Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William Wei-Guo Jia"'
Autor:
Dmitry V. Chouljenko, Yanal M. Murad, I-Fang Lee, Zahid Delwar, Jun Ding, Guoyu Liu, Xiaohu Liu, Xuexian Bu, Yi Sun, Ismael Samudio, William Wei-Guo Jia
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 334-348 (2023)
VG2025 is a recombinant oncolytic herpes simplex virus type 1 (HSV-1) that uses transcriptional and translational dual regulation (TTDR) of critical viral genes to enhance virus safety and promote tumor-specific virus replication without reducing vir
Externí odkaz:
https://doaj.org/article/e9417876f2114e71ae5406c354d90859
Autor:
Zahid Delwar, Olga Tatsiy, Dmitry V. Chouljenko, I-Fang Lee, Guoyu Liu, Xiaohu Liu, Luke Bu, Jun Ding, Manu Singh, Yanal M. Murad, William Wei-Guo Jia
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1805 (2023)
The development of effective cancer vaccines remains a significant challenge due to immune tolerance and limited clinical benefits. Oncolytic herpes simplex virus type 1 (oHSV-1) has shown promise as a cancer therapy, but efficacy is often limited in
Externí odkaz:
https://doaj.org/article/2b25db2b41954448a600579c966045a4
Autor:
Jun Ding, Yanal M. Murad, Yi Sun, I-Fang Lee, Ismael Samudio, Xiaohu Liu, William Wei-Guo Jia, Ronghua Zhao
Publikováno v:
Viruses, Vol 14, Iss 11, p 2327 (2022)
Oncolytic viruses (OVs) can specifically replicate in the host and cause cancer cell lysis while inducing an antitumor immune response. The aim of this study is to investigate the impact of either pre-existing immunity against herpes simplex virus ty
Externí odkaz:
https://doaj.org/article/58728e3a09274eeca422345465fa6c2d
Autor:
Dmitry V. Chouljenko, Jun Ding, I-Fang Lee, Yanal M. Murad, Xuexian Bu, Guoyu Liu, Zahid Delwar, Yi Sun, Sheng Yu, Ismael Samudio, Ronghua Zhao, William Wei-Guo Jia
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 484 (2020)
Oncolytic virotherapy is a promising new tool for cancer treatment, but direct lytic destruction of tumor cells is not sufficient and must be accompanied by strong immune activation to elicit anti-tumor immunity. We report here the creation of a nove
Externí odkaz:
https://doaj.org/article/a6d8ed029b5444409dd42fce8acb87b6
Autor:
Yanal M. Murad, I-Fang Lee, Xiaohu Liu, Zahid Delwar, Jun Ding, Guoyu Liu, Olga Tatsiy, Dmitry Chouljenko, Gregory Hussack, Henk Van Faassen, William Wei-Guo Jia
VG21306 is a novel oncolytic virus (OV) that encodes a secretable bispecific T-cell engager targeting Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6)-expressing tumors. Delivering a T-cell engager locally to a tumor mass will circumvent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c37ea6bc212e0c49a9651812dc954196
https://doi.org/10.1101/2023.01.02.522257
https://doi.org/10.1101/2023.01.02.522257
Publikováno v:
Journal of Molecular Biology. 358:38-45
Adeno-associated virus (AAV) is a non-pathogenic virus and the only known eukaryotic virus capable of targeting human chromosome 19 for integration at a well-characterized AAVS1 site. Its site-specific integration is mediated by Rep68 and Rep78, vira
Publikováno v:
Developmental Brain Research. 85:109-118
Ligand-stimulated phosphoinositide hydrolysis activates a bifurcating second messenger system, releasing inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DG), which activates protein kinase C (PKC). Yet, in developing cat visual cortex and hipp