabo, Aurelie, Janus, Benjamin M., Astavans, Anagh, Fox, Christopher B., Mohanty, Ipsita, Evangelous, Tyler, Chen, Yue, Berry, Madison, Kirshner, Helene, Van Itallie, Elizabeth, Saunders, Kevin O., Wiehe, Kevin, Cohen, Kristen W., McElrath, M. Juliana, Corey, Lawrence, Acharya, Priyamvada, Walsh, Stephen R., Baden, Lindsey R., Haynes, Barton F.
Publikováno v:
In Cell 6 June 2024 187(12):2919-2934
Autor:
Wiehe, Kevin, Saunders, Kevin O., Stalls, Victoria, Cain, Derek W., Venkatayogi, Sravani, Martin Beem, Joshua S., Berry, Madison, Evangelous, Tyler, Henderson, Rory, Hora, Bhavna, Xia, Shi-Mao, Jiang, Chuancang, Newman, Amanda, Bowman, Cindy, Lu, Xiaozhi, Bryan, Mary E., Bal, Joena, Sanzone, Aja, Chen, Haiyan, Eaton, Amanda, Tomai, Mark A., Fox, Christopher B., Tam, Ying K., Barbosa, Christopher, Bonsignori, Mattia, Muramatsu, Hiromi, Alam, S. Munir, Montefiori, David C., Williams, Wilton B., Pardi, Norbert, Tian, Ming, Weissman, Drew, Alt, Frederick W., Acharya, Priyamvada, Haynes, Barton F.
Publikováno v:
In Cell Host & Microbe 8 May 2024 32(5):693-709
Autor:
Saunders, Kevin O., Counts, James, Thakur, Bhishem, Stalls, Victoria, Edwards, Robert, Manne, Kartik, Lu, Xiaozhi, Mansouri, Katayoun, Chen, Yue, Parks, Rob, Barr, Maggie, Sutherland, Laura, Bal, Joena, Havill, Nicholas, Chen, Haiyan, Machiele, Emily, Jamieson, Nolan, Hora, Bhavna, Kopp, Megan, Janowska, Katarzyna, Anasti, Kara, Jiang, Chuancang, Van Itallie, Elizabeth, Venkatayogi, Sravani, Eaton, Amanda, Henderson, Rory, Barbosa, Christopher, Alam, S. Munir, Santra, Sampa, Weissman, Drew, Moody, M. Anthony, Cain, Derek W., Tam, Ying K., Lewis, Mark, Williams, Wilton B., Wiehe, Kevin, Montefiori, David C., Acharya, Priyamvada, Haynes, Barton F.
Publikováno v:
In Cell 4 January 2024 187(1):79-94