Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Wilma E. Donker-Koopman"'
Autor:
Judith Klumperman, Tineke Veenendaal, Arthur J. Verhoeven, Marc J. Tol, Wilma E. Donker-Koopman, Johannes M. F. G. Aerts, Jacob Hagen, Saskia Scheij, Carmen Argmann, Martijn J.C. van der Lienden, Marco van Eijk, Hermen S. Overkleeft, Tanit L. Gabriel
Publikováno v:
Autophagy, 14(3), 437-449. Landes Bioscience
Autophagy
Autophagy, 14(3), 437-449
Autophagy
Autophagy, 14(3), 437-449
In recent years, the lysosome has emerged as a highly dynamic, transcriptionally regulated organelle that is integral to nutrient-sensing and metabolic rewiring. This is coordinated by a lysosome-to-nucleus signaling nexus in which MTORC1 controls th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2455e671819669ada8b7a5e0fe53f5
https://pure.amc.nl/en/publications/hepes-activates-a-mittfedependent-lysosomalautophagic-gene-network-in-cultured-cells-a-call-for-caution(2dc148fe-8d83-424a-ae70-46d8ce4fa343).html
https://pure.amc.nl/en/publications/hepes-activates-a-mittfedependent-lysosomalautophagic-gene-network-in-cultured-cells-a-call-for-caution(2dc148fe-8d83-424a-ae70-46d8ce4fa343).html
Autor:
Sascha Hoogendoorn, Hans van den Elst, Gijsbert A. van der Marel, Richard J. B. H. N. van den Berg, Anneke Strijland, Johannes M. F. G. Aerts, Elliot D. Mock, Wilma E. Donker-Koopman, Herman S. Overkleeft
Publikováno v:
European Journal of Organic Chemistry. 2015:4437-4446
N-alkyl-deoxynojirimycins (DNMs) are an important class of glycoprocessing enzyme inhibitors. Our work on DNMs focuses on identifying potent and selective inhibitors of the human enzymes, glucosylceramide synthase (GCS), lysosomal glucosylceramidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7811e99f07322d0c9f445fc424c232e
https://doi.org/10.1002/ejoc.201500364
https://doi.org/10.1002/ejoc.201500364
Autor:
Adrianus M. C. H. van den Nieuwendijk, Daniel Mink, Veronica Coco Rohde, Gijsbert A. van der Marel, Jianbing Jiang, Daniel W. Wright, Bogdan I. Florea, Johannes M. F. G. Aerts, Gideon J. Davies, Wouter W. Kallemeijn, Hans van den Elst, Wilma E. Donker-Koopman, Martin Schürmann, Nan Li, Rolf G. Boot, Saskia Scheij, Marri Verhoek, Jeroen D. C. Codée, Herman S. Overkleeft, Elisa Colomina Folch
Publikováno v:
CHEMICAL SCIENCE, 6(5), 2782-2789. Royal Society of Chemistry
Chemical Science, 6(5), 2782-2789
Chemical Science, 6(5), 2782-2789
GH29 alpha-L-fucosidases catalyze the hydrolysis of alpha-L-fucosidic linkages. Deficiency in human lysosomal alpha-L-fucosidase (FUCA1) leads to the recessively inherited disorder, fucosidosis. Herein we describe the development of fucopyranose-conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c1b0655d1799327f935b9d7fee32e0
https://doi.org/10.1039/c4sc03739a
https://doi.org/10.1039/c4sc03739a
Autor:
Anneke Strijland, Amar B. T. Ghisaidoobe, Maria J. Ferraz, Tom Wennekes, Gijsbert A. van der Marel, Erwin R. van Rijssel, Johannes M. F. G. Aerts, Sascha Hoogendoorn, Herman S. Overkleeft, Wilma E. Donker-Koopman, Kimberly M. Bonger, Jeroen D. C. Codée, Judith H.P.M. Houben, Richard J. B. H. N. van den Berg
Publikováno v:
ChemMedChem, 10(12), 2042. John Wiley and Sons Ltd
ChemMedChem : chemistry enabling drug discovery 10 (2015) 12
ChemMedChem : chemistry enabling drug discovery, 10(12), 2042-2062
ChemMedChem, 10(12), 2042-2062. John Wiley and Sons Ltd
ChemMedChem : chemistry enabling drug discovery 10 (2015) 12
ChemMedChem : chemistry enabling drug discovery, 10(12), 2042-2062
ChemMedChem, 10(12), 2042-2062. John Wiley and Sons Ltd
Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicinal chemistry, because aberrations in the levels of glycolipids that are derived from glucosylceramide are causative in a range of human diseases includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e8efb22414a42f400dad27904710df
https://doi.org/10.1002/cmdc.201500407
https://doi.org/10.1002/cmdc.201500407
Autor:
Saskia Scheij, Richard J. B. H. N. van den Berg, Wilma E. Donker-Koopman, Mark Leemhuis, Anneke Strijland, Tom Wennekes, Saleem S Butt, Amar B. T. Ghisaidoobe, Gijsbert A. van der Marel, Herman S. Overkleeft, Arnold van Loevezijn, Mario van der Stelt, Constant A. A. van Boeckel, Gerrit-Jan Koomen, Adrianus M. C. H. van den Nieuwendijk, Johannes M. F. G. Aerts
Publikováno v:
Journal of medicinal chemistry, 57(21), 9096-9104. American Chemical Society
This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on our previous work, we synthesized a series of D-gluco and L-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d656b24065d8c0333320542ef08a724f
https://doi.org/10.1021/jm501181z
https://doi.org/10.1021/jm501181z
Autor:
Rolf G. Boot, Bogdan I. Florea, Jeroen D. C. Codée, Wilma E. Donker-Koopman, Benjamin Murray, Saskia Scheij, Wouter W. Kallemeijn, Marri Verhoek, Herman S. Overkleeft, Johannes M. F. G. Aerts, Thomas J. M. Beenakker, Gijsbert A. van der Marel, Lianne I. Willems, Maria J. Ferraz, Erwin R. van Rijssel
Publikováno v:
Journal of the American Chemical Society, 136(33), 11622-11625. American Chemical Society
Lysosomal degradation of glycosphingolipids is mediated by the consecutive action of several glycosidases. Malfunctioning of one of these hydrolases can lead to a lysosomal storage disorder such as Fabry disease, which is caused by a deficiency in α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1757c3ffcec39116e9bfc8ac48e3911
https://doi.org/10.1021/ja507040n
https://doi.org/10.1021/ja507040n
Autor:
Johannes M. F. G. Aerts, Marri Verhoek, Timothy M. Cox, Elena Pavlova, Wilma E. Donker-Koopman, Rolf G. Boot, Jessica K. Nelson, Gert Jan Kramer, Wouter W. Kallemeijn, Mary Teresa Moran, Wouter Wegdam, Roelof Ottenhoff, Jon D. Laman, Marco van Eijk, Paulo Gaspar, Tanit L. Gabriel, Johannes P. C. Vissers
Publikováno v:
FEBS Open Bio
FEBS Open Bio, 6(9), 902-913. Wiley-Blackwell
FEBS Open Bio, 6(9), 902-913. Wiley Open Access
FEBS open bio, 6(9), 902-913. Wiley-Blackwell
FEBS Open Bio, 6(9), 902-913. Wiley-Blackwell
FEBS Open Bio, 6(9), 902-913. Wiley Open Access
FEBS open bio, 6(9), 902-913. Wiley-Blackwell
Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was also e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9904b801f366cbc06c3d1033778f123c
https://www.repository.cam.ac.uk/handle/1810/289591
https://www.repository.cam.ac.uk/handle/1810/289591
Autor:
Amar B. T. Ghisaidoobe, Herman S. Overkleeft, Tom Wennekes, Johannes M. F. G. Aerts, Gijsbert A. van der Marel, Richard J. B. H. N. van den Berg, Wilma E. Donker-Koopman, Rolf G. Boot, Anneke Strijland
Publikováno v:
ACS medicinal chemistry letters, 2(7), 519-522. American Chemical Society
ACS Medicical Chemistry Letters 2 (2011) 7
ACS Medicical Chemistry Letters, 2(7), 519-522
ACS Medicical Chemistry Letters 2 (2011) 7
ACS Medicical Chemistry Letters, 2(7), 519-522
Glucosylceramide synthase (GCS) is an approved drug target for the treatment of Gaucher disease and is considered as a valid target for combating other human pathologies, including type 2 diabetes. The clinical drug N-butyldeoxynojirimycin (Zavesca)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b6733dc64247d59fc415f8f82691f7
https://doi.org/10.1021/ml200050s
https://doi.org/10.1021/ml200050s
Autor:
Arjan C. J. de Bruijn, Frithjof D. Godschalk, Marieke C. Guijt, Peter Hagens, Rolf G. Boot, Anneke Strijland, Amar B. T. Ghisaidoobe, Mark Wijzenbroek, Steven M. van't Hart, Gijs A. van der Marel, Eva Rogaar, Johannes M. F. G. Aerts, Wilma E. Donker-Koopman, Vincent H. S. van Rixel, Herman S. Overkleeft, Stijn B. Luitjens, Richard J. B. H. N. van den Berg, Jerre M. Halma, Pieter Bikker, Thor Zweegers
Publikováno v:
ACS medicinal chemistry letters, 2(2), 119-123. American Chemical Society
Glucosylceramide synthase (GCS) is an important target for clinical drug development for the treatment of lysosomal storage disorders and a promising target for combating type 2 diabetes. Iminosugars are useful leads for the development of GCS inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdef980a9afc1194d9b941d6bb0267d
https://doi.org/10.1021/ml100192b
https://doi.org/10.1021/ml100192b
Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism
Autor:
Richard J. B. H. N. van den Berg, Tom Wennekes, Bastiaan Kuijper, Johannes M. F. G. Aerts, Thomas J. Boltje, Wilma E. Donker-Koopman, Anneke Strijland, Gijsbert A. van der Marel, Carlo P. Verhagen, Herman S. Overkleeft
Publikováno v:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010(7), 1258-1283. Wiley-VCH Verlag
The structure–activity relationship of lipophilic aza-C-glycosides as inhibitors of the three enzymes of glucosylceramide metabolism is investigated. A library of β-aza-C-glycosides was synthesized with variations in N-alkylation and the linker le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58b655d6006d688eb53f88b87f4515e
https://doi.org/10.1002/ejoc.200901208
https://doi.org/10.1002/ejoc.200901208