Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Willy Teng"'
Autor:
Wenhao Li, Brian Huang, Willy Teng, Chhaya Bhakta, Uma Sinha, Lane A. Clizbe, Gary Park, Paul W. Wong, Yonghong Song, Bing-Yan Zhu, Robert M. Scarborough, Andrea Reed
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2043-2046
To overcome the low bioavailability of our substituted acrylamide P1 benzamidine factor Xa inhibitors reported previously, neutral and less basic groups were used to replace the benzamidine. As a result, a series of P1 aminoisoquinoline substituted a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3012afd60d7c2309311fb94b54171650
https://doi.org/10.1016/s0960-894x(02)00304-9
https://doi.org/10.1016/s0960-894x(02)00304-9
Autor:
Veronica L. Alves, Brian D. Blackhart, Donna Oksenberg, Elwood E. Reynolds, Robert M. Scarborough, Willy Teng, Chin-Chun Lu, Lily Ruslim-Litrus
Publikováno v:
Molecular Pharmacology. 58:1178-1187
The protease-activated thrombin receptor-1 (PAR-1) can be activated by both the tethered ligand exposed by thrombin cleavage and a synthetic peptide having the tethered ligand sequence (thrombin receptor agonist peptide or TRAP). We conducted a mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0f818f395ce69dcdf3e43df1ecc464
https://doi.org/10.1124/mol.58.6.1178
https://doi.org/10.1124/mol.58.6.1178
Autor:
Willy Teng, Dat Nguyen, Johan Sundelin, Kjell Emilsson, Robert M. Scarborough, Sverker Nystedt, Brian D. Blackhart, Arnold J. Martelli
Publikováno v:
Journal of Biological Chemistry. 271:16466-16471
Recently, a second member of the protease-activated receptor (PAR) family, named PAR-2, has been identified. Similar to the thrombin receptor, PAR-2 appears to be activated by proteolytic-mediated exposure of a "tethered ligand" sequence and can also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a07c5d916851cc961d65a4c63761f5
https://doi.org/10.1074/jbc.271.28.16466
https://doi.org/10.1074/jbc.271.28.16466
Autor:
Israel F. Charo, Willy Teng, M. A. Naughton, Robert M. Scarborough, L. Nannizzi, David R. Phillips, A.M. Campbell, A. Arfsten, J. W. Rose
Publikováno v:
Journal of Biological Chemistry. 268:1066-1073
Members of the snake venon-derived, "disintegrin" peptide family containing the Arg-Gly-Asp (RGD) amino acid sequence are among the most potent inhibitors of the binding of adhesive proteins to platelet glycoprotein (GP) IIb-IIIa. However, GPIIb-IIIa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91081ae25e97036bb9d3bbdbc60d0fa7
https://doi.org/10.1016/s0021-9258(18)54042-4
https://doi.org/10.1016/s0021-9258(18)54042-4
Autor:
Willy Teng, M. A. Naughton, J. W. Rose, Deborah T. Hung, T.-K. H. Vu, C. W. Turck, Robert M. Scarborough, V. I. Wheaton, Shaun R. Coughlin
Publikováno v:
Journal of Biological Chemistry. 267:13146-13149
The human platelet thrombin receptor is activated when thrombin cleaves its receptor's amino-terminal extension to reveal a new amino terminus that functions as a tethered peptide ligand. Exactly how this "agonist peptide domain" remains cryptic with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe46fa62d4ea3b82ccbd8884d0fb1d6f
https://doi.org/10.1016/s0021-9258(18)42184-9
https://doi.org/10.1016/s0021-9258(18)42184-9
Autor:
Katherine Tran, Gary Park, Paul W. Wong, Andrea Reed, Robert M. Scarborough, Lane A. Clizbe, Bing Yan Zhu, Uma Sinha, Chhaya Bhakta, Brian Huang, Willy Teng, Yonghong Song
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(2)
In addition to our previously reported fluoro acrylamides Xa inhibitors 2 and 3 , a series of potent and novel cyclic diimide amidine compounds has been identified. In efforts to improve their oral bioavailability, replacement of the amidine group wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9bae6d31f082e56b38b2ce5c2572e9
https://pubmed.ncbi.nlm.nih.gov/12482444
https://pubmed.ncbi.nlm.nih.gov/12482444
Autor:
Katherine Tran, Robert M. Scarborough, Yanhong Wu, Ting Su, Willy Teng, Andrea Reed, Brian Huang, Uma Sinha, Penglie Zhang, Paul W. Wong, James Kanter, Brandon Doughan, Lingyan Wang, Yonghong Song, Bing-Yan Zhu, Wenhao Li, John Malinowski, Stan Hollenbach, Chhaya Bhakta, Zhaozhong Jon Jia, Gary Park, Lane A. Clizbe, John Woolfrey
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(11)
Substituted acrylamides were used as templates that bridge P1 and P4 binding elements, resulting in a series of potent (sub-nanomolar) and selective factor Xa inhibitors. In this template, cis-geometry of P1 and P4 ligands is highly preferred. SAR on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a45d36b387386ebbfa24a4b70f76a7f
https://pubmed.ncbi.nlm.nih.gov/12031331
https://pubmed.ncbi.nlm.nih.gov/12031331
Publikováno v:
Peptides ISBN: 9789401042956
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5d0cf4f4d663c58885834a2c856f294
https://doi.org/10.1007/978-94-011-0683-2_230
https://doi.org/10.1007/978-94-011-0683-2_230
