Zobrazeno 1 - 10
of 37
pro vyhledávání: '"William W.-C. Chan"'
Autor:
William W.-C. Chan, Colin R. Phillips
Publikováno v:
Indoor Air Pollution ISBN: 9781003210566
Indoor Air Pollution
Indoor Air Pollution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05021f597a454869f77e3373df081d57
https://doi.org/10.1201/9781003210566-15
https://doi.org/10.1201/9781003210566-15
Publikováno v:
Biochemical Journal. 320:17-26
The concurrent effects of two enzyme inhibitors have been analysed previously with the Yonetani-Theorell plot to obtain insight into the interactions between bound inhibitors. This procedure, like many other traditional graphical methods in enzymolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff57189cd911c69f14e50b42da8c2870
https://doi.org/10.1042/bj3200017
https://doi.org/10.1042/bj3200017
Publikováno v:
FEBS Letters. 260:206-208
A tetrahedral intermediate is the prominent feature of the generally accepted mechanism for aspartate transcarbamoylase. We have synthesized N-pyrophosphoryl-L-aspartate as a charged analogue of the postulated intermediate. Surprisingly, its affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf49bd6938c0d4b0a8043e34b7a98b2c
https://doi.org/10.1016/0014-5793(90)80104-q
https://doi.org/10.1016/0014-5793(90)80104-q
Autor:
Daniel S.C. Yang, Ernest Asante-Appiah, William W.-C. Chan, Frank Sicheri, Jayaraman Seetharaman
Publikováno v:
Biochemistry. 36(29)
gem-Dimethylsuccinic acid and its higher homolog, 2-methyl-2-ethylsuccinic acid (MESA) are highly potent inhibitors of both carboxypeptidase A (CPA) and B. The inhibition constant of MESA for CPA (0.11 microM for the racemic mixture) is remarkable co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f70eaa9306c6ac9db5c533416ae905
https://pubmed.ncbi.nlm.nih.gov/9220957
https://pubmed.ncbi.nlm.nih.gov/9220957
Publikováno v:
The Biochemical journal. 315
Inhibition of the protease in HIV is a potentially useful approach for the treatment of AIDS. In the course of evaluating inhibitors of the HIV-1 protease, we observed a strong synergism between certain inhibitors that might be expected to bind to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc95df37670ddff0672c861609b306bc
https://pubmed.ncbi.nlm.nih.gov/8670094
https://pubmed.ncbi.nlm.nih.gov/8670094
Publikováno v:
European journal of biochemistry. 218(2)
The observation of binding synergism has been successfully extended to include carboxypeptidases A and B. The behaviour of these two enzymes follows the same pattern previously found for three other Zn-proteases. Thus in all cases examined, the affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8863ae8f382c3c31b6e126b3ae18c6d7
https://pubmed.ncbi.nlm.nih.gov/8269943
https://pubmed.ncbi.nlm.nih.gov/8269943
Publikováno v:
European journal of biochemistry. 218(2)
The strong synergism previously observed in the binding of inhibitors to two Zn-proteases, has also been found for thermolysin. As in earlier cases, the effects are produced by a small Zn-ligand (e.g. a hydroxamate) in the presence of another compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c5d852beed8cbacced26c680127142
https://pubmed.ncbi.nlm.nih.gov/8269942
https://pubmed.ncbi.nlm.nih.gov/8269942
Autor:
William W.-C. Chan, Caroline A. Enns
Publikováno v:
Journal of Biological Chemistry. 254:6180-6186
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c38ee7c8a4ad7e017b4f796e8a60e11
https://doi.org/10.1016/s0021-9258(18)50535-4
https://doi.org/10.1016/s0021-9258(18)50535-4
Publikováno v:
Analytical Biochemistry. 145:331-338
A rapid and convenient assay for ribonucleotide reductase has been developed in which the reaction product, deoxycytidine diphosphate (dCDP), is isolated without further conversion. The enzymatic reaction is terminated by the addition of ethanol and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118dd5278903e1003ee4ec7fc343ae0f
https://doi.org/10.1016/0003-2697(85)90370-7
https://doi.org/10.1016/0003-2697(85)90370-7
Autor:
William W.-C. Chan, Caroline A. Enns
Publikováno v:
Canadian Journal of Biochemistry. 56:654-658
Aspartate transcarbamoylase from Escherichia coli is composed of six catalytic (c) and six regulatory (r) polypeptides. We have studied the structure and function of this enzyme using chymotrypsin as a probe. The protease inactivates the isolated cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c12b2a93362652d169c858688bcae7
https://doi.org/10.1139/o78-098
https://doi.org/10.1139/o78-098