The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.

Autor: Keuper-Navis M; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands., Walles M; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland., Poller B; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland., Myszczyszyn A; Faculty of Veterinary Medicine & Regenerative Medicine Center Utrecht (RMCU), Utrecht University, Utrecht, the Netherlands., van der Made TK; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands., Donkers J; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the Netherlands., Eslami Amirabadi H; AZAR Innovations, Utrecht, the Netherlands., Wilmer MJ; Cell4Pharma, Oss, the Netherlands., Aan S; Stichting Proefdiervrij, Den Haag, the Netherlands., Spee B; Faculty of Veterinary Medicine & Regenerative Medicine Center Utrecht (RMCU), Utrecht University, Utrecht, the Netherlands., Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands., van de Steeg E; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: Evita.vandesteeg@tno.nl.

Publikováno v: Pharmacological research [Pharmacol Res] 2023 Sep; Vol. 195, pp. 106853. Date of Electronic Publication: 2023 Jul 18.

Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia.

Autor: Vriend J; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: jelle.vriend@radboudumc.nl., Peters JGP; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Nieskens TTG; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Škovroňová R; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Blaimschein N; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Schmidts M; Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Center for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg University Faculty of Medicine, Freiburg, Germany., Roepman R; Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Schirris TJJ; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Systems Biology and Bioenergetics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, The Netherlands., Russel FGM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Systems Biology and Bioenergetics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, The Netherlands., Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands., Wilmer MJ; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2020 Jan; Vol. 1864 (1), pp. 129433. Date of Electronic Publication: 2019 Sep 11.

Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells.

Autor: Vriend J; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Hoogstraten CA; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands.; Centre for Systems Biology and Bioenergetics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Venrooij KR; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., van den Berge BT; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Govers LP; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., van Rooij A; Department of Laboratory Medicine, Translational Metabolic Laboratory (TML), Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Huigen MCDG; Department of Laboratory Medicine, Translational Metabolic Laboratory (TML), Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Schirris TJJ; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands.; Centre for Systems Biology and Bioenergetics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Russel FGM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands.; Centre for Systems Biology and Bioenergetics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands., Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, NL-3584CG, Utrecht, The Netherlands., Wilmer MJ; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500HB, Nijmegen, The Netherlands.

Publikováno v: Biological chemistry [Biol Chem] 2019 Sep 25; Vol. 400 (10), pp. 1347-1358.

Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening.

Autor: Fedecostante M; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Westphal KGC; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Buono MF; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Sanchez Romero N; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Wilmer MJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Kerkering J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Baptista PM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Hoenderop JG; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.)., Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands (M.F., K.G.C.W., M.F.B., N.S.R., R.M.); Aragon's Health Science Institutes (IACS), Zaragoza, Spain (N.S.M.); Departments of Pharmacology and Toxicology (M.J.W., J.K.) and Physiology (J.G.H.), Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands; Aragon Health Research Institute (IIS Aragon), Zaragoza, Spain (P.M.B.); Liver and Digestive Diseases Networking Biomedical Research Centre (CIBERehd), Madrid, Spain (P.M.B.); Jiménez Díaz Foundation Health Research Institute, Madrid, Spain (P.M.B.); and Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid, Spain (P.M.B.) r.masereeuw@uu.nl.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2018 Sep; Vol. 46 (9), pp. 1338-1350. Date of Electronic Publication: 2018 Jul 06.

Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study.

Autor: Suter-Dick L; School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, 4132, Muttenz, Switzerland. laura.suterdick@fhnw.ch., Mauch L; School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, 4132, Muttenz, Switzerland., Ramp D; School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, 4132, Muttenz, Switzerland., Caj M; School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, 4132, Muttenz, Switzerland., Vormann MK; MIMETAS B.V., JH Oortweg 19, 2333 CH, Leiden, The Netherlands., Hutter S; MIMETAS B.V., JH Oortweg 19, 2333 CH, Leiden, The Netherlands., Lanz HL; MIMETAS B.V., JH Oortweg 19, 2333 CH, Leiden, The Netherlands., Vriend J; Department of Pharmacology and Toxicology, Radboudumc, P.O. box 9101, 6500 HB, Nijmegen, The Netherlands., Masereeuw R; Div. Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands., Wilmer MJ; Department of Pharmacology and Toxicology, Radboudumc, P.O. box 9101, 6500 HB, Nijmegen, The Netherlands.

Publikováno v: The AAPS journal [AAPS J] 2018 Jul 23; Vol. 20 (5), pp. 86. Date of Electronic Publication: 2018 Jul 23.