Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Wilson Matthew Allan"'
Autor:
Michael P. Winters, Renee L. DesJarlais, Mark Bobko, John P. Wolak, Ho Yin Lo, Steven S. Pullen, Deborah D. Jeanfavre, Hnin Hnin Khine, Rosemarie H. Sallati, Ernest L. Raymond, Mohammed A. Kashem, Lei Qiao, Gregory P. Roth, Declan Ryan, Joseph R. Woska, Kevin J. Moriarty, Darius Robinson, Hidenori Takahashi, B. Tomczuk, Wilson Matthew Allan, Ronald L. Magolda, Peter Allen Nemoto, Andre White, Brian Nicholas Cook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5545-5549
A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure-activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77216c0a135ce0c04945949b146cd09c
https://doi.org/10.1016/j.bmcl.2008.09.015
https://doi.org/10.1016/j.bmcl.2008.09.015
Publikováno v:
Tetrahedron Letters. 50:4807-4809
A simplified approach to the uncatalyzed Paal-Knorr condensation using microwave irradiation in water is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ef57148f41ac171ac2ac81b37c7419
https://doi.org/10.1016/j.tetlet.2009.06.079
https://doi.org/10.1016/j.tetlet.2009.06.079
Autor:
Jeffrey Curtis Kern, Peter V.N. Bodine, Shoichi Fukayama, Gregory S. Welmaker, Girija Krishnamurthy, Thomas Joseph Commons, Lisa Nogle, William Jay Moore, Ramesh A. Bhat, Keith Pitts, Eugene John Trybulski, Barb Stauffer, Wilson Matthew Allan, Igor Goljer, Ronald L. Magolda
Publikováno v:
Journal of medicinal chemistry. 52(1)
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0856734d48b2f78ae9483671c5b4443c
https://pubmed.ncbi.nlm.nih.gov/19072540
https://pubmed.ncbi.nlm.nih.gov/19072540
Autor:
Jeffrey Curtis Kern, Shoichi Fukayama, Gregory S. Welmaker, Mengxiao Shi, Thomas Joseph Commons, Richard Page Woodworth, Barry S. Komm, Robert A. Moran, Girija Krishnamurthy, Wilson Matthew Allan, Ramesh A. Bhat, Annamarie Mangine, Peter V.N. Bodine, Laura M. Seestaller-Wehr, William Jay Moore, Keith Pitts, Eugene John Trybulski, Barbara Stauffer, Julia Billiard, Ariamala Gopalsamy, Helga Ponce-de-Leon
Publikováno v:
Bone. 44(6)
Canonical Wnt signaling has been demonstrated to increase bone formation, and Wnt pathway components are being pursued as potential drug targets for osteoporosis and other metabolic bone diseases. Deletion of the Wnt antagonist secreted frizzled-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca48c16a82a8b27c92ce162b2bb041c3
https://pubmed.ncbi.nlm.nih.gov/19254787
https://pubmed.ncbi.nlm.nih.gov/19254787
Autor:
John P. Wolak, Brian Nicholas Cook, Andre White, Ronald L. Magolda, Declan Ryan, Deborah D. Jeanfavre, Rosemarie H. Sallati, Gregory Roth, Lei Qiao, Darius Robinson, Wilson Matthew Allan, Ernest L. Raymond, Peter Allen Nemoto, Steven S. Pullen, Joseph R. Woska, Ho Yin Lo, Bruce E. Tomczuk, Hnin Hnin Khine, Mark A. Bobko, Michael P. Winters, Kevin J. Moriarty, Renee L. DesJarlais, Mohammed A. Kashem, Hidenori Takahashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5b96b24d26df2b34f888a499446a2b
https://doi.org/10.1016/j.bmcl.2008.09.114
https://doi.org/10.1016/j.bmcl.2008.09.114