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Publikováno v:
Journal of Chemical Technology and Biotechnology
BACKGROUND The loss of efficiency and performance of bioprocesses on scale‐up is well known, but not fully understood. This work addresses this problem, by studying the effect of some fermentation gradients (pH, glucose and oxygen) that occur at th
Publikováno v:
Journal of Chemical Technology & Biotechnology. 94:647-657
Scaled‐down models are small‐scale bioreactors, used to mimic the chemical (pH, nutrient and dissolved oxygen) and physical (pressure, viscosity and temperature) gradients known to occur in the large‐scale fermenter. Conventionally, before scal