The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq

Autor: Wills, QF, Mellado-Gomez, E, Nolan, R, Warner, D, Sharma, E, Broxholme, J, Wright, B, Lockstone, H, James, W, Lynch, M, Gonzales, M, West, J, Leyrat, A, Padilla-Parra, S, Filippi, S, Holmes, C, Moore, MD, Bowden, R

Publikováno v: BMC Genomics

Background Single-cell RNA-Seq can be a valuable and unbiased tool to dissect cellular heterogeneity, despite the transcriptome’s limitations in describing higher functional phenotypes and protein events. Perhaps the most important shortfall with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d7f067e7f4265090dfb2b8adc6b5971d
http://europepmc.org/articles/PMC5219790

Micro-ribonucleic acid expression profiling and expression quantitative trait loci analysis in human gluteal and abdominal adipose tissue

Autor: Rantalainen, M, Herrera, BM, Nicholson, G, Wills, QF, Bowden, R, Neville, MJ, Randall, JC, Barrett, A, Allen, M, McCarthy, MI, Zondervan, KT, Karpe, F, Holmes, CC, Lindgren, CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::437dc7c2479111a164153f5f88c20a69
https://ora.ox.ac.uk/objects/uuid:2e2e859b-c913-49e5-90a5-a2e47910857d

Isoform-level gene expression patterns in single-cell RNA-sequencing data.

Autor: Vu TN; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Wills QF; Novo Nordisk Research Centre Oxford, Oxford, UK., Kalari KR; Department of Health Sciences Research., Niu N; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Wang L; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Pawitan Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Rantalainen M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2018 Jul 15; Vol. 34 (14), pp. 2392-2400.

Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R.

Autor: McCarthy DJ; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, CB10 1SD Hinxton, Cambridge, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; St Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia., Campbell KR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK., Lun AT; CRUK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK., Wills QF; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2017 Apr 15; Vol. 33 (8), pp. 1179-1186.

Statistical approaches and software for clustering islet cell functional heterogeneity.

Autor: Wills QF; a Wellcome Trust Center for Human Genetics, University of Oxford , Oxford , United Kingdom.; b Weatherall Institute of Molecular Medicine, University of Oxford , Oxford , United Kingdom., Boothe T; c Department of Cellular and Physiological Sciences , Life Sciences Center, University of British Columbia , Vancouver , Canada., Asadi A; c Department of Cellular and Physiological Sciences , Life Sciences Center, University of British Columbia , Vancouver , Canada., Ao Z; d Department of Surgery , University of British Columbia , Vancouver , Canada., Warnock GL; d Department of Surgery , University of British Columbia , Vancouver , Canada., Kieffer TJ; c Department of Cellular and Physiological Sciences , Life Sciences Center, University of British Columbia , Vancouver , Canada.; d Department of Surgery , University of British Columbia , Vancouver , Canada., Johnson JD; c Department of Cellular and Physiological Sciences , Life Sciences Center, University of British Columbia , Vancouver , Canada.; d Department of Surgery , University of British Columbia , Vancouver , Canada.

Publikováno v: Islets [Islets] 2016 Mar 03; Vol. 8 (2), pp. 48-56.