Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Willy Hugo"'
Autor:
Richard G. Everson, Willy Hugo, Lu Sun, Joseph Antonios, Alexander Lee, Lizhong Ding, Melissa Bu, Sara Khattab, Carolina Chavez, Emma Billingslea-Yoon, Andres Salazar, Benjamin M. Ellingson, Timothy F. Cloughesy, Linda M. Liau, Robert M. Prins
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract In this randomized phase II clinical trial, we evaluated the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to autologous tumor lysate-pulsed dendritic cell (ATL-DC) vaccination in patients with newly-diagnosed or recurre
Externí odkaz:
https://doaj.org/article/3d3f4ce1e0b340f7b0779a6e1bdebc9c
Autor:
Richard G. Everson, Willy Hugo, Lu Sun, Joseph Antonios, Alexander Lee, Lizhong Ding, Melissa Bu, Sara Khattab, Carolina Chavez, Emma Billingslea-Yoon, Andres Salazar, Benjamin M. Ellingson, Timothy F. Cloughesy, Linda M. Liau, Robert M. Prins
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e393bc4c03db441e95498e95bf6c4910
Autor:
Lu Sun, Jenny C. Kienzler, Jeremy G. Reynoso, Alexander Lee, Eileen Shiuan, Shanpeng Li, Jiyoon Kim, Lizhong Ding, Amber J. Monteleone, Geoffrey C. Owens, Joanna J. Phillips, Richard G. Everson, David Nathanson, Timothy F. Cloughesy, Gang Li, Linda M. Liau, Willy Hugo, Won Kim, Robert M. Prins
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
In comparison with responses in recurrent glioblastoma (rGBM), the intracranial response of brain metastases (BrM) to immune checkpoint blockade (ICB) is less well studied. Here, we present an integrated single-cell RNA-Seq (scRNA-Seq) study of 19 IC
Externí odkaz:
https://doaj.org/article/3cb05e2876a542d2be72e98032f7abe4
Autor:
Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIncreased T cell infiltration and interferon gamma (IFNγ) pathway activation are seen in tumors of melanoma patients who respond to ICI (immune checkpoint inhibitor) or MAPK pathway inhibitor (MAPKi) therapies. Yet, the rate of durable t
Externí odkaz:
https://doaj.org/article/90773f18c9604dea88e9ab2eb0be4fa5
Autor:
Alexander H. Lee, Lu Sun, Aaron Y. Mochizuki, Jeremy G. Reynoso, Joey Orpilla, Frances Chow, Jenny C. Kienzler, Richard G. Everson, David A. Nathanson, Steven J. Bensinger, Linda M. Liau, Timothy Cloughesy, Willy Hugo, Robert M. Prins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the i
Externí odkaz:
https://doaj.org/article/bc4276916a1e42c19b71f6a03a3eba26
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/47de284bcd5b48128ca88268c518f7d5
Autor:
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is inc
Externí odkaz:
https://doaj.org/article/e438254920ee4e73ba0fa35c8e36bf84
Autor:
Dongyun Zhang, Willy Hugo, Peter Redublo, Hui Miao, Marvin Bergsneider, Marilene B. Wang, Won Kim, William H. Yong, Anthony P. Heaney
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103294- (2021)
Background: Cushing disease (CD), although rare, is a life-threatening disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma, which leads to excess adrenal-derived cortisol. Efficacious and safe medical therapies that c
Externí odkaz:
https://doaj.org/article/2601596e7f584ac4b65e0bb080bf7b79
Autor:
Helena Escuin-Ordinas, Yining Liu, Lu Sun, Willy Hugo, Robert Dimatteo, Rong Rong Huang, Paige Krystofinski, Ariel Azhdam, Jordan Lee, Begoña Comin-Anduix, Alistair J Cochran, Roger S Lo, Tatiana Segura, Philip O Scumpia, Antoni Ribas
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252597 (2021)
Wound healing is a multi-step process to rapidly restore the barrier function. This process is often impaired in diabetic patients resulting in chronic wounds and amputation. We previously found that paradoxical activation of the mitogen-activated pr
Externí odkaz:
https://doaj.org/article/72360e10ae0640ca8f04bc31993c6288
Publikováno v:
Industrial Data, Vol 23, Iss 1 (2020)
En el artículo se propone que el empleo de un modelo de gestión en los principales laboratorios farmacéuticos del Perú favorece el manejo de la cadena de suministro y la rentabilidad de estos. El interés del estudio parte de la preocupación del
Externí odkaz:
https://doaj.org/article/a77266a1ad694371a616d0096c65983f