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Autor:
Bruce D. Dorsey, Emilio A. Emini, M. Katharine Holloway, Joan A. Zugay, P. S. Anderson, J. H. Lin, J. L. Chen, Joel R. Huff, James P. Guare, Ken E. Starbuck, Willie Whitter, Stacey L. McDaniel, Hungate Randall W, I.-W. Chen, William A. Schleif, Joseph P. Vacca, Paul L. Darke, Quintero Julio C, Rhonda B. Levin
Publikováno v:
Bioorganicmedicinal chemistry. 2(9)
Incorporation of a γ-lactam in hydroxyethylene isosteres results in modest inhibitors of HIV-1 protease. Additional structural activity studies have produced significantly more potent inhibitors with the introduction of the trisubstituted cyclopenta