Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.

Autor: Morley TJ; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville TN.; Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN., Willimitis D; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville TN., Ripperger M; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville TN., Lee H; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston MA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston MA., Han L; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville TN.; Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN., Zhou Y; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston MA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston MA., Kang J; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville TN., Davis LK; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville TN.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville TN.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN., Smoller JW; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston MA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston MA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA., Choi KW; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston MA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston MA., Walsh CG; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville TN.; Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville TN.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN., Ruderfer DM; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville TN.; Center for Digital Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville TN.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 01. Date of Electronic Publication: 2023 Nov 01.