Výsledky vyhledávání - "Wilson K.W. Luk"

Akademický článek

Molecular assembly and biosynthesis of acetylcholinesterase in brain and muscle: The roles of t-peptide, FHB domain and N-linked glycosylation

Autor: Vicky P. Chen, Wilson K.W. Luk, Wallace K.B. Chan, K. Wing eLeung, Ava J.Y. Guo, Gallant K.L. Chan, Sherry L. Xu, Roy C.Y. Choi, Karl W.K. Tsim

Publikováno v: Frontiers in Molecular Neuroscience, Vol 4 (2011)

Acetylcholinesterase (AChE) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. The functional localization and oligomerization of AChE T variant are depending primarily on the association of their anchori

Externí odkaz: https://doaj.org/article/5314fdbd7ea04d30a3351726db1f49a4

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Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast

Autor: Ping Yao, Etta Y. L. Liu, Miranda L. Xu, Karl Wah Keung Tsim, Tina T. X. Dong, Wilson K.W. Luk, Kevin Qiyun Wu, Cathy W. C. Bi

Publikováno v: Journal of Neurochemistry. 146:390-402

Acetylcholinesterase (AChE; EC 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. In mammalian erythrocyte, AChE exists as a dimer (G2 ) and is proposed to play role in erythropoiesis. To reveal the regulation of AChE during differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9ac6dbef57a2d9723ba284a1be2e3a
https://doi.org/10.1111/jnc.14448

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Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor

Autor: Karl Wah Keung Tsim, Qi Y. Wu, Miranda L. Xu, Ying J. Xia, Tina T. X. Dong, Wilson K.W. Luk, Etta Y. L. Liu, Xiang P. Kong

Publikováno v: Chemico-biological interactions. 308

Acetylcholinesterase (AChE) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of AChE, i.e. AChER, AChEH and AChET, deriving from single gene. AChEH exists as a glycophosphatidylinositol (GPI)-linked dimer (G2), present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11a7861923a0ad5e235a16c41cab403
https://pubmed.ncbi.nlm.nih.gov/31170385

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Reduced Expression of P2Y2 Receptor and Acetylcholinesterase at Neuromuscular Junction of P2Y1 Receptor Knock-out Mice

Autor: Ping Yao, Wilson K.W. Luk, Anthony W.M. Cheng, Lily K. W. Cheng, Cathy W. C. Bi, Miranda L. Xu, Karl Wah Keung Tsim, Shinghung Mak, Kitty K.M. Lau

Publikováno v: Journal of Molecular Neuroscience. 57:446-451

ATP is co-stored and co-released with acetylcholine (ACh) at the pre-synaptic vesicles in vertebrate neuromuscular junction (nmj). Several lines of studies demonstrated that binding of ATP to its corresponding P2Y1 and P2Y2 receptors in the muscle re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef213634a791d6ab46c7c1b97bce1fa2
https://doi.org/10.1007/s12031-015-0591-9

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Acetylcholinesterase Protein Level Is Preserved in the Alzheimer's Brain

Autor: Karl Wah Keung Tsim, Maria-Letizia Campanari, María-Salud García-Ayllón, Lidia Blazquez-Llorca, Wilson K.W. Luk, Javier Sáez-Valero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Acetylcholinesterase (AChE) is a key enzyme in the cholinergic nervous system and is one of the most studied proteins in the field of Alzheimer's disease (AD). Moreover, alternative functions of AChE unrelated with the hydrolysis of acetylcholine are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb0599872b1ae3ee5864ac798cebe0a
https://doi.org/10.1007/s12031-013-0183-5

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Characterizations of Cholinesterases in Golden Apple Snail (Pomacea canaliculata)

Autor: Sun Yanjie, Wilson K.W. Luk, Heidi Qunhui Xie, Yuzhong Zheng, Tina T. X. Dong, Guangcai Zha, Roy Chi Yan Choi, Karl Wah Keung Tsim, Vicky Ping Chen, Xianghui Zou

Publikováno v: Journal of Molecular Neuroscience. 53:424-428

Cholinesterases (ChEs) have been identified in vertebrates and invertebrates. Inhibition of ChE activity in invertebrates, such as bivalve molluscs, has been used to evaluate the exposure of organophosphates, carbamate pesticides, and heavy metals in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df55045c093d7633dcfa7b28096c7a
https://doi.org/10.1007/s12031-013-0168-4

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Characterization of acetylcholinesterase in Hong Kong oyster (Crassostrea hongkongensis) from South China Sea

Autor: Roy Chi Yan Choi, Guangcai Zha, Wilson K.W. Luk, Xianghui Zou, Vicky Ping Chen, Karl Wah Keung Tsim

Publikováno v: Chemico-Biological Interactions. 203:277-281

Acetylcholinesterase (AChE) activity has been used to evaluate the exposure of mollusk bivalves to organophosphates, carbamate pesticides, and heavy metals. Crassostrea hongkongensis is a Hong Kong endemic oyster, and has a high commercial value alon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7563448223eada3520374483bc238e5f
https://doi.org/10.1016/j.cbi.2012.09.005

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N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting

Autor: Roy Chi Yan Choi, Wilson K.W. Luk, Karl Wah Keung Tsim, Vicky Ping Chen

Publikováno v: FEBS Journal. 279:3229-3239

Acetylcholinesterase (AChE) is well-known for its cholinergic functions in the nervous system; however, this enzyme is also found in other tissues where its function is still not understood. AChE is synthesized through alternative splicing as splicin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6562c4ad6021387d8effcaca7cfa2c69
https://doi.org/10.1111/j.1742-4658.2012.08708.x

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N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase

Autor: Roy Chi Yan Choi, Karl Wah Keung Tsim, Wilson K.W. Luk, Vicky Ping Chen, Wallace K.B. Chan

Publikováno v: Neuroscience Letters. 523:71-75

Acetylcholinesterase (AChE) is organized into globular tetramers (G4) by a structural protein called p roline- ri ch m embrane a nchor (PRiMA), anchoring it into the cell membrane of neurons in the brain. The assembly of AChE tetramers with PRiMA req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256eb497172a9896dba400d928fc5ed0
https://doi.org/10.1016/j.neulet.2012.06.045

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Quantification of the transcripts encoding different forms of AChE in various cell types: Real-time PCR coupled with standards in revealing the copy number

Autor: Yuen H. Liu, Wilson K.W. Luk, Maria-Letizia Campanari, Cathy W. C. Bi, Roy Chi Yan Choi, Karl Wah Keung Tsim, Kei M. Lau, Javier Sáez-Valero, Li Xu, Miranda L. Xu

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Acetylcholinesterase (AChE) is encoded by a single gene, and the alternative splicing at the 3′ end produces different isoforms, including tailed (AChET), read-through (AChER), and hydrophobic (AChEH). Different forms of this enzyme exist in differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b11e0946514789183088ce920dddbfc
http://hdl.handle.net/10261/123011

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