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of 8
pro vyhledávání: '"Williams, Jamie J.L."'
Yes
Exaggerated Janus kinase-signal transducer and activator of transcription (JAKSTAT) signalling is key to the pathogenesis of pro-inflammatory disorders, such as rheumatoid arthritis and cardiovascular diseases. Mutational activation of JAKs
Exaggerated Janus kinase-signal transducer and activator of transcription (JAKSTAT) signalling is key to the pathogenesis of pro-inflammatory disorders, such as rheumatoid arthritis and cardiovascular diseases. Mutational activation of JAKs
Externí odkaz:
http://hdl.handle.net/10454/13522
Autor:
Williams, Jamie J.L., Alotaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G.S., Schaper, F., Pilch, P.F., Palmer, Timothy M.
Yes
Effective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is
Effective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is
Externí odkaz:
http://hdl.handle.net/10454/14661
Autor:
Rutherford, C., Speirs, C., Williams, Jamie J.L., Ewart, M-A., Mancini, S.J., Hawley, S.A., Delles, C., Viollet, B., Costa-Pereira, A.P., Baillie, G.S., Salt, I.P., Palmer, Timothy M.
Yes
AMP-activated protein kinase (AMPK) is a pivotal regulator of metabolism at the cellular and organismal levels. AMPK also suppresses inflammation. We found that pharmacological activation of AMPK rapidly inhibited the Janus kinase (JAK)–si
AMP-activated protein kinase (AMPK) is a pivotal regulator of metabolism at the cellular and organismal levels. AMPK also suppresses inflammation. We found that pharmacological activation of AMPK rapidly inhibited the Janus kinase (JAK)–si
Externí odkaz:
http://hdl.handle.net/10454/10881
Yes
Caveolae are curved lipid raft regions rich in cholesterol and sphingolipids found abundantly in vascular endothelial cells, adipocytes, smooth muscle cells, and fibroblasts. They are multifunctional organelles with roles in clathrin-indepen
Caveolae are curved lipid raft regions rich in cholesterol and sphingolipids found abundantly in vascular endothelial cells, adipocytes, smooth muscle cells, and fibroblasts. They are multifunctional organelles with roles in clathrin-indepen
Externí odkaz:
http://hdl.handle.net/10454/8042
Yes
The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic inte
The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic inte
Externí odkaz:
http://hdl.handle.net/10454/7925
Sexual dysfunction is a major, although poorly understood, side-effect of treatment with antipsychotic drugs. We have recently show marked disruption of reproductive function and weight gain in female rats treated subchronically with risperidone and
Externí odkaz:
http://hdl.handle.net/10454/4079
Autor:
Durham, Gillian A.1, Williams, Jamie J.L.2, Nasim, M. Talat1, Palmer, Timothy M.1,3 Tim.Palmer@hyms.ac.uk
Publikováno v:
Trends in Pharmacological Sciences. May2019, Vol. 40 Issue 5, p298-308. 11p.
Autor:
Speirs, Claire1, Williams, Jamie J.L.2, Riches, Kirsten3, Salt, Ian P.1, Palmer, Timothy M.2 T.Palmer1@bradford.ac.uk
Publikováno v:
Pharmacological Research. Feb2018, Vol. 128, p88-100. 13p.