Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Wilson M, Connolly"'
Autor:
David Jetton, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Rebecca Batorsky, Joan Mecsas, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114641- (2024)
Summary: Caspase-8-dependent pyroptosis has been shown to mediate host protection from Yersinia infection. For this mode of cell death, the kinase activity of receptor-interacting protein kinase 1 (RIPK1) is required, but the autophosphorylation site
Externí odkaz:
https://doaj.org/article/8f76fc38478046edb57e8621e9f53391
Autor:
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Alexander Poltorak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
Externí odkaz:
https://doaj.org/article/c23eacb750254746b5eeb2cdfdaf0689
Autor:
Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Summary: Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activa
Externí odkaz:
https://doaj.org/article/b14db846e8cc4f8c8f65d98ff6c63481
Autor:
Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova, Edouard Vannier, Xudong Li, Amanda J. Martinot, Rebecca Batorsky, Alexander Poltorak
Publikováno v:
Sci Immunol
TNF mediates a variety of biological processes including cellular proliferation, inflammatory responses, and cell death and is therefore associated with numerous pathologies including autoinflammatory diseases and septic shock. The inflammatory and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9307eb3fde09c39761121d8bf642ad
https://doi.org/10.1126/sciimmunol.add0665
https://doi.org/10.1126/sciimmunol.add0665
Autor:
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Irina Smirnova, Alexei Degterev, Siddharth Balachandran, Alexander Poltorak
Publikováno v:
Proceedings of the National Academy of Sciences. 119
ZBP1 is widely recognized as a mediator of cell death for its role in initiating necroptotic, apoptotic, and pyroptotic cell death pathways in response to diverse pathogenic infection. Herein, we characterize an unanticipated role for ZBP1 in promoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56658ecc0d309b1806e4791bec5acaf2
https://doi.org/10.1073/pnas.2113872119
https://doi.org/10.1073/pnas.2113872119
Autor:
Alexander Poltorak, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Keith P. Eidell, Irina Smirnova
Publikováno v:
Science. 367:1379-1384
Macrophages cFLIP out Pathogens have evolved to survive within hosts in part by interfering with host signaling cascades. Yersinia bacteria use the effector protein YopJ to thwart MAP kinase signaling downstream of Toll-like receptor activation. In r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa130518942ad7f7b4e9bcf5841171db
https://doi.org/10.1126/science.aay3878
https://doi.org/10.1126/science.aay3878
Autor:
Vladimir Ilyukha, Alexei Degterev, Wilson M. Connolly, Hayley I. Muendlein, Beiyun C. Liu, Nahum Sonenberg, Jodie R. Pietruska, Alexander Poltorak, Stephen A Schworer, Amy Y. Tang, Irina Smirnova, Joseph Sarhan, Soroush Tahmasebi
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Cell reports
Cell reports
SUMMARY Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4a1250365ebdbe7fbf10d5c8e26b77
http://www.sciencedirect.com/science/article/pii/S2211124719317309
http://www.sciencedirect.com/science/article/pii/S2211124719317309
Autor:
Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Wilson M. Connolly, Zoie Magri, Alexander Poltorak, Irina Smirnova, Hayley I. Muendlein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly regulated transition from TNFR1-associated pro-inflammatory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab995cc94970d5d5fc9a073c627ec3a
https://doi.org/10.1038/s41467-020-20357-z
https://doi.org/10.1038/s41467-020-20357-z
Autor:
Hayley I, Muendlein, David, Jetton, Wilson M, Connolly, Keith P, Eidell, Zoie, Magri, Irina, Smirnova, Alexander, Poltorak
Publikováno v:
Science
Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11–mediated gasdermin D pore formation. In vivo, responses to lipopolysa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d89b3d3f6a3bcd12bce2e0efed4c2dd1
https://pubmed.ncbi.nlm.nih.gov/32193329
https://pubmed.ncbi.nlm.nih.gov/32193329