Zobrazeno 1 - 10
of 57
pro vyhledávání: '"William Y. Chang"'
Autor:
James T. Parker, Ching-Yun Chang, Kara Kersjes, Ixavier A. Higgins, Andrew C. Vendel, William Y. Chang
Publikováno v:
Biology, Vol 13, Iss 10, p 778 (2024)
Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease which can present with mixed organ involvement. Kidney involvement in lupus nephritis (LN) is a severe complication and major cause of mortality in SLE patients, second only
Externí odkaz:
https://doaj.org/article/1ee18fd0b84c40ea90bbb3805ea37749
Autor:
Jeffrey S. Boyles, Dorota Sadowski, Scott Potter, Aleksandra Vukojicic, James Parker, William Y. Chang, Yanfei L. Ma, Mark G. Chambers, James Nelson, Barbra Barmettler, Eric M. Smith, Kara Kersjes, Evan R. Himes, Chaohua Lin, Jonathan Lucchesi, Jaladhi Brahmbhatt, Ramtin Sina, Jennifer A. Martin, Evan Maestri, Christopher M. Wiethoff, Gregory L. Dyas, Matthew D. Linnik, Songqing Na, Derrick R. Witcher, Alison Budelsky, Kira Rubtsova
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
B cells contribute to multiple aspects of autoimmune disorders, and B cell–targeting therapies, including B cell depletion, have been proven to be efficacious in treatment of multiple autoimmune diseases. However, the development of novel therapies
Externí odkaz:
https://doaj.org/article/71aa2cc4be704328879505e403536058
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312
https://pubmed.ncbi.nlm.nih.gov/33852312
Autor:
William Y. Chang, Shad M. Reese
Publikováno v:
Unmanned Systems Technology XIX.
The Office of the Under Secretary of Defense (OUSD) for Acquisition, Technology, and Logistics (ATandL) Joint Ground Robotics Enterprise (JGRE) and the Office of the Assistant Secretary of Defense for Research and Engineering (OASD RandE) support a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca8edc10b337806efcd9af16ac08acb6
https://doi.org/10.1117/12.2264478
https://doi.org/10.1117/12.2264478
Autor:
Kaiguo Mo, Amit H. Shah, Peter Vollmayr, Gareth Lewis, Shannon M. Fernando, Lee Niel, D. Ashley Monks, William Y. Chang, Diptendu Chatterjee, Jeffrey N. Miner, Jon Rosen, Mei Hua Hong
Publikováno v:
Endocrinology. 150:3207-3213
The spinal nucleus of the bulbocavernosus (SNB) neuromuscular system is a highly conserved and well-studied model of sexual differentiation of the vertebrate nervous system. Sexual differentiation of the SNB is currently thought to be mediated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d065b1704e66e20b1b980431227240d
https://doi.org/10.1210/en.2008-1478
https://doi.org/10.1210/en.2008-1478
Autor:
Aimee Hogue, Eric G. Vajda, Francisco J. López, Dale E. Mais, Kelven Burnett, Keith B. Marschke, Lin Zhi, Arjan van Oeveren, Bijan Pedram, Yixing Shen, Yanling Chen, William Y. Chang, Kimberly N Griffiths, Martin D. Meglasson
Publikováno v:
Journal of Bone and Mineral Research. 24:231-240
Recent clinical trials with bisphosphonates and PTH have not supported the hypothesis that combination treatments with antiresorptive and anabolic agents would lead to synergistic activity. We hypothesized that combination treatment with a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11520d3ccf194ce9a6e25dafa0fe1f01
https://doi.org/10.1359/jbmr.081007
https://doi.org/10.1359/jbmr.081007
Autor:
Eric G. Vajda, Rob Hill, Kyoung-Jin Lee, Francisco J. López, Martin D. Meglasson, Yong-Hee Lee, William Y. Chang, Zhihong O'Brien, Yanling Chen, Peter J. Rix
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:663-670
Selective androgen receptor modulators (SARMs) are a new class of molecules in development to treat a variety of diseases. SARMs maintain the beneficial effects of androgens, including increased muscle mass and bone density, while having reduced acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e46cdbf91aa764f39e0d32fc2be531
https://doi.org/10.1124/jpet.108.146811
https://doi.org/10.1124/jpet.108.146811
Autor:
Esther Martinborough, Donald S. Karanewsky, Francisco J. López, Robert I. Higuchi, Min Wu, William Y. Chang, Marquis L. Cummings, Lin Zhi, Thomas Lau, Yun Oliver Long, Thomas R. Caferro, Keith B. Marschke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2967-2971
Modification on a lead series of [1,4]oxazino[3,2-g]quinolin-7-ones at the 2-position led to selective androgen receptor modulators with improved in vivo activity. The most potent analog (-)-33a exhibited full maintenance of levator ani muscle at 3mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552333f5b43ce9586e4d20f15f4bb123
https://doi.org/10.1016/j.bmcl.2008.03.062
https://doi.org/10.1016/j.bmcl.2008.03.062
Autor:
Jeffrey N. Miner, Mei Hua Hong, William Y. Chang, Junlian Hu, Jon Rosen, Kelven Burnett, Andres Negro-Vilar, Hong Sun, Cheng He Jin, Mark S. Chapman
Publikováno v:
Endocrinology. 149:1103-1112
Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb08bd5061462422ee76132f47ce8554
https://doi.org/10.1210/en.2007-0530
https://doi.org/10.1210/en.2007-0530
Autor:
M. Benjamin Hock, Josep A. Villena, Vincent Giguère, Joanalyn E. Barcas, William Y. Chang, Anastasia Kralli
Publikováno v:
Proceedings of the National Academy of Sciences. 104:1418-1423
Survival of organisms requires the ability to adapt to changes in the environment. Adaptation of oxidative metabolism is essential for meeting increased energy demands in response to stressors, such as exposure to cold temperatures or increased physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31221ad11a6b63ac2198c3dea17efa68
https://doi.org/10.1073/pnas.0607696104
https://doi.org/10.1073/pnas.0607696104