Zobrazeno 1 - 10 of 76 pro vyhledávání: '"Wilsher NE"'
1
Akademický článek
Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Autor: Palmer N; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Agnew C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Benn C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Buffham WJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Castro JN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Chessari G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Clark M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cons BD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Coyle JE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Dawson LA; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hamlett CCF; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hodson C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Holding F; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Johnson CN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Liebeschuetz JW; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Mahajan P; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., McCarthy JM; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Murray CW; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., O'Reilly M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Peakman T; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Price A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Rapti M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Reeks J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Schöpf P; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., St-Denis JD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Valenzano C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wallis NG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Walser R; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Weir H; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Woodhead A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Bento CF; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Tisi D; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11168-11181. Date of Electronic Publication: 2024 Jun 27.
Zobrazit plný text záznamu
2
Akademický článek
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
Autor: Day JEH; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Berdini V; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Castro J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Chessari G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Davies TG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Day PJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., St Denis JD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Fujiwara H; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Fukaya S; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Hamlett CCF; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hearn K; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hiscock SD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Holvey RS; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Ito S; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Kandola N; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Kodama Y; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Liebeschuetz JW; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Martins V; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Matsuo K; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Mortenson PN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Muench S; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Nakatsuru Y; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Ochiiwa H; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Palmer N; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Peakman T; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Price A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Reader M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Rees DC; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Rich SJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Shah A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Shibata Y; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Smyth T; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Twigg DG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wallis NG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Williams G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Woodhead A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Shimamura T; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Johnson CN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4655-4675. Date of Electronic Publication: 2024 Mar 10.
Zobrazit plný text záznamu
3
Akademický článek
CYP1-Activation and Anticancer Properties of Synthetic Methoxylated Resveratrol Analogues.
Autor: Ruparelia KC; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Zeka K; Zayed Centre for Research into Rare Disease in Children, University College London, London WC1E 6BT, UK., Beresford KJM; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Wilsher NE; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Potter GA; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Androutsopoulos VP; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Brucoli F; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Arroo RRJ; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 15; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 15.
Zobrazit plný text záznamu
4
Akademický článek
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.
Autor: Munck JM; Astex Pharmaceuticals, Cambridge, United Kingdom. nicola.wallis@astx.com joanne.munck@astx.com., Berdini V; Astex Pharmaceuticals, Cambridge, United Kingdom., Bevan L; Astex Pharmaceuticals, Cambridge, United Kingdom., Brothwood JL; Astex Pharmaceuticals, Cambridge, United Kingdom., Castro J; Astex Pharmaceuticals, Cambridge, United Kingdom., Courtin A; Astex Pharmaceuticals, Cambridge, United Kingdom., East C; Astex Pharmaceuticals, Cambridge, United Kingdom., Ferraldeschi R; Astex Pharmaceuticals, Cambridge, United Kingdom., Heightman TD; Astex Pharmaceuticals, Cambridge, United Kingdom., Hindley CJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Kucia-Tran J; Astex Pharmaceuticals, Cambridge, United Kingdom., Lyons JF; Astex Pharmaceuticals, Cambridge, United Kingdom., Martins V; Astex Pharmaceuticals, Cambridge, United Kingdom., Muench S; Astex Pharmaceuticals, Cambridge, United Kingdom., Murray CW; Astex Pharmaceuticals, Cambridge, United Kingdom., Norton D; Astex Pharmaceuticals, Cambridge, United Kingdom., O'Reilly M; Astex Pharmaceuticals, Cambridge, United Kingdom., Reader M; Astex Pharmaceuticals, Cambridge, United Kingdom., Rees DC; Astex Pharmaceuticals, Cambridge, United Kingdom., Rich SJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Richardson CJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Shah AD; Astex Pharmaceuticals, Cambridge, United Kingdom., Stanczuk L; Astex Pharmaceuticals, Cambridge, United Kingdom., Thompson NT; Astex Pharmaceuticals, Cambridge, United Kingdom., Wilsher NE; Astex Pharmaceuticals, Cambridge, United Kingdom., Woolford AJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Wallis NG; Astex Pharmaceuticals, Cambridge, United Kingdom. nicola.wallis@astx.com joanne.munck@astx.com.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 1757-1768. Date of Electronic Publication: 2021 Jul 30.
Zobrazit plný text záznamu
5
Akademický článek
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Autor: Heightman TD; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Berdini V; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Bevan L; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Buck IM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Carr MG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Courtin A; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Coyle JE; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Day JEH; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., East C; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Fazal L; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Griffiths-Jones CM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Howard S; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Kucia-Tran J; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Martins V; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Muench S; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Munck JM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Norton D; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., O'Reilly M; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Palmer N; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Pathuri P; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Peakman TM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Reader M; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Rees DC; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Rich SJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Shah A; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Wallis NG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Walton H; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Woolford AJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Cooke M; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Cousin D; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Onions S; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Shannon J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Watts J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Murray CW; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 12286-12303. Date of Electronic Publication: 2021 Aug 13.
Zobrazit plný text záznamu
6
Akademický článek
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Autor: Chessari G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hardcastle IR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Ahn JS; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Anil B; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Anscombe E; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Bawn RH; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Bevan LD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Blackburn TJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Buck I; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cano C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Carbain B; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Castro J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cons B; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cully SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Endicott JA; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Fazal L; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Golding BT; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Griffin RJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Haggerty K; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Hearn K; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hobson S; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Holvey RS; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Howard S; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Jennings CE; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Johnson CN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Lunec J; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Miller DC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Newell DR; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Noble MEM; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Reeks J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Revill CH; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Riedinger C; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., St Denis JD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Tamanini E; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Thomas H; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Thompson NT; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Vinković M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wedge SR; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Williams PA; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Zhang B; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Zhao Y; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 4071-4088. Date of Electronic Publication: 2021 Mar 24.
Zobrazit plný text záznamu
7
Akademický článek
Tabersonine enhances cisplatin sensitivity by modulating Aurora kinase A and suppressing epithelial--mesenchymal transition in triple-negative breast cancer.
Autor: Xi Chen1, Yuanliang Yan1, Yuanhong Liu1, Qiaoli Yi1, Zhijie Xu2,3 xzj1322007@csu.edu.cn
Publikováno v: Pharmaceutical Biology. Dec2024, Vol. 62 Issue 1, p394-403. 10p.
Zobrazit plný text záznamu
8
Akademický článek
The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells.
Autor: Ruparelia KC; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Lodhi S; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Ankrett DN; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Wilsher NE; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Arroo RRJ; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Potter GA; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Beresford KJM; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK. Electronic address: kberesford@dmu.ac.uk.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Jun 01; Vol. 29 (11), pp. 1403-1406. Date of Electronic Publication: 2019 Mar 22.
Zobrazit plný text záznamu
9
Akademický článek
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
Autor: Johnson CN; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Ahn JS; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Buck IM; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Chiarparin E; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Day JEH; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Hopkins A; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Howard S; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Lewis EJ; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Martins V; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Millemaggi A; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Munck JM; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Page LW; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Peakman T; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Reader M; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Rich SJ; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Saxty G; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Smyth T; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Thompson NT; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Ward GA; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Williams PA; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Wilsher NE; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom., Chessari G; Astex Pharmaceuticals , 436 Cambridge Science Park, Milton Road , Cambridge CB4 0QA , United Kingdom.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Aug 23; Vol. 61 (16), pp. 7314-7329. Date of Electronic Publication: 2018 Aug 09.
Zobrazit plný text záznamu
10
Akademický článek
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.
Autor: Ward GA; Astex Pharmaceuticals, Cambridge, United Kingdom. George.ward@astx.com., Lewis EJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Ahn JS; Astex Pharmaceuticals, Cambridge, United Kingdom., Johnson CN; Astex Pharmaceuticals, Cambridge, United Kingdom., Lyons JF; Astex Pharmaceuticals, Cambridge, United Kingdom., Martins V; Astex Pharmaceuticals, Cambridge, United Kingdom., Munck JM; Astex Pharmaceuticals, Cambridge, United Kingdom., Rich SJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Smyth T; Astex Pharmaceuticals, Cambridge, United Kingdom., Thompson NT; Astex Pharmaceuticals, Cambridge, United Kingdom., Williams PA; Astex Pharmaceuticals, Cambridge, United Kingdom., Wilsher NE; Astex Pharmaceuticals, Cambridge, United Kingdom., Wallis NG; Astex Pharmaceuticals, Cambridge, United Kingdom., Chessari G; Astex Pharmaceuticals, Cambridge, United Kingdom.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2018 Jul; Vol. 17 (7), pp. 1381-1391. Date of Electronic Publication: 2018 Apr 25.
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje