Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Wilson Noel S"'
Autor:
Harris, Christopher M. *, Foley, Sage E., Goedken, Eric R., Michalak, Mark, Murdock, Sara, Wilson, Noel S.
Publikováno v:
In SLAS Discovery December 2018 23(10):1040-1050
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280
https://doi.org/10.1021/acs.jmedchem.0c01280
Autor:
Eric R. Goedken, Wilson Noel S, Sage E. Foley, Christopher M. Harris, Sara Murdock, Mark Michalak
Publikováno v:
SLAS Discovery. 23:1040-1050
In vitro analysis of covalent inhibitors requires special consideration, due to the time-dependent and typically irreversible nature of their target interaction. While many analyses are reported for the characterization of a final candidate, it is le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072debe51808c8101f1bca96e6869e63
https://doi.org/10.1177/2472555218787445
https://doi.org/10.1177/2472555218787445
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Julia Gavrilyuk, Wilson Noel S, Jonathan J Hulce, Sami Osman, Maria A. Argiriadi, Anil Vasudevan, Aleksandra Baranczak, Michael Friedman, Adrian D. Hobson
Covalent modulation of protein function can have multiple utilities including therapeutics, and probes to interrogate biology. While this field is still viewed with scepticism due to the potential for (idiosyncratic) toxicities, significant strides h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7503c7128199dd6b6b36ccad1165161
https://doi.org/10.1016/bs.pmch.2018.12.002
https://doi.org/10.1016/bs.pmch.2018.12.002
Autor:
Wilson Noel S, Gagandeep Somal, Michael Z. Hoemann, Don Konopacki, Maria A. Argiriadi, Anil Vasudevan, David B. Duignan, Bruce Clapham, David Banach, Phil B. Cox, Andrew Burchat, David J. Calderwood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5562-5567
A series of furano[3,2-d]pyrimidine Syk inhibitors were synthesized and optimized for their enzyme potency and selectivity versus other kinases. In addition, ADME properties were assessed and compounds were prepared with optimized profiles for in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9516261e3731d757da98b64f609b1a0f
https://doi.org/10.1016/j.bmcl.2016.09.077
https://doi.org/10.1016/j.bmcl.2016.09.077
Autor:
Harris, Christopher M., Foley, Sage E., Goedken, Eric R., Michalak, Mark, Murdock, Sara, Wilson, Noel S.
Supplemental material, Supplemental_Material_Covalent_BTK_by_Harris,_et_al for Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase by Christopher M. Harris, Sage E. Foley, Eric R. Goedken, Mark Michalak, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0677e8147d1c6aa2fe479b01f4427d66
Autor:
Dietrich, Justin D., Longenecker, Kenton L., Wilson, Noel S., Goess, Christian, Panchal, Sanjay C., Swann, Steven L., Petros, Andrew M., Hobson, Adrian D., Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M., Cox, Philip B., Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L., Duignan, David B., Gomtsyan, Arthur, Jung, Paul, Krueger, A. Chris
Publikováno v:
Journal of Medicinal Chemistry; 1/14/2021, Vol. 64 Issue 1, p417-429, 13p
Publikováno v:
In Tetrahedron Letters 22 August 2012 53(34):4498-4501