Výsledky vyhledávání - "Wilma H M Hoevenaar"

Akademický článek

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

Autor: Alastair Copland, Gillian M Mackie, Lisa Scarfe, Elizabeth Jinks, David A J Lecky, Nancy Gudgeon, Riahne McQuade, Masahiro Ono, Manja Barthel, Wolf-Dietrich Hardt, Hiroshi Ohno, Wilma H M Hoevenaar, Sarah Dimeloe, David Bending, Kendle M Maslowski

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 12, Pp 3057-3088 (2024)

Abstract Bacterial cancer therapy (BCT) is a promising therapeutic for solid tumours. Salmonella enterica Typhimurium (STm) is well-studied amongst bacterial vectors due to advantages in genetic modification and metabolic adaptation. A longstanding p

Externí odkaz: https://doaj.org/article/c6c0ef49a7a64b2b9004b01d4c713943

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Akademický článek

Degree and site of chromosomal instability define its oncogenic potential

Autor: Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely depende

Externí odkaz: https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626

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Emerging immunotherapies for metastasis

Autor: Wilma H. M. Hoevenaar, Seth B. Coffelt, Sarah C. Edwards

Publikováno v: British Journal of Cancer

Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce64f4694211717db1020a12b784ae2
https://doi.org/10.1038/s41416-020-01160-5

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Degree and site of chromosomal instability define its oncogenic potential

Autor: Bastiaan van Gerwen, Aniek Janssen, Nico Lansu, Nannette Jelluma, Huiying Ma, Sjoerd J. Klaasen, G. Johan A. Offerhaus, Wilma H. M. Hoevenaar, René H. Medema, Antoinette Teixeira, Ajit I. Quirindongo, Folkert H.M. Morsink, Geert J. P. L. Kops

Publikováno v: Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature communications, 11(1):1501. Nature Publishing Group

Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc420f5030dfd4d9453dee67bf91194
https://pure.knaw.nl/portal/en/publications/063362bd-942f-4f69-bda1-4dbddc1b2dcc