Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Willy Decurtins"'
Autor:
Micah Steffek, Elizabeth Helgason, Nataliya Popovych, Lionel Rougé, John M. Bruning, Ke Sherry Li, Daniel J. Burdick, Jianping Cai, Terry Crawford, Jing Xue, Willy Decurtins, Chunlin Fang, Felix Grubers, Michael J. Holliday, Allyson Langley, Ann Petersen, Alexander Lee Satz, Aimin Song, Daniel Stoffler, Quentin Strebel, Jeffrey Y. K. Tom, Nicholas Skelton, Steven T. Staben, Moreno Wichert, Melinda M. Mulvihill, Erin C. Dueber
Publikováno v:
Biochemistry. 62:633-644
Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) famil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c00ab7c9a5fb6957dbd609eeeeb525
https://doi.org/10.1021/acs.biochem.1c00682
https://doi.org/10.1021/acs.biochem.1c00682
Autor:
Raphael M. Franzini, Dario Neri, Willy Decurtins, Yixin Zhang, Moreno Wichert, Michael A. Stravs, Jörg Scheuermann, Fabian Buller
Publikováno v:
Nature Protocols
This protocol describes an approach for screening DNA-encoded chemical libraries (DECLs) to identify molecules that bind to proteins of interest. After isolating binding library members, DNA barcodes are amplified and identified by high-throughput se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a683d57f0faee9648e704d15aa934c
https://doi.org/10.1038/nprot.2016.039
https://doi.org/10.1038/nprot.2016.039
Autor:
Jonathan Hall, Florent Samain, Herwig Schüler, Susanne Gräslund, T. Ekblad, Davor Bajic, Nan Zhong, Peter Brown, Mauro Zimmermann, Raphael M. Franzini, Dario Neri, Angela Nauer, Jörg Scheuermann, Willy Decurtins, Gediminas Mikutis
Publikováno v:
Journal of medicinal chemistry
We describe the synthesis and screening of a DNA-encoded chemical library containing 76230 compounds. In this library, sets of amines and carboxylic acids are directly linked producing encoded compounds with compact structures and drug-like propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5594c9abfe32f054f2bce58be4089b
Autor:
Raphael M. Franzini, Moreno Wichert, Francesca Pretto, Nikolaus Krall, Willy Decurtins, Petra Schneider, Jörg Scheuermann, Dario Neri
Publikováno v:
Nature chemistry
Nature Chemistry
Nature Chemistry
In contrast to standard fragment-based drug discovery approaches, dual-display DNA-encoded chemical libraries have the potential to identify fragment pairs that bind simultaneously and benefit from the chelate effect. However, the technology has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30a0e9c75c1949e28ceb3849e726080
Autor:
Dario Neri, Nikolaus Krall, Claudiu T. Supuran, Gonçalo J. L. Bernardes, Willy Decurtins, Francesca Pretto
Publikováno v:
Angewandte Chemie. 126:4315-4320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ac12b47c752b87481ed3f9cc78c609
https://doi.org/10.1002/ange.201310709
https://doi.org/10.1002/ange.201310709
Autor:
Dario Neri, Claudiu T. Supuran, Francesca Pretto, Willy Decurtins, Nikolaus Krall, Gonçalo J. L. Bernardes
Publikováno v:
Angewandte Chemie-International Edition
Antibody drug conjugates are a very promising class of new anticancer agents but the use of small molecule ligands for the targeted delivery of cytotoxic drugs into solid tumors is less well established. Here we describe the first small molecule drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384f3167290a472929b4c1af15f6f64e
https://doi.org/10.1002/anie.201310709
https://doi.org/10.1002/anie.201310709
Autor:
Herwig Schüler, Mauro Zimmermann, Jonathan Hall, T. Ekblad, Moreno Wichert, Willy Decurtins, Nan Zhong, Jörg Scheuermann, Susanne Gräslund, Raphael M. Franzini, Angela Nauer, Florent Samain, Peter Brown, Dario Neri
Publikováno v:
Angewandte Chemie (International ed. in English). 54(13)
Methods for the rapid and inexpensive discovery of hit compounds are essential for pharmaceutical research and DNA-encoded chemical libraries represent promising tools for this purpose. We here report on the design and synthesis of DAL-100K, a DNA-en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ba1300d5a1ffaec03d88d92eac029
https://pubmed.ncbi.nlm.nih.gov/25650139
https://pubmed.ncbi.nlm.nih.gov/25650139
Autor:
Urs F. Greber, Justyna Ruminska, Balázs Harrach, Márton Z. Vidovszky, Sandra Ramelli, Silvio Hemmi, Willy Decurtins
Murine adenoviruses (MAdV) are supposedly the oldest members of the genus Mastadenovirus. Currently, there are three distinct MAdV types known with rather different tropism and pathology. Here we report and annotate the DNA sequence of the full genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42153e0e17bc8b7846bb8b1d46279e4
https://www.zora.uzh.ch/id/eprint/48501/
https://www.zora.uzh.ch/id/eprint/48501/
