Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Wilson Phung"'
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment,
Externí odkaz:
https://doaj.org/article/1f51a60ae7254824a781e70ff1592428
Autor:
Elizabeth Sara Hecht, Shrenik Mehta, Aaron T. Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W. Henry Benner, Devin Tesar, Robert F. Kelley, Wendy Sandoval, Alavattam Sreedhara
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to refining do
Externí odkaz:
https://doaj.org/article/d0847215cccc4d5da45d73cb8db4ce8f
Autor:
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular
Externí odkaz:
https://doaj.org/article/b949b998bea04b119070c87d6eced201
Autor:
Kamal Kishore Joshi, Wilson Phung, Guanghui Han, Yiyuan Yin, Ingrid Kim, Wendy Sandoval, Paul J. Carter
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1254-1265 (2019)
Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by
Externí odkaz:
https://doaj.org/article/0b0701cfc3784dc08be1e7b2752abc7e
Autor:
Bingchuan Wei, Xuan Gao, Lance Cadang, Saeed Izadi, Peilu Liu, Hui-Min Zhang, Elizabeth Hecht, Jeongsup Shim, Gordon Magill, Juan Rincon Pabon, Lu Dai, Wilson Phung, Elaine Lin, Christopher Wang, Kevin Whang, Sean Sanchez, Jose Oropeza Jr, Julien Camperi, Jennifer Zhang, Wendy Sandoval, Yonghua Taylor Zhang, Guoying Jiang
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation betwee
Externí odkaz:
https://doaj.org/article/bdd3b615610e438ebfe86ec19cb0df05
Autor:
Wilson Phung, Guanghui Han, Stéphanie G.I. Polderdijk, Michael Dillon, Whitney Shatz, Peter Liu, Bingchuan Wei, Pawankumar Suresh, David Fischer, Christoph Spiess, Aaron Bailey, Paul J. Carter, Jennie R. Lill, Wendy Sandoval
Publikováno v:
Data in Brief, Vol 30, Iss , Pp 105435- (2020)
The data supplied in this work are related to the research article entitled “Characterization of Bispecific and Mispaired IgGs by Native Charge-Variant Mass Spectrometry” (Phung et al., 2019). This data article describes a powerful analytical pla
Externí odkaz:
https://doaj.org/article/3d70c2e23d894d29be80278d6eb3b339
Autor:
Yvonne Chen, Maciej Paluch, Julie A. Zorn, Sharmila Rajan, Brandon Leonard, Alberto Estevez, John Brady, Henry Chiu, Wilson Phung, Amin Famili, Minhong Yan, Claudio Ciferri, Marissa L. Matsumoto, Greg A. Lazar, Susan Crowell, Phil Hass, Nicholas J. Agard
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. How
Externí odkaz:
https://doaj.org/article/28ad3cfcdaf4459abab263005b66f32a
Autor:
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas Agard, Matthieu Masureel, Joshua Gober, Adel ElSohly, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Glycosylated biotherapeutics are an emerging class of drugs with high molecular heterogeneity, which can affect their safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df06bf053a921f4b232ad59ea02b7183
https://doi.org/10.21203/rs.3.rs-2928767/v1
https://doi.org/10.21203/rs.3.rs-2928767/v1
Recent advances in native mass spectrometry (MS) and denatured intact protein MS have made these techniques essential for biotherapeutic characterization. As MS analysis has increased in throughput and scale, new data analysis workflows are needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a18f7e5fc20a7831fe115e30667d6303
https://doi.org/10.26434/chemrxiv-2023-tbh20
https://doi.org/10.26434/chemrxiv-2023-tbh20
Autor:
Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu
Publikováno v:
Nature, vol 609, iss 7926
The RAS–RAF pathway is one of the most commonly dysregulated in human cancers1–3. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation4 of the kinase RAF remains limited. Recent structures of