Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Wilson K Clements"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 12, p e1011102 (2023)
Acute lymphoblastic leukemia/lymphoma (ALL) is the most common pediatric cancer and is a malignancy of T or B lineage lymphoblasts. Dysregulation of intracellular Ca2+ levels has been observed in patients with ALL, leading to improper activation of d
Externí odkaz:
https://doaj.org/article/a8847c528dd041ef9bf13daa3f168aa8
Publikováno v:
Oncotarget
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128f4572c1a1283cd28cb2e13cc4c558
http://europepmc.org/articles/PMC7321698
http://europepmc.org/articles/PMC7321698
Autor:
David B. Finkelstein, Karen Vrijens, Taosheng Chen, Jose Grenet, Jaeki Min, Wilson K. Clements, R. Kiplin Guy, Anang A. Shelat, Wenwei Lin, Martine F. Roussel, Dana Farmer, Jamie R. Genthe
Publikováno v:
ACS Chemical Biology. 12:2436-2447
Here we describe three new small-molecule activators of BMP signaling found by high throughput screening of a library of ~600,000 small molecules. Using a cell-based luciferase assay in the BMP4-responsive human cervical carcinoma clonal cell line, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed17e46933d04c11e1617f89be76eae
https://doi.org/10.1021/acschembio.7b00527
https://doi.org/10.1021/acschembio.7b00527
Autor:
Jamie R. Genthe, Wilson K. Clements
Publikováno v:
Development. 145
Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow transplants, but finding immune-compatible donors limits treatment availability and efficacy. Recapitulation of endogenous specification during development is a promising ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cbaba6036b31656fd24e12e99065d2
https://doi.org/10.1242/dev.173344
https://doi.org/10.1242/dev.173344
Autor:
Natasha Del Cid, Christian Mosimann, David L. Stachura, Fabienne E. Poulain, Chih-Wen Ni, Nathan D. Lawson, Martin Distel, Richard I. Dorsky, Raquel Espín-Palazón, Isao Kobayashi, Bart Weijts, Emerald Butko, Claire Pouget, David Traver, Kevin Ng, Adam D. McPherson, Wilson K. Clements
Publikováno v:
Development (Cambridge England)
The adult blood system is established by hematopoietic stem cells (HSCs), which arise during development from an endothelial-to-hematopoietic transition of cells comprising the floor of the dorsal aorta. Expression of aortic runx1 has served as an ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5021584c7c2aff686a34ebaa18879d45
https://doi.org/10.1242/dev.119180
https://doi.org/10.1242/dev.119180
Autor:
Jamie R. Genthe, Wilson K. Clements
Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow transplants, but finding immune-compatible donors limits treatment availability and efficacy. Recapitulation of endogenous specification during development is a promising ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfaf78d56b83f30267d92dd402faf49d
https://europepmc.org/articles/PMC5312032/
https://europepmc.org/articles/PMC5312032/
Autor:
David L. Stachura, Lindsey Mork, Calum A. MacRae, David Traver, Martin Distel, Albert D. Kim, J. Gage Crump, Chase H. Melick, Wilson K. Clements, Daniela Panáková
Publikováno v:
The EMBO Journal. 33:2363-2373
Hematopoietic stem cells (HSCs) require multiple molecular inputs for proper specification, including activity of the Notch signaling pathway. A requirement for the Notch1 and dispensability of the Notch2 receptor has been demonstrated in mice, but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3581fc0fff57ff664329dc1f768963
https://doi.org/10.15252/embj.201488784
https://doi.org/10.15252/embj.201488784
Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche
Autor:
Erich W. Damm, Wilson K. Clements
Publikováno v:
Nature cell biology
Haematopoietic stem cells (HSCs) support maintenance of the haematopoietic and immune systems throughout the life of vertebrates, and are the therapeutic component of bone marrow transplants. Understanding native specification of HSCs, to uncover key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274eebeb3b094fff3d20b75eafbea64a
https://pubmed.ncbi.nlm.nih.gov/28394883
https://pubmed.ncbi.nlm.nih.gov/28394883
CONTRIBUTION OF SCLEROTOME TO THE EMBRYONIC HEMATOPOIETIC STEM CELL NICHE AND VASCULAR SMOOTH MUSCLE
Publikováno v:
Experimental Hematology. 76:S71
Hematopoietic stem cells (HSCs) are a self-renewing population that sustains production of blood lineages throughout life. Vertebrate HSCs are first specified in the embryo, arising from hemogenic endothelium in the ventral wall of the dorsal aorta (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ca5d0e9f1017677a7b07cc8a5856a91
https://doi.org/10.1016/j.exphem.2019.06.377
https://doi.org/10.1016/j.exphem.2019.06.377
Autor:
Wilson K. Clements, David Traver
Publikováno v:
Nature Reviews Immunology. 13:336-348
Haematopoietic stem cells (HSCs) are tissue-specific stem cells that replenish all mature blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of transplantation-based therapies for leukaemias and congenital blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95288f9375e71dea9a8c72ada6003ba
https://doi.org/10.1038/nri3443
https://doi.org/10.1038/nri3443