The root causes of pharmacodynamic assay failure

Autor: Ferry-Galow, Katherine V., Makhlouf, Hala R., Wilsker, Deborah F., Lawrence, Scott M., Pfister, Thomas D., Marrero, Allison M., Bigelow, Kristina M., Yutzy, William H., Ji, Jiuping J., Butcher, Donna O., Gouker, Brad A., Kummar, Shivaani, Chen, Alice P., Kinders, Robert J., Parchment, Ralph E., Doroshow, James H.

Publikováno v: In Seminars in Oncology August 2016 43(4):484-491

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ATR inhibition reverses the resistance of homologous recombination deficient MGMT ^low /MMR ^proficient cancer cells to temozolomide.

Autor: El Touny LH; Molecular Pharmacology Laboratory, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA.; Current address: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, NIH, Bethesda, MD, USA., Hose C; Molecular Pharmacology Laboratory, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Connelly J; Molecular Pharmacology Laboratory, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Harris E; Molecular Pharmacology Laboratory, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Monks A; Molecular Pharmacology Laboratory, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Dull AB; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Wilsker DF; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Hollingshead MG; Biological Testing Branch, NCI, Frederick, MD, USA., Gottholm-Ahalt M; Biological Testing Branch, NCI, Frederick, MD, USA., Alcoser SY; Biological Testing Branch, NCI, Frederick, MD, USA., Mullendore ME; In Vivo Evaluation Program, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Parchment RE; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA., Doroshow JH; Division of Cancer Treatment and Diagnosis, NCI, Bethesda, MD, USA.; Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, USA., Teicher BA; Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, USA.; Molecular Pharmacology Branch, Developmental Therapeutics Program, NCI, Rockville, MD, USA., Rapisarda A; Molecular Pharmacology Laboratory, Leidos Biomedical Research Inc., FNLCR, Frederick, MD, USA.

Publikováno v: Oncotarget [Oncotarget] 2021 Oct 12; Vol. 12 (21), pp. 2114-2130. Date of Electronic Publication: 2021 Oct 12 (Print Publication: 2021).