Zobrazeno 1 - 10
of 218
pro vyhledávání: '"William Y. Kim"'
Autor:
Wolfgang Beckabir, Mi Zhou, Jin Seok Lee, Steven P. Vensko, Mark G. Woodcock, Hsing-Hui Wang, Sara E. Wobker, Gatphan Atassi, Alec D. Wilkinson, Kenneth Fowler, Leah M. Flick, Jeffrey S. Damrauer, Michael R. Harrison, Karen P. McKinnon, Tracy L. Rose, Matthew I. Milowsky, Jonathan S. Serody, William Y. Kim, Benjamin G. Vincent
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in combination with chemotherapy, have demonstrated promising pathologic response (
Externí odkaz:
https://doaj.org/article/20a284baf2454780aedd68c631ea83b7
Autor:
Christopher J. Ricketts, Aguirre A. De Cubas, Huihui Fan, Christof C. Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A. Gibb, Rehan Akbani, Rameen Beroukhim, Donald P. Bottaro, Toni K. Choueiri, Richard A. Gibbs, Andrew K. Godwin, Scott Haake, A. Ari Hakimi, Elizabeth P. Henske, James J. Hsieh, Thai H. Ho, Rupa S. Kanchi, Bhavani Krishnan, David J. Kwiatkowski, Wenbin Liu, Maria J. Merino, Gordon B. Mills, Jerome Myers, Michael L. Nickerson, Victor E. Reuter, Laura S. Schmidt, C. Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G. Vincent, Cathy D. Vocke, David A. Wheeler, Lixing Yang, William Y. Kim, A. Gordon Robertson, Paul T. Spellman, W. Kimryn Rathmell, W. Marston Linehan
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113063- (2024)
Externí odkaz:
https://doaj.org/article/53d6204d634d4e3487233c292d61e7e8
Autor:
Jeffrey S. Damrauer, Wolfgang Beckabir, Jeff Klomp, Mi Zhou, Elizabeth R. Plimack, Matthew D. Galsky, Petros Grivas, Noah M. Hahn, Peter H. O’Donnell, Gopa Iyer, David I. Quinn, Benjamin G. Vincent, Diane Zipursky Quale, Sara E. Wobker, Katherine A. Hoadley, William Y. Kim, Matthew I. Milowsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The Bladder Cancer Advocacy Network established the UC-GENOME study in order to create a biobank and data repository for metastatic urothelial carcinoma. Here, the authors present the first characterization and analysis of DNA and RNA sequencing data
Externí odkaz:
https://doaj.org/article/0bf19d5b29ef4d3b9204ad4bf88f3eed
Autor:
Kristin Weiss, Kathryn H. Gessner, Alysen Demzik, Elizabeth Moreton, William Y. Kim, Sara E. Wobker, Tracy L. Rose, Matthew I. Milowsky, Marc A. Bjurlin
Publikováno v:
Cancer Treatment and Research Communications, Vol 37, Iss , Pp 100779- (2023)
Bladder cancer researchers and clinicians have increasingly viewed tumor biology through the lens of genomic and molecular alterations, drastically improving our knowledge of the underlying disease biology. This understanding has led to significant a
Externí odkaz:
https://doaj.org/article/7ea9b8de377d4bed92732f6aa01ecd54
Autor:
Tiffany Tate, Tina Xiang, Sarah E. Wobker, Mi Zhou, Xiao Chen, Hyunwoo Kim, Ekatherina Batourina, Chyuan-Sheng Lin, William Y. Kim, Chao Lu, James M. Mckiernan, Cathy Lee Mendelsohn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
PPARg is differentially expressed in bladder cancer subtypes. Here, the authors show in mice that when an activated form of PPARg is expressed in basal bladder cells tumours do not form, however in the presence of injury the basal cells differentiate
Externí odkaz:
https://doaj.org/article/458eca01a6e54249ad6eb5780e7e2e46
Autor:
Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic ac
Externí odkaz:
https://doaj.org/article/b6df3eea370a40a0932a4398891238b5
Autor:
Christopher G. Wood, James E. Ferguson III, Joel S. Parker, Dominic T. Moore, Jennifer G. Whisenant, Susan J. Maygarden, Eric M. Wallen, William Y. Kim, Mathew I. Milowsky, Kathryn E. Beckermann, Nancy B. Davis, Scott M. Haake, Jose A. Karam, Dante S. Bortone, Benjamin G. Vincent, Thomas Powles, W. Kimryn Rathmell
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
BACKGROUND Surgery remains the frontline therapy for patients with localized clear cell renal cell carcinoma (ccRCC); however, 20%–40% recur. Angiogenesis inhibitors have improved survival in metastatic patients and may result in responses in the n
Externí odkaz:
https://doaj.org/article/514517eaefb4496c854f9e31607be03d
Autor:
Sean T. Bailey, Aleisha M. Smith, Jordan Kardos, Sara E. Wobker, Harper L. Wilson, Bhavani Krishnan, Ryoichi Saito, Hyo Jin Lee, Jing Zhang, Samuel C. Eaton, Lindsay A. Williams, Ujjawal Manocha, Dorien J. Peters, Xinchao Pan, Thomas J. Carroll, Dean W. Felsher, Vonn Walter, Qing Zhang, Joel S. Parker, Jen Jen Yeh, Richard A. Moffitt, Janet Y. Leung, William Y. Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl a
Externí odkaz:
https://doaj.org/article/0f0c33aaa830403a92bded52b464aea5
Autor:
Michal Safran, William Y. Kim, Andrew L. Kung, James W. Horner, Ron A. DePinho, William G. Kaelin
Publikováno v:
Molecular Imaging, Vol 2 (2003)
Conditional alleles containing LoxP recombination sites, in conjunction with Cre recombinase delivered by a variety of means, allows for spatial and temporal control of gene expression in mouse models. Here we describe a mouse strain in which a lucif
Externí odkaz:
https://doaj.org/article/dbe6f2f367864f1e9dc51d510c172587
Publikováno v:
American journal of physiology. Cell physiology. 323(5)
In clear cell renal cell carcinoma (ccRCC), the von Hippel–Lindau tumor suppressor gene/hypoxia inducible factor (VHL/HIF) axis lays the groundwork for tumorigenesis and is the target of many therapeutic agents. HIF activation alone, however, is la