Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Wilna J Moree"'
Autor:
Samantha J Mascuch, Wilna J Moree, Cheng-Chih Hsu, Gregory G Turner, Tina L Cheng, David S Blehert, A Marm Kilpatrick, Winifred F Frick, Michael J Meehan, Pieter C Dorrestein, Lena Gerwick
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119668 (2015)
White-nose syndrome (WNS) caused by the pathogenic fungus Pseudogymnoascus destructans is decimating the populations of several hibernating North American bat species. Little is known about the molecular interplay between pathogen and host in this di
Externí odkaz:
https://doaj.org/article/98305b9b6f1e4535b2dc586698fd1609
Autor:
Wilna J. Moree, Ujwal Patil, Navin Varadarajan, Sujina Mali, Steven J. Bark, Balakrishnan Ramesh, Shaza Abnouf
Publikováno v:
ACS chemical biology. 14(12)
We have engineered the substrate specificity of chymotrypsin to cleave after Asn by high-throughput screening of large libraries created by comprehensive remodeling of the substrate binding pocket. The engineered variant (chymotrypsiN, ChyB-Asn) demo
Autor:
X. Zhao, Jayashree Srinivasan, Wilna J. Moree, Ronnie G. Gavilan, Wei-Ting Liu, Laura M. Sanchez, Pieter C. Dorrestein, Marcelino Gutiérrez, Yu-Liang Yang, Hector M. Guzman, Librada A. Atencio, Don D. Nguyen, Javier Ballesteros, William H. Gerwick, Oliver J. McConnell, Paul D. Boudreau, Daniel Torres-Mendoza
Publikováno v:
ACS Chemical Biology
ACS chemical biology, vol 9, iss 10
ACS chemical biology, vol 9, iss 10
Coral reefs are intricate ecosystems that harbor diverse organisms, including 25% of all marine fish. Healthy corals exhibit a complex symbiosis between coral polyps, endosymbiotic alga, and an array of microorganisms, called the coral holobiont. Sec
Autor:
Marcelino Gutiérrez, Pieter C. Dorrestein, X. Zhao, Wei-Ting Liu, Wilna J. Moree, Jane Y. Yang, Joel Sanchez, Marystella Aparicio, Librada A. Atencio, Javier Ballesteros, Ronnie G. Gavilan
Publikováno v:
Journal of Chemical Ecology. 39:1045-1054
Fungal infections are increasing worldwide, including in the aquatic environment. Microbiota that coexist with marine life can provide protection against fungal infections by secretion of metabolites with antifungal properties. Our laboratory has dev
Autor:
Vanessa V. Phelan, Wilna J. Moree, Theodore Alexandrov, Cheng-Chih Hsu, Jeramie D. Watrous, Pieter C. Dorrestein, Brendan M. Duggan
Publikováno v:
The ISME Journal; Vol 7
Mono- and multispecies microbial populations alter the chemistry of their surrounding environments during colony development thereby influencing multicellular behavior and interspecies interactions of neighboring microbes. Here we present a methodolo
Publikováno v:
Analytical biochemistry. 515
Co-affinity purification mass spectrometry (CoAP-MS) is a highly effective method for identifying protein complexes from a biological sample and inferring important interactions, but the impact of the solid support is usually not considered in design
Autor:
Wilna J. Moree, Paul D. Crowe, Jianyun Wen, Siobhan Malany, Fabio C. Tucci, Sam R. J. Hoare, Melissa Arellano, Graham Beaton, Bin-Feng Li, Jinghua Yu, Joe A. Tran, Satheesh B. Ravula, Robert E. Petroski, Ajay Madan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:421-426
The structure–activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles, 2-morpholine and 2-thiomorpholin-2-yl-1H-benzimidazoles are described. In the lead optimization process, the pKa and/or log P of benzimidazole analogs were reduced either
Publikováno v:
Scientific Reports
Antigen retrieval agents improve the detection of formaldehyde-fixed proteins, but how they work is not well understood. We demonstrate that formaldehyde scavenging represents a key characteristic associated with effective antigen retrieval; under co
Autor:
Paul D. Crowe, Said Zamani-Kord, Bin-Feng Li, Sam R. J. Hoare, Hua Wang, Charles Q. Huang, Siobhan Malany, Wilna J. Moree, Ajay Madan, Fabio C. Tucci, Graham Beaton, Chun Yang, Jianyun Wen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:947-951
Structure–activity relationship studies were conducted to reduce CYP2D6-mediated metabolism in a series of indene H1-antihistamines. Reductions in pKa via incorporation of a β-fluoro substituent or a heteroaryl moiety were shown to reduce contribu
Autor:
Graham Beaton, Phyllis Goldman, Edward A. Kesicki, Anthony J. Demaggio, Wilna J. Moree, Erik Christenson, John Eksterowicz, David L. Mcelligott, Dan Herendeen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5126-5129
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a ce