Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

Autor: Kelvin See, Wilson L. W. Tan, Eng How Lim, Zenia Tiang, Li Ting Lee, Peter Y. Q. Li, Tuan D. A. Luu, Matthew Ackers-Johnson, Roger S. Foo

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Adult mammalian cardiomyocytes are predominantly binucleated and unable to divide. Using single nuclear RNA-sequencing of cardiomyocytes from mouse and human failing and non-failing adult hearts, See et al. show that some cardiomyocytes respond to st

Externí odkaz: https://doaj.org/article/1cd271ae581b47ee8f939fe35db91009

Statins improve endothelial function via suppression of epigenetic-driven EndMT.

Autor: Liu C; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA.; These authors contributed equally: Chun Liu, Mengcheng Shen, Wilson L. W. Tan., Shen M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA.; These authors contributed equally: Chun Liu, Mengcheng Shen, Wilson L. W. Tan., Tan WLW; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA.; These authors contributed equally: Chun Liu, Mengcheng Shen, Wilson L. W. Tan., Chen IY; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA.; Medical Service (Cardiology Section), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA., Liu Y; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA., Yu X; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA., Yang H; Department of Biomedical Engineering, University of North Texas, Denton, TX, USA., Zhang A; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA.; Greenstone Biosciences, Palo Alto, CA, USA., Liu Y; Department of Bioengineering, Stanford University, Stanford, CA, USA., Zhao MT; Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Ameen M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA., Zhang M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA., Gross ER; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA., Qi LS; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Sarafan ChEM-H, Standford University, Stanford, CA, USA.; Chan Zuckerberg Biohub-San Francisco, San Francisco, CA, USA., Sayed N; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Division of Vascular Surgery, Department of Surgery, Standford University, Stanford, CA, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine (Division of Cardiology), Stanford University, Stanford, CA, USA.; Greenstone Biosciences, Palo Alto, CA, USA.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 May; Vol. 2 (5), pp. 467-485. Date of Electronic Publication: 2023 May 08.