Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions

Autor: M. A. Savage, Nizal S. Chandrakumar, Awilda Stapelfeld, Drury B, Williamson Ln, M. Reichman, Beardsley Pm, Anthony Ew, Lopez Ot

Publikováno v: Journal of medicinal chemistry. 35(16)

In order to develop systemically-active opioid peptides, the delta-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Compound 4 was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa0525ffacf05a78c25a52fc2656165
https://pubmed.ncbi.nlm.nih.gov/1323677

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Common deficiencies with bioequivalence submissions in abbreviated new drug applications assessed by FDA.

Autor: Liu Q; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, Rockville, Maryland 20855, USA. qing.liu@fda.hhs.gov, Davit BM, Cherstniakova SA, Dandamudi S, Walters JF, Lee CH, Raines KW, Ren K, Williamson LN, Conner DP

Publikováno v: The AAPS journal [AAPS J] 2012 Mar; Vol. 14 (1), pp. 19-22. Date of Electronic Publication: 2011 Dec 01.

Quantitative gas chromatography/time-of-flight mass spectrometry: a review.

Autor: Williamson LN; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602-2352, USA., Bartlett MG

Publikováno v: Biomedical chromatography : BMC [Biomed Chromatogr] 2007 Jul; Vol. 21 (7), pp. 664-9.