Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Willie L. Whitter"'
1
Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product
Autor: Victor M. Garsky, Erb Jm, N. P. Gould, Debra S. Perlow, George F. Lundell, Mark G. Bock, Willie L. Whitter, Peter D. Williams, R. D. Tung, Hoffman Jb
Publikováno v: Journal of Medicinal Chemistry. 35:3905-3918
A new structural class of cyclic hexapeptide oxytocin antagonists derived from Streptomyces silvensis and typified by L-365,209 (cyclo-[L-prolyl1-D-phenylalanyl2-L- isoleucyl3-D-dehydropiperazyl4-L-dehydroperazyl5-D-(N- methyl)phenylalanyl6]) was rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafa0810673efe3c5995b9a199e805fb
https://doi.org/10.1021/jm00099a019
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2
Design of cholecystokinin peptidomimetics
Autor: Kenneth E. Rittle, Raymond S.L. Chang, Daniel F. Veber, Willie L. Whitter, Mark G. Bock, Roger M. Freidinger, Paul S. Anderson, Ben E. Evans, Victor J. Lotti, Robert M. DiPardo
Publikováno v: Journal of Controlled Release. 21:73-80
Cholecystokinin (CCK) is a polypeptide hormone which occurs in numerous molecular forms at various sites throughout the peripheral and central nervous systems. The wide range of physiological responses which have been attributed to CCK has stimulated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::712adf34d6477bb58086f924e7c86a2e
https://doi.org/10.1016/0168-3659(92)90009-g
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3
Cholecystokinin-A receptor ligands based on the .kappa.-opioid agonist tifluadom
Autor: Kenneth E. Rittle, Daniel F. Veber, Roger M. Freidinger, Ben E. Evans, Raymond S. L. Chang, Willie L. Whitter, Victor J. Lotti, Mark G. Bock, Robert M. DiPardo, Tsing-Bau Chen
Publikováno v: Journal of Medicinal Chemistry. 33:450-455
Tifluadom, a kappa-opioid agonist and cholecystokinin-A (CCK-A) receptor antagonist, was utilized as a model to prepare a series of 2-(aminomethyl)- and 3-(aminomethyl)-1,4-benzodiazepines. These compounds were tested in vitro as inhibitors of the bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c979655d204069844fb5b5aa665cabed
https://doi.org/10.1021/jm00163a069
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5
Novel glutamic acid derived cholecystokinin receptor ligands
Autor: Victor J. Lotti, R. S. L. Chang, Roger M. Freidinger, Willie L. Whitter, M. K. Holloway, N. P. Gould
Publikováno v: Journal of medicinal chemistry. 33(2)
Novel aryl amide analogues of glutamic acid dialkylamide have been synthesized to test for a possible structural analogy between glutamic acid and benzodiazepine CCK antagonists such as compounds 2 and 24 (lorglumide and MK-329, respectively). In sup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90821e5e2e6d2f43a0653fc045421565
https://pubmed.ncbi.nlm.nih.gov/2299627
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6
Potent and Selective Oxytocin Antagonists Obtained by Chemical Modification of a Streptomyces Silvensis Derived Cyclic Hexapeptide and by Total Synthesis
Autor: Roger M. Freidinger, R. D. Tung, Jill M. Erb, Willie L. Whitter, Peter D. Williams, Daniel F. Veber, N. P. Gould, Mark G. Bock, Robert M. DiPardo, Debra S. Perlow, George F. Lundell, Douglas J. Pettibone, Richard G. Ball, B. V. Clineschmidt
Publikováno v: Chemical Aspects of Enzyme Biotechnology ISBN: 9781475796391
Oxytocin (OT) is a neurohypophyseal hormone which has an important function in parturition.1 There is considerable evidence that the uterotonic action of OT and its stimulation of uterine prostaglandin release combine to initiate labor.2,3 Additional
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee0a89b1a195dd3cd67d09cbb1b5bd26
https://doi.org/10.1007/978-1-4757-9637-7_11
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8
Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin
Autor: Willie L. Whitter, Kenneth E. Rittle, Daniel F. Veber, Paul S. Anderson, Roger M. Freidinger, Ben E. Evans, Robert M. DiPardo, Mark G. Bock
Publikováno v: Proceedings of the National Academy of Sciences. 83:4918-4922
We describe the design and synthesis of nonpeptidal antagonists of the peptide hormone cholecystokinin. Several of these compounds have high specificity and nanomolar binding affinity and are active after oral administration. To our knowledge, the de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3eb5041502a66d821c6d878f81bb31
https://doi.org/10.1073/pnas.83.13.4918
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10
Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency
Autor: LaMont Bi, Willie L. Whitter, Payne Linda S, Robert M. DiPardo, Joshua S. Boger, B. E. Evans, Kenneth E. Rittle, Roger M. Freidinger, Edgar H. Ulm, Mark G. Bock
Publikováno v: Journal of medicinal chemistry. 31(10)
Nineteen tetrapeptides containing statine (Sta) and 4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) were prepared. Solubility measurements of these compounds were carried out in H2O and in pH 7.4 phosphate buffer solution, and their partition co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e837297dc024ded7187bc66b4fe25b
https://pubmed.ncbi.nlm.nih.gov/3050088
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