Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Wilson C.W. Chan"'
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101698- (2023)
Hypertrophic chondrocytes are found at unique locations at the junction of skeletal tissues, cartilage growth plate, articular cartilage, enthesis and intervertebral discs. Their role in the skeleton is best understood in the process of endochondral
Externí odkaz:
https://doaj.org/article/9f8be16727ae46f5a157dcf596cc5c54
Autor:
Mateusz Kudelko, Peikai Chen, Vivian Tam, Ying Zhang, Oi-Yin Kong, Rakesh Sharma, Tiffany Y.K. Au, Michael Kai-Tsun To, Kathryn S.E. Cheah, Wilson C.W. Chan, Danny Chan
Publikováno v:
Matrix Biology Plus, Vol 12, Iss , Pp 100082- (2021)
Mice are commonly used to study intervertebral disc (IVD) biology and related diseases such as IVD degeneration. Discs from both the lumbar and tail regions are used. However, little is known about compartmental characteristics in the different regio
Externí odkaz:
https://doaj.org/article/0003be98ec494fadac5ad800c0b54986
Autor:
Jia-Chi Yeo, Danny Chan, Sigmar Stricker, Vivian C. W. Ng, Wilson C.W. Chan, Chen Feng, Lam Yan, Stefan Mundlos, Manuel Koch, Kathryn S.E. Cheah, Huck-Hui Ng, Xue Wang, Ben Niu, Peikai Chen
Publikováno v:
Stem Cell Reports
Summary The synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149556f7bcc9ae05794e96b9f22e681e
https://doi.org/10.1016/j.stemcr.2019.08.006
https://doi.org/10.1016/j.stemcr.2019.08.006
Autor:
Srish S. Chenna, Itzel Paola Melgoza, Cheryle A. Séguin, Angela K Brice, Wilson C.W. Chan, Takashi Ohnishi, Emanuel J. Novais, Yejia Zhang, Nam Vo, Simon Y. Tang, Makarand V. Risbud, Geoffrey J. Kerr, Vivian W.Y. Tam, Steven Tessier, Victor Y. L. Leung, Daniel W. Chan, Sarthak Mohanty, Ying Zhang, Chao Ming Zhou, Chitra Lekha Dahia
Publikováno v:
JOR Spine, Vol 4, Iss 2, Pp n/a-n/a (2021)
Paediatrics Publications
JOR Spine
Paediatrics Publications
JOR Spine
Mice have been increasingly used as preclinical model to elucidate mechanisms and test therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc (IVD) histological scoring systems have been proposed, but none exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12474794d767d5100ef555b6612820d7
https://doi.org/10.1002/jsp2.1164
https://doi.org/10.1002/jsp2.1164
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5445, p 5445 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Bone is a dynamic tissue constantly responding to environmental changes such as nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone remodeling, a controlled and balanced process between bone-resorbing osteocla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72d6a2e1595af9d990a8a97aa892ad6
https://www.mdpi.com/1422-0067/22/11/5445
https://www.mdpi.com/1422-0067/22/11/5445
Autor:
Mateusz Kudelko, Muhammad Farooq Rai, Linda J. Sandell, Cheng Wang, James M. Cheverud, Danny Chan, Heather A. Lawson, Pak C. Sham, Kathryn S.E. Cheah, Chi Xiong, Wilson C.W. Chan, Ying Zhang, Yan Li, Vivian W.Y. Tam, Yuk Lun Wong
Publikováno v:
Matrix Biology. 70:123-139
Intervertebral disc degeneration (IDD) causes back pain and sciatica, affecting quality of life and resulting in high economic/social burden. The etiology of IDD is not well understood. Along with aging and environmental factors, genetic factors also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5818f5d5d6ede9a8a0cb5e39cce97c
https://doi.org/10.1016/j.matbio.2018.03.024
https://doi.org/10.1016/j.matbio.2018.03.024
Autor:
Peikai Chen, Daniel W. Chan, Michael Kai-Tsun To, Wilson C.W. Chan, Ying Zhang, Tiffany Y. K. Au, Mateusz Kudelko, Kathryn S.E. Cheah, Rakesh Sharma, Oi-Yin Kong, Vivian W.Y. Tam
Publikováno v:
Matrix Biology Plus, Vol 12, Iss, Pp 100082-(2021)
Matrix Biology Plus
Matrix Biology Plus
Highlights • Proteomics of healthy mouse IVDs differentiating compartments and spine levels. • NP cells feature vacuoles with lysosomal, transport and cell–cell communication functions. • Collagen XII, decorin and other ECM proteins contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e1cb68fed5ed94df97bcfa700de032
https://doi.org/10.1016/j.mbplus.2021.100082
https://doi.org/10.1016/j.mbplus.2021.100082
Autor:
Yin Wo Cheng, Kathryn S.E. Cheah, Halina Chik, Danny Chan, Kenneth M.C. Cheung, Kwok Yeung Tsang, Alan Boyde, Zhijia Tan, Raymond P. Boot-Handford, Vivian C. W. Ng, Wilson C.W. Chan
Publikováno v:
Human Molecular Genetics. 26:4572-4587
Bone remodeling is a balanced process between bone synthesis and degradation, maintaining homeostasis and a constant bone mass in adult life. Imbalance will lead to conditions such as osteoporosis or hyperostosis. Osteoblasts build bone, becoming emb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8d561fa1c7df2d37502b2cd2917c30
https://doi.org/10.1093/hmg/ddx339
https://doi.org/10.1093/hmg/ddx339
Autor:
Michael Q. Zhang, Ben Niu, Keith K.H. Leung, Andrew Tai, Daniel W. Chan, Cheng Wang, Wilson C.W. Chan, Kwok Yeung Tsang, Zhijia Tan, Nelson W F Dung, Rebecca L K Lo, Kathryn S.E. Cheah, Nobuyuki Itoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d505689167d7193806cb750da49e1b
https://doi.org/10.7554/elife.37673.039
https://doi.org/10.7554/elife.37673.039
Autor:
Victor Y. L. Leung, Wilson C.W. Chan, Danny Chan, Cheryle A. Séguin, Vivian W.Y. Tam, Daisuke Sakai, Kenneth M.C. Cheung, Kathryn S.E. Cheah, Jake Bedore, Matthew R. McCann
Publikováno v:
Journal of Orthopaedic Research.
A new scoring system based on histo-morphology of mouse intervertebral disc (IVD) was established to assess changes in different mouse models of IVD degeneration and repair. IVDs from mouse strains of different ages, transgenic mice, or models of art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14bef8a1e94dc4a5a6ea10a9ca0daa6
https://doi.org/10.1002/jor.23637
https://doi.org/10.1002/jor.23637