Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Wilma M. McKoy"'
Publikováno v:
Journal of Biological Chemistry. 272:5774-5782
To understand the subcellular localization of the vitamin D receptor (VDR) and to measure VDR content in single cells, we recently developed a fluorescent labeled ligand, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-calcitriol. This tagged hor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b64591c7047410f901fc168f7686a47
https://doi.org/10.1074/jbc.272.9.5774
https://doi.org/10.1074/jbc.272.9.5774
Autor:
Julia Barsony, Wilma M. McKoy
Publikováno v:
Journal of Biological Chemistry. 267:24457-24465
With a recently developed method we detected rapid and sequential reorganization of vitamin D receptors (VDR), including their temporary association with fibers, and we showed that calcitriol induces cGMP accumulation around reorganizing VDRs. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3f08cb537d144ce67fd8c56762ab70c
https://doi.org/10.1016/s0021-9258(18)35788-0
https://doi.org/10.1016/s0021-9258(18)35788-0
Autor:
Richard P. Haugland, Catharine L. Smith, Wilma M. McKoy, Istvan Renyi, Julia Barsony, Hee Choi Kang
Publikováno v:
Analytical biochemistry. 229(1)
To gain better insight into the mechanism of steroid receptor activation and calcitriol action, we have developed the first pharmacologically relevant fluorescent-labeled ligand for the vitamin D receptor (VDR). Purity and structure of three BODIPY-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c335c9079e59dce6137505d643b850
https://pubmed.ncbi.nlm.nih.gov/8533897
https://pubmed.ncbi.nlm.nih.gov/8533897
Autor:
Takashi Tsuruo, Karen R. Grotzinger, Thomas C. Hamilton, Wilma M. McKoy, Karen G. Louie, Robert F. Ozols, Brent C. Behrens, Robert C. Young
Publikováno v:
Investigational New Drugs. 4:295-304
Tricyclic nucleoside 5'-phosphate (TCN-P) was evaluated in two models of human ovarian cancer. TCN-P reduced both colony number and volume in clonogenic assays employing human ovarian cancer cell lines. TCN-P cytotoxicity depended on the concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929e2ea758b2f4511a49b639b216514c
https://doi.org/10.1007/bf00173502
https://doi.org/10.1007/bf00173502
Publikováno v:
Blood. 43:841-846
Sixteen bone marrow aspirates from normal males, cultured in vitro at various concentrations, were compared with ten aspirates from normal females. Marrow from males produced a significantly higher colony count than females when plated at a standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e92b60b3c566f0123676de3fc325cb8
https://doi.org/10.1182/blood.v43.6.841.841
https://doi.org/10.1182/blood.v43.6.841.841
Publikováno v:
Endocrinology. 124:339-345
Tumor necrosis factor-alpha (TNF alpha) and interferon-gamma (IFN gamma) have potent effects on bone resorption and collagen synthesis in cultured rat long bones. Since the effects of TNF alpha and IFN gamma may result from interaction with multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca0c7f09159ed5b7bdccacd6ab76713
https://doi.org/10.1210/endo-124-1-339
https://doi.org/10.1210/endo-124-1-339
Publikováno v:
Cancer Chemotherapy and Pharmacology. 22
The clinical utility of adriamycin in the treatment of patients with metastatic breast cancer is often-limited by the development of drug resistance. It has been recognized that in addition to the development of primary resistance against adriamycin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc041fe45a8199be8b25a91cf26aaf5
https://doi.org/10.1007/bf00257313
https://doi.org/10.1007/bf00257313
Autor:
Thomas C. Hamilton, Charles E. Myers, Robert F. Ozols, Wilma M. McKoy, Robert C. Young, Karen R. Grotzinger, Brent C. Behrens, Karen G. Louie
Publikováno v:
Cancer chemotherapy and pharmacology. 18(2)
Combination chemotherapy regimens have produced a pathological complete response rate of only 1%-25% in patients with advanced ovarian cancer. Patients with small-volume residual disease after treatment are refractory to further systemic therapy, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797d2383bdf8cf28d0ff6c99b5ada31f
https://pubmed.ncbi.nlm.nih.gov/3466726
https://pubmed.ncbi.nlm.nih.gov/3466726
Autor:
Thomas C. Hamilton, Wilma M. McKoy, Gerald Batist, Margaret A. Winker, Karen G. Louie, Karen R. Grotzinger, Brent C. Behrens, Takashi Tsuruo, Robert C. Young, Robert F. Ozols
Publikováno v:
Biochemical pharmacology. 34(14)
The development of acquired resistance to antineoplastic drugs and the associated broad cross-resistance to other agents frequently limits the effectiveness of chemotherapy. Ling and coworkers have demonstrated that Chinese hamster ovary (CHO) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3000688ca08513635dee8d667977cf1
https://pubmed.ncbi.nlm.nih.gov/4040369
https://pubmed.ncbi.nlm.nih.gov/4040369