Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid

Autor: Willy A. Solis, Brett A. Vaughn, Eszter Boros, Trevor J. Hallam, Mark Lupher, Shin Hye Ahn

Publikováno v: Bioconjugate Chemistry. 31:1177-1187

Antibody–drug conjugates (ADCs) are a class of targeted therapeutics consisting of a monoclonal antibody coupled to a cytotoxic payload. Various bioconjugation methods for producing site-specific A...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9740ae9a8b89b617f64f404c11fb8e90
https://doi.org/10.1021/acs.bioconjchem.0c00100

Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001

Autor: Willy A. Solis, Arturo Molina, Alice Yam, Ryan Stafford, Trevor J. Hallam, Kwun Wah Wen, Mark Lupher, Cristina Abrahams, Christopher Jones, Xiaofan Li, Millicent Embry, Stellanie Krimm, Venita DeAlmeida, Sarah Krueger, Nancy Y. Greenland, Shannon Matheny, Toni Kline, Arun P. Wiita, Abigail Yu

Publikováno v: Oncotarget
Oncotarget, vol 9, iss 102
Abrahams, Cristina L; Li, Xiaofan; Embry, Millicent; Yu, Abigail; Krimm, Stellanie; Krueger, Sarah; et al.(2018). Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001.. Oncotarget, 9(102), 37700-37714. doi: 10.18632/oncotarget.26491. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2rh6994v

STRO-001 is a site-specific, predominantly single-species, fully human, aglycosylated anti-CD74 antibody-drug conjugate incorporating a non-cleavable linker-maytansinoid warhead with a drug-antibody ratio of 2 which was produced by a novel cell-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e1ebe00cf3bb8373f294a334b53ad
https://pubmed.ncbi.nlm.nih.gov/30701025

Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer

Autor: Mark Lupher, Toni Kline, Jeffrey A. Hanson, G. Sarma, V. De Almeida, Xiaolin Li, James Zawada, Willy A. Solis, Cristina Abrahams, Mary Rose Masikat

Publikováno v: Gynecologic Oncology. 149:50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06375687f94d44524e19c5ca66b8161c
https://doi.org/10.1016/j.ygyno.2018.04.109

Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements11Abbreviations: EPRE, electrophile response element; AHRE, aromatic hydrocarbon response element; MRE, metal response element; Nqo1 and NQO1, mouse NAD(P)H:quinone oxidoreductase [also called NMO1, quinone reductase, DT-diaphorase] gene and mRNA; Cyp1a1 and CYP1A1, mouse cytochrome P450 1A1 gene and mRNA; Mt1 and MT1, mouse metallothionein-1 gene and mRNA; Sod, mouse Cu,Zn-superoxide dismutase gene; SOD, rat Cu,Zn-superoxide dismutase gene; SOD, mouse and rat Cu,Zn-superoxide dismutase mRNA and protein; Luc and LUC, firefly luciferase gene and enzyme; BGAL, β-galactosidase enzyme activity; tBHQ, tert-butylhydroquinone; dioxin (also TCDD), 2,3,7,8-tetrahydro chlorodibenzo-p-dioxin; SSC, standard sodium citrate; and SET, sodium ethylenediamine tetraacetic acid (EDTA) Tris buffer

Autor: Daniel W. Nebert, Matthew Z. Dieter, Timothy P. Dalton, Willy A. Solis, Sarah L Freshwater

Publikováno v: Biochemical Pharmacology. 61:215-225

To investigate a possible role of phosphorylation in the signal transduction pathways responsible for transcriptional regulation of drug-metabolizing enzymes, we tested seven specific tyrosine kinase inhibitors (tyrphostins) for their effects on NAD(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b88dd331463ddae19557f1be76db729b
https://doi.org/10.1016/s0006-2952(00)00525-6

Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins

Autor: Alvaro Puga, Willy A. Solis, Daniel W. Nebert, Michael J. Carvan, Larissa V. Ponomareva, Robin S. Matlib

Publikováno v: Marine Biotechnology. 1:155-166

Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this het

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1dae3f7868b81f811ff83be25ede80
https://doi.org/10.1007/pl00011763