Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Wilson X. Mai"'
Autor:
Elizabeth G. Fernandez, Wilson X. Mai, Kai Song, Nicholas A. Bayley, Jiyoon Kim, Henan Zhu, Marissa Pioso, Pauline Young, Cassidy L. Andrasz, Dimitri Cadet, Linda M. Liau, Gang Li, William H. Yong, Fausto J. Rodriguez, Scott J. Dixon, Andrew J. Souers, Jingyi Jessica Li, Thomas G. Graeber, Timothy F. Cloughesy, David A. Nathanson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dynam
Externí odkaz:
https://doaj.org/article/448c7d25de1847ae879892038cc09dad
Autor:
Christopher Tse, Nicholas Bayley, Elizabeth Fernandez, Wilson X. Mai, Timothy F. Cloughesy, Linda M. Liau, David Nathanson, Anthony Letai
Publikováno v:
Neuro Oncol
Resistance to apoptosis is a hallmark of cancer. However, the underlying molecular mechanisms of intrinsic-apoptotic resistance in glioblastoma (GBM) are largely unknown. Here we performed integrated molecular and functional characterization (via BH3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420bafb185a25951ea16a5857c5d4576
https://doi.org/10.1093/neuonc/noaa215.085
https://doi.org/10.1093/neuonc/noaa215.085
Autor:
Lisa Ta, Alex A. Dooraghi, Arion F. Chatziioannou, Michael E. Phelps, James R. Heath, Jungwoo Kim, Wilson X. Mai, Dazy Johnson, David Nathanson, Young Shik Shin
Publikováno v:
TECHNOLOGY. :172-178
The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose (18F-FDG). We report on an integrated microfluidics-chip/beta partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5104e6cc413cef7ca27f4ac083254559
https://doi.org/10.1142/s2339547815200058
https://doi.org/10.1142/s2339547815200058
Autor:
W Blake Gilmore, William H. Yong, Mitra Dehghan Harati, Jason T. Lee, David Nathanson, Wilson X. Mai, Jonathan Tsang, Harley I. Kornblum, Anthony Letai, Paul S. Mischel, Peter M. Clark, Brian Higgins, Steven J. Bensinger, Laura Gosa, Lisa Ta, P. Nagesh Rao, Timothy F. Cloughesy, Nicholas Bayley, Veerle W. Daniels
Publikováno v:
Nature medicine, vol 23, iss 11
Nature medicine
Nature medicine
Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b9bee8ebcdaa05f80023815d8f5955
https://escholarship.org/uc/item/423476tv
https://escholarship.org/uc/item/423476tv
Autor:
Anthony Letai, Wilson X. Mai, Nicholas Bayley, Timothy F. Cloughesy, Linda M. Liau, David Nathanson, Elizabeth Fernandez
Publikováno v:
Neuro Oncol
Conventional therapies (e.g., temozolomide (TMZ), Irradiation (IR)) transiently halt tumor growth of glioblastoma (GBM) but fail to induce cell death through apoptosis. Consequently, the inability to kill GBM tumor cells ultimately leads to disease p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3699d568821930d6091b733345fabe6
https://doi.org/10.1093/neuonc/noz175.166
https://doi.org/10.1093/neuonc/noz175.166
Autor:
Andre E. Nel, Haiyuan Zhang, Min Xue, Chong Hyun Chang, C. Jeffrey Brinker, Juyao Dong, Jeffrey I. Zink, Huan Meng, Wilson X. Mai, Yang Zhao, Zhaoxia Ji, Yu Shen Lin
Publikováno v:
ACS nano, vol 7, iss 11
Pancreatic ductal adenocarcinoma (PDAC) elicits a dense stromal response that blocks vascular access because of pericyte coverage of vascular fenestrations. In this way, the PDAC stroma contributes to chemotherapy resistance in addition to causing ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18fcd59a172d90a3dc47e9721bcafd4
https://doi.org/10.1021/nn404083m
https://doi.org/10.1021/nn404083m
Autor:
Xiang Wang, Min Xue, Yang Zhao, Huan Meng, Sijie Lin, Wilson X. Mai, Jeffrey I. Zink, Andre E. Nel, Haiyuan Zhang, Tian Xia, Zhaoxia Ji
Publikováno v:
ACS Nano. 7:994-1005
We used a multi-functional mesoporous silica nanoparticle (MSNP) carrier to overcome doxorubicin (Dox) resistance in a multidrug resistant (MDR) human breast cancer xenograft by co-delivering Dox and siRNA that targets the P-glycoprotein (Pgp) drug e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534f47269e91964e1cfa45a924f9c4b0
https://doi.org/10.1021/nn3044066
https://doi.org/10.1021/nn3044066
Autor:
Young Shik Shin, Yapeng Su, Jungwoo Kim, Min Xue, Wilson X. Mai, David Nathanson, James R. Heath, Wei Wei
Publikováno v:
Journal of the American Chemical Society, vol 137, iss 12
We describe chemical approaches for integrated metabolic and proteomic assays from single cells. Quantitative assays for intracellular metabolites, including glucose uptake and three other species, are designed as surface-competitive binding assays w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4155a793a5fdc509fee2cdba7b1dccc
https://escholarship.org/uc/item/93b3x8r9
https://escholarship.org/uc/item/93b3x8r9
Autor:
Wilson X. Mai, Huan Meng
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro. 5(1)
Efficient and safe drug delivery has always been a challenge in medicine. The use of nanotechnology, such as the development of nano drug delivery systems (DDS), has received great attention with high enthusiasm owing to the potential that nanocarrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db4928b7eee8f01cff8da4edd6f4889
https://pubmed.ncbi.nlm.nih.gov/23042147
https://pubmed.ncbi.nlm.nih.gov/23042147