Zobrazeno 1 - 10
of 388
pro vyhledávání: '"Wilson S Colucci"'
Autor:
Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Aly Elezaby, Xiaoyan Yin, Deborah A Siwik, Francesca Seta, Catherine E Costello, Richard A Cohen, Reiko Matsui, Wilson S Colucci, Mark E McComb, Markus M Bachschmid
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144025 (2015)
Reactive protein cysteine thiolates are instrumental in redox regulation. Oxidants, such as hydrogen peroxide (H2O2), react with thiolates to form oxidative post-translational modifications, enabling physiological redox signaling. Cardiac disease and
Externí odkaz:
https://doaj.org/article/17226e23b1354d9a9df939a220b367f6
Autor:
Dominique Croteau, Tomas Baka, Sara Young, Huamei He, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, David R. Pimentel, James A. Balschi, Wilson S. Colucci, Ivan Luptak
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114310- (2023)
Background: Elevated myocardial intracellular sodium ([Na+]i) was shown to decrease mitochondrial calcium ([Ca2+]MITO) via mitochondrial sodium/calcium exchanger (NCXMITO), resulting in decreased mitochondrial ATP synthesis. The sodium-glucose co-tra
Externí odkaz:
https://doaj.org/article/ddbf2c50d47847a383f78995232ae6e7
Autor:
Dominique Croteau, Ivan Luptak, Jordan M. Chambers, Ion Hobai, Marcello Panagia, David R. Pimentel, Deborah A. Siwik, Fuzhong Qin, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz:
https://doaj.org/article/cb89ff2bb7ca44b79b60b9cd0761c0c1
Autor:
Deepa M. Gopal, Nir Ayalon, Yi‐Chih Wang, Deborah Siwik, Aaron Sverdlov, Courtney Donohue, Alejandro Perez, Jill Downing, Caroline Apovian, Vanessa Silva, Marcello Panagia, Vijaya Kolachalama, Jennifer E. Ho, Chang‐seng Liang, Noyan Gokce, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 7 (2019)
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease (MHD) in young obese patients would help identify high‐risk individuals for heart failure prevention s
Externí odkaz:
https://doaj.org/article/67aace46baab412d89d4639149c23c25
Autor:
Xiaoyong Tong, Marcello Panagia, Fuzhong Qin, Deborah A. Siwik, Jena B Goodman, Dominique Croteau, David R. Pimentel, Richard A. Cohen, Ion A. Hobai, Ivan Luptak, Markus Bachschmid, Wilson S. Colucci, Robert J. Morgan, Jordan M. Chambers
Publikováno v:
Circulation. 142:2459-2469
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochon
Autor:
Edward J. Miller, Timothy Calamaras, Aly Elezaby, Aaron Sverdlov, Fuzhong Qin, Ivan Luptak, Ke Wang, Xinxin Sun, Andrea Vijay, Dominique Croteau, Markus Bachschmid, Richard A. Cohen, Kenneth Walsh, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMyocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism
Externí odkaz:
https://doaj.org/article/5e3d41148a354572bb88926c7948ce0c
Autor:
Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz:
https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
Autor:
Tomas Baka, Dominique Croteau, Jordan Chambers, Huamei He, James Balschi, Fuzhong Qin, Wilson S Colucci, David Pimentel, Ivan Luptak
Publikováno v:
Circulation. 144
Background: It is well established that hearts with hypertrophic cardiomyopathy (HCM) are energy starved as reflected by a decreased phosphocreatine to ATP ratio that corresponds to increased ADP and decreased free energy of ATP hydrolysis (ΔG ~ATP
Autor:
Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Autor:
Wilson S. Colucci, Aaron L. Sverdlov, Donia Macartney-Coxson, Doan T.M. Ngo, Shakun Karki, Melissa G. Farb, Richard S. Stubbs, Noyan Gokce, Donald T. Hess, Brian Carmine
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 316:E168-E177
Obesity, particularly visceral adiposity, has been linked to mitochondrial dysfunction and increased oxidative stress, which have been suggested as mechanisms of insulin resistance. The mechanism(s) behind this remains incompletely understood. In thi