Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.

Autor: Wills ES; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands., Te Morsche RHM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands., van Reeuwijk J; Department of Human Genetics and Radboud Insitute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Horn N; Division of Experimental Ophthalmology and Medical Bioanalytics, Center for Ophthalmology, Eberhard-Karls University Tübingen, 72076, Tübingen, Germany., Geomini I; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands., van de Laarschot LFM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands., Mans DA; Department of Human Genetics and Radboud Insitute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Ueffing M; Division of Experimental Ophthalmology and Medical Bioanalytics, Center for Ophthalmology, Eberhard-Karls University Tübingen, 72076, Tübingen, Germany., Boldt K; Division of Experimental Ophthalmology and Medical Bioanalytics, Center for Ophthalmology, Eberhard-Karls University Tübingen, 72076, Tübingen, Germany., Drenth JPH; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands., Roepman R; Department of Human Genetics and Radboud Insitute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Nov 01; Vol. 26 (21), pp. 4190-4202.

Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes.

Autor: Wills ES; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Cnossen WR; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Veltman JA; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands., Woestenenk R; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Steehouwer M; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Salomon J; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands., Te Morsche RH; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands., Huch M; Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge, UK.; Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Hehir-Kwa JY; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Banning MJ; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Pfundt R; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Roepman R; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Hoischen A; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Drenth JP; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2016 Dec; Vol. 24 (12), pp. 1707-1714. Date of Electronic Publication: 2016 Aug 24.

Fecal microbial composition of ulcerative colitis and Crohn's disease patients in remission and subsequent exacerbation.

Autor: Wills ES; School for Nutrition, Toxicology and Metabolism (NUTRIM), Division Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, The Netherlands; School for Nutrition, Toxicology and Metabolism (NUTRIM), Department of Medical Microbiology, Maastricht University Medical Center+, Maastricht, The Netherlands., Jonkers DM; School for Nutrition, Toxicology and Metabolism (NUTRIM), Division Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, The Netherlands., Savelkoul PH; School for Nutrition, Toxicology and Metabolism (NUTRIM), Department of Medical Microbiology, Maastricht University Medical Center+, Maastricht, The Netherlands., Masclee AA; School for Nutrition, Toxicology and Metabolism (NUTRIM), Division Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, The Netherlands., Pierik MJ; School for Nutrition, Toxicology and Metabolism (NUTRIM), Division Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, The Netherlands., Penders J; School for Nutrition, Toxicology and Metabolism (NUTRIM), Department of Medical Microbiology, Maastricht University Medical Center+, Maastricht, The Netherlands; School for Public Health and Primary Care (Caphri), Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.

Publikováno v: PloS one [PLoS One] 2014 Mar 07; Vol. 9 (3), pp. e90981. Date of Electronic Publication: 2014 Mar 07 (Print Publication: 2014).