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Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor

Autor: Urs Eppenberger, Serenella Eppenberger-Castori, Jonas Cicenas, Willy Küng

Publikováno v: Cancers
Cancers, Vol 2, Iss 1, Pp 153-164 (2010)
Volume 2
Issue 1
Pages 153-164

The SH2 domain-containing adaptor protein ShcA is a proto-oncogene involved in growth factor receptor signaling. The role of phosphorylated ShcA is to link receptor tyrosine kinases with the SH2-containing adaptor protein Grb2, thus facilitating sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9e6a7c9aade25e0c42ca744cea9de5
https://doi.org/10.3390/cancers2010153

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EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells

Autor: Richard Herrmann, Christoph Mamot, Christoph Rochlitz, Reto Ritschard, Willy Küng, John W. Park

Publikováno v: Journal of Drug Targeting. 14:215-223

We hypothesized that immunoliposomes (ILs) constructed using Fab' from the humanized anti-EGFR monoclonal antibody, EMD72000, can provide efficient intracellular drug delivery in EGFR-overexpressing colorectal tumor cells.ILs were constructed modular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec68fac21ac6edb349bc357a84ac0876
https://doi.org/10.1080/10611860600691049

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Immunoliposomal delivery of doxorubicin can overcome multidrug resistance mechanisms in EGFR-overexpressing tumor cells

Autor: Richard Herrmann, Willy Küng, Christoph Mamot, Andreas Wicki, Christoph Rochlitz, Reto Ritschard, Jan Schuller

Publikováno v: Journal of drug targeting. 20(5)

Immunoliposomes (ILs) can be constructed to target the epidermal growth factor receptor (EGFR) to provide efficient intracellular drug delivery in tumor cells. We hypothesized that this approach might be able to overcome drug resistance mechanisms, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac274c36ffc05b071507b0eebffdcd
https://pubmed.ncbi.nlm.nih.gov/22519893

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Modulation of extracellular-matrix synthesized by cultured stromal cells from normal human breast tissue by epidermal growth factor

Autor: Urs Eppenberger, Timothy Scott-Burden, Willy Küng, Patricia Baley, Irene Lützelschwab

Publikováno v: Journal of Cellular Biochemistry. 43:111-125

A routine, reproducible procedure was developed for the preparation and characterization of stromal cells from normal human breast tissue obtained by reduction mammaplasty. Isolates (n = 15) all exhibited enhanced rates of proliferation, even in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c02c4495ce70e9a03578ae3afaac6
https://doi.org/10.1002/jcb.240430203

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Heregulins implicated in cellular functions other than receptor activation

Autor: Willy Küng, Fabrice Schoumacher, Heinz Mueller, Madlaina Breuleux, Urs Eppenberger, Daniel Rehn

Publikováno v: Molecular cancer research : MCR. 4(1)

Heregulins (HRG) are known as soluble secreted growth factors that, on binding and activating ErbB3 and ErbB4 cell surface receptors, are involved in cell proliferation, metastasis, survival, and differentiation in normal and malignant tissues. Previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc28c83b5e0b3b736325ca9ab17d53e
https://pubmed.ncbi.nlm.nih.gov/16446404

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Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients

Autor: Vincent Vuaroqueaux, Martin Labuhn, Willy Küng, Jonas Cicenas, Serenella Eppenberger-Castori, Urs Eppenberger, Patrick Urban, Edward Wight

Publikováno v: European journal of cancer (Oxford, England : 1990). 42(5)

ERBB2 (HER2/Neu) gene amplification and overexpression is associated with increased risk of metastases and shorter survival in breast cancer. Tyrosine 1248 is a major phosphorylation site of ERBB2 and reflects the activation status of the receptor. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65a616ef7aa44803fe5f30fea21e8fe
https://pubmed.ncbi.nlm.nih.gov/16414259

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Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2

Autor: Vincent Vuaroqueaux, Urs Eppenberger, Jonas Cicenas, Serenella Eppenberger-Castori, Edward Wight, Willy Küng, Mark W. Mayhew, Patrick Urban, Martin Labuhn

Publikováno v: Breast Cancer Research

Introduction Akt1, Akt2 and Akt3 kinases are downstream components of phosphoinositol 3-kinase derived signals from receptor tyrosine kinases, which influence cell growth, proliferation and survival. Akt2 overexpression and amplification have been de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b4d697f99265c8cfc6091da609ca5d
https://pubmed.ncbi.nlm.nih.gov/15987444

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Isolation of a heregulin-like growth factor secreted by estrogen receptor-negative MDA-MB-231 human breast cancer cells that stimulates estrogen receptor-positive cells

Autor: E. Silber, Urs Eppenberger, F. David, E.J. Schlaeger, Hans-Werner Lahm, K.A. Weyer, Hanno Langen, Willy Küng, Heinz Mueller

Publikováno v: Biochemical and biophysical research communications. 202(3)

A 52 kDa peptide growth factor secreted by the estrogen receptor (ER)-negative human breast cancer cell line MDA-MB-231 was purified to homogeneity. It induced transient membrane ruffling, lamellipodia formation, cell motility and proliferation exclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97514d9e7da8d18b95fb80bd16f66a19
https://pubmed.ncbi.nlm.nih.gov/8060314

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Inhibition of growth-factor-activated proliferation by anti-estrogens and effects on early gene expression of MCF-7 cells

Autor: Max Hasmann, Katja Dr. Wosikowski, Roland Löser, Willy Küng, Urs Eppenberger

Publikováno v: International journal of cancer. 53(2)

Recently, it was reported that the anti-estrogen tamoxifen not only inhibits estradiol-stimulated growth of MCF-7 cells but also significantly reduces the proliferation rate of cells stimulated by growth factors. We have confirmed this finding and al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecf35e596e136e5c267ac782beae941
https://pubmed.ncbi.nlm.nih.gov/8425767

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