Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Wilson Lek Wen, Tan"'
Autor:
Weili Xu, Gianni Monaco, Eleanor Huijin Wong, Wilson Lek Wen Tan, Hassen Kared, Yannick Simoni, Shu Wen Tan, Wilson Zhi Yong How, Crystal Tze Ying Tan, Bernett Teck Kwong Lee, Daniel Carbajo, Srinivasan K.G., Ivy Chay Huang Low, Esther Wing Hei Mok, Shihui Foo, Josephine Lum, Hong Liang Tey, Wee Ping Tan, Michael Poidinger, Evan Newell, Tze Pin Ng, Roger Foo, Arne N. Akbar, Tamas Fülöp, Anis Larbi
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 44-58 (2019)
Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T
Externí odkaz:
https://doaj.org/article/1de8ee1204604eb2a6fbd69c78a8cfae
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-4 (2018)
Abstract The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expr
Externí odkaz:
https://doaj.org/article/833f1df0df2b40b89d72a69510aa79ec
Autor:
Wilson Lek Wen Tan, Wei Qiang Seow, Angela Zhang, Siyeon Rhee, Wing H. Wong, William J. Greenleaf, Joseph C. Wu
Publikováno v:
Nature Cardiovascular Research. 2:20-34
Publikováno v:
Nature Reviews Cardiology. 19:7-25
The Human Genome Project marked a major milestone in the scientific community as it unravelled the ~3 billion bases that are central to crucial aspects of human life. Despite this achievement, it only scratched the surface of understanding how each n
Publikováno v:
Heart failure clinics. 18(3)
The development of human-induced pluripotent stem cell-derived cardiac cell types has created a new paradigm in assessing drug-induced cardiotoxicity. Advances in genomics and epigenomics have also implicated several genomic loci and biological pathw
Autor:
Peng Zhang, Yun Jiang, Xiujian Yu, Qiang Wu, Jinxi Wang, Jiliang Tan, Wilson Lek Wen Tan, Qiang Li, Shenyan Liu, Zenia Tiang, Roger Foo, Huang-Tian Yang, Zhongyan Chen, Shihui Wang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
Human pluripotent stem cells (hPSCs)-derived cardiovascular progenitor cells (CVPCs) are a promising source for myocardial repair, while the mechanisms remain largely unknown. Extracellular vesicles (EVs) are known to mediate cell–cell communicatio
Autor:
Chukwuemeka George Anene-Nzelu, Michael Kinter, Hesham A. Sadek, Jainy J. Savla, Salim Abdisalaam, Luke I. Szweda, Abdallah Elnwasany, Roger Foo, Ursa Bezan Petric, Ana Helena Macedo Pereira, Ivan Menendez-Montes, Mohammed Kanchwala, Chalermchai Khemtong, Yuji Nakada, Wilson Lek Wen Tan, Shujuan Li, Craig R. Malloy, Mahmoud S. Ahmed, Kaitlyn M. Eckert, Ngoc Uyen Nhi Nguyen, A. Dean Sherry, Emily L Ensley, Aroumougame Asaithamby, Gaurav Sharma, Gonçalo Vale, Chao Xing, Linzhang Huang, Matthew A. Mitsche, Nicholas T. Lam, Philip W. Shaul, Alisson C. Cardoso, Joseph A. Hill, Waleed M. Elhelaly, Jeffrey G. McDonald
Publikováno v:
Nature Metabolism. 2:167-178
The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the first week of life, which coincides with a postnatal shift from anaerobic glycolysis to mitochondri
Autor:
Dongchao Lu, Shambhabi Chatterjee, Ke Xiao, Isabelle Riedel, Cheng-Kai Huang, Alessia Costa, Sarah Cushman, Dimyana Neufeldt, Laura Rode, Arne Schmidt, Malte Juchem, Julia Leonardy, Gwen Büchler, Jonas Blume, Olivia-Luise Gern, Ulrich Kalinke, Wilson Lek Wen Tan, Roger Foo, Aryan Vink, Linda W van Laake, Peter van der Meer, Christian Bär, Thomas Thum
Publikováno v:
European Heart Journal, 43(42), 4496-4511. Oxford University Press
Aims Cardiotoxicity leading to heart failure (HF) is a growing problem in many cancer survivors. As specific treatment strategies are not available, RNA discovery pipelines were employed and a new and powerful circular RNA (circRNA)-based therapy was
Autor:
Chukwuemeka George Anene-Nzelu, Peter Yiqing Li, Tuan Danh Anh Luu, Shi Ling Ng, Zenia Tiang, Bangfen Pan, Wilson Lek Wen Tan, Matthew Ackers-Johnson, Ching Kit Chen, Yee Phong Lim, Rina Wang Miao Qin, Wee Woon Chua, Lim Xin Yi, Roger Sik-Yin Foo, Yusaku Nakabeppu
Publikováno v:
Oxidative medicine and cellular longevity. 2022
Doxorubicin is an anthracycline widely used for the treatment of various cancers; however, the drug has a common deleterious side effect, namely a dose-dependent cardiotoxicity. Doxorubicin treatment increases the generation of reactive oxygen specie
Autor:
Chuo, Kini Rm, Julien Pompon, Wilson Lek Wen Tan, Avisha Chowdhury, Yeh S, Mariano A. Garcia-Blanco
Mosquito transmission of dengue viruses to humans starts with infection of skin resident cells at the biting site. There is great interest in identifying transmission-enhancing factors in mosquito saliva in order to counteract them. Here we report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cd006931b0aa9e4c641751becd198f6
https://doi.org/10.1101/2021.03.02.433543
https://doi.org/10.1101/2021.03.02.433543