Degree and site of chromosomal instability define its oncogenic potential

Autor: Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely depende

Externí odkaz: https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626

Degree and site of chromosomal instability define its oncogenic potential

Autor: Bastiaan van Gerwen, Aniek Janssen, Nico Lansu, Nannette Jelluma, Huiying Ma, Sjoerd J. Klaasen, G. Johan A. Offerhaus, Wilma H. M. Hoevenaar, René H. Medema, Antoinette Teixeira, Ajit I. Quirindongo, Folkert H.M. Morsink, Geert J. P. L. Kops

Publikováno v: Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature communications, 11(1):1501. Nature Publishing Group

Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc420f5030dfd4d9453dee67bf91194
https://pure.knaw.nl/portal/en/publications/063362bd-942f-4f69-bda1-4dbddc1b2dcc