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Akademický článek

Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects

Autor: Shen Z, Gillen M, Miner JN, Bucci G, Wilson DM, Hall JW

Publikováno v: Drug Design, Development and Therapy, Vol Volume 11, Pp 2077-2086 (2017)

Zancong Shen,1 Michael Gillen,2 Jeffrey N Miner,1 Gail Bucci,1 David M Wilson,1 Jesse W Hall1 1Ardea Biosciences, Inc., San Diego, CA, 2AstraZeneca, Gaithersburg, MD, USA Purpose: Verinurad (RDEA3170) is a selective uric acid reabsorption inhibitor i

Externí odkaz: https://doaj.org/article/1e3e8ebc8c2c416ba280648bce2920eb

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Akademický článek

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

Autor: Shen Z, Gillen M, Tieu K, Nguyen M, Harmon E, Wilson DM, Kerr B, Lee CA

Publikováno v: Drug Design, Development and Therapy, Vol Volume 10, Pp 3509-3517 (2016)

Zancong Shen,1 Michael Gillen,2 Kathy Tieu,1 Mai Nguyen,1 Erin Harmon,1 David M Wilson,1 Bradley Kerr,1 Caroline A Lee1 1Ardea Biosciences, Inc., San Diego, CA, 2AstraZeneca LP, Gaithersburg, MD, USA Introduction: Lesinurad is a selective uric acid r

Externí odkaz: https://doaj.org/article/956896beeaa84ecd8a54888ca1c29996

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Different white people: communists, unionists and Aboriginal Rights 1946-1972

Autor: Wilson, DM

This thesis is an examination of left-wing activist contributions to the Aboriginal rights movement in Australia, with focus upon three important campaigns: > Pilbara pastoral walk-offs in Western Australia 1946 ‚Äö- 1949 > Protests about weapons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d311deb7fd8c5ac82d8f72832a3e38

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Dicarboxylic acids as pH sensors for hyperpolarized C-13 magnetic resonance spectroscopic imaging

Autor: Korenchan, DE, Taglang, C, von Morze, C, Blecha, JE, Gordon, JW, Sriram, R, Larson, PEZ, Vigneron, DB, VanBrocklin, HF, Kurhanewicz, J, Wilson, DM, Flavell, RR

Publikováno v: Korenchan, DE; Taglang, C; von Morze, C; Blecha, JE; Gordon, JW; Sriram, R; et al.(2017). Dicarboxylic acids as pH sensors for hyperpolarized C-13 magnetic resonance spectroscopic imaging. ANALYST, 142(9), 1429-1433. doi: 10.1039/c7an00076f. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1hc2h13n

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::815b5935fb32c3d2832f3fdd7fa326bf
http://www.escholarship.org/uc/item/1hc2h13n

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Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging

Autor: Korenchan, DE, Flavell, RR, Baligand, C, Sriram, R, Neumann, K, Sukumar, S, VanBrocklin, H, Vigneron, DB, Wilson, DM, Kurhanewicz, J

Publikováno v: Chemical communications (Cambridge, England), vol 52, iss 14

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2c8810ee7b866808536d12b7ad8e9ba5
https://escholarship.org/uc/item/5wn5j7g2

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Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins

Autor: Wilson, David, Poletto, M, Lirussi, L, Wilson, DM, Tell, G

Publikováno v: Wilson, David; Poletto, M; Lirussi, L; Wilson, DM; & Tell, G. (2014). Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/07s4j2nb

Nucleophosmin (NPM1) is a multifunctional protein that controls cell growth and genome stability via a mechanism that involves nucleolar-cytoplasmic shuttling. It is clear that NPM1 also contributes to the DNA damage response, yet its exact function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c57a567d4b8a5e19a84ad09d86c725d6
http://www.escholarship.org/uc/item/07s4j2nb

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Human Apurinic/Apyrimidinic Endonuclease 1

Autor: Wilson Dm rd, Li M

Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1) was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding activity of certain transcription factors. We review herein topics related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a0abebb4e4339c3579aa3bec4af7fe
https://europepmc.org/articles/PMC3901322/

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A cross-sectional study of osteocalcin and body fat measures among obese adolescents

Autor: Gitelman, Stephen, Lenders, CM, Lee, PDK, Feldman, HA, Wilson, DM, Abrams, SH, Gitelman, SE, Klish, WJ, Wertz, MS, Taylor, GA, Alongi, RT

Publikováno v: Gitelman, Stephen; Lenders, CM; Lee, PDK; Feldman, HA; Wilson, DM; Abrams, SH; et al.(2013). A cross-sectional study of osteocalcin and body fat measures among obese adolescents. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3hh8w71s

Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures. Objective: To examine the relationships of OCN to body fat measures and whether they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::42913692850fb856a5df245b6f0426f4
http://www.escholarship.org/uc/item/3hh8w71s

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Functional assessment of population and tumor-associated APE1 protein variants

Autor: Wilson, David, Illuzzi, JL, Harris, NA, Manvilla, BA, Kim, D, Li, M, Drohat, AC, Wilson, DM

Publikováno v: Wilson, David; Illuzzi, JL; Harris, NA; Manvilla, BA; Kim, D; Li, M; et al.(2013). Functional assessment of population and tumor-associated APE1 protein variants.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6sb591fx

Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3'-5' exonuclease and 3'-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::251da3e9c4f8e0914e668503ec68e731
http://www.escholarship.org/uc/item/6sb591fx

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Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry

Autor: Wilson, David, Kirkali, G, Jaruga, P, Reddy, PT, Tona, A, Nelson, BC, Li, M, Wilson, DM, Dizdaroglu, M

Publikováno v: Wilson, David; Kirkali, G; Jaruga, P; Reddy, PT; Tona, A; Nelson, BC; et al.(2013). Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4zp4k6q3

Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease etiology or therapeutic response prediction. Thus, the accurate determination of DNA repair protein expression and gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::af0c638ac4e9da48a9d6c67a74f6d8d2
http://www.escholarship.org/uc/item/4zp4k6q3

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