Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex

Autor: Connor Johnson, Lisa N. Kretsge, William W. Yen, Balaji Sriram, Alexandra O’Connor, Ruichen Sky Liu, Jessica C. Jimenez, Rhushikesh A. Phadke, Kelly K. Wingfield, Charlotte Yeung, Tushare J. Jinadasa, Thanh P. H. Nguyen, Eun Seon Cho, Erelle Fuchs, Eli D. Spevack, Berta Escude Velasco, Frances S. Hausmann, Luke A. Fournier, Alison Brack, Sarah Melzer, Alberto Cruz-Martín

Publikováno v: Molecular psychiatry. 27(5)

A hallmark of the anterior cingulate cortex (ACC) is its functional heterogeneity. Functional and imaging studies revealed its importance in the encoding of anxiety-related and social stimuli, but it is unknown how microcircuits within the ACC encode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1da4488df6f54999dac7762a54df2d
https://pubmed.ncbi.nlm.nih.gov/35246635

Distinct VIP interneurons in the cingulate cortex encode anxiogenic and social stimuli

Autor: William W. Yen, Tushare Jinadasa, Alexandra O’Connor, Lisa N. Kretsge, Eli D. Spevack, Ruichen Sky Liu, Berta Escude Velasco, Erelle Fuchs, Connor Johnson, Eun Seon Cho, Alberto Cruz-Martín, Jessica C. Jimenez, Thanh P. H. Nguyen, Frances S. Hausmann, Balaji Sriram

A hallmark of higher-order cortical regions is their functional heterogeneity, but it is not well understood how these areas encode such diverse information. The anterior cingulate cortex (ACC), for example, is important in both emotional regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8590c483ae0a401fe8387caa0146e0bd
https://doi.org/10.1101/2020.12.22.424056

Sex Differences in Behavioral and Brainstem Transcriptomic Neuroadaptations following Neonatal Opioid Exposure in Outbred Mice

Autor: Camron D. Bryant, Alberto Cruz-Martín, Jacob C. Beierle, Qiu T Ruan, Kristyn N. Borrelli, Elisha M. Wachman, Julia L. Scotellaro, William Evan Johnson, Emily J Yao, William W. Yen, Ryan W. Logan, Julia C Kelliher, Rhushikesh A. Phadke, Carly R. Langan, Melanie M Chen, Richard K Babbs

Publikováno v: eNeuro

The opioid epidemic led to an increase in the number of Neonatal Opioid Withdrawal Syndrome (NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of NOWS include weight loss, severe irritability, respiratory problems, and sleep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785550b1919de4192e3012169ecbf77e
https://doi.org/10.1523/eneuro.0143-21.2021

Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

Autor: Frances S. Hausmann, Kevin Liu Kot, Lisa N. Kretsge, SaraAnn Rosenthal, Rhushikesh A. Phadke, Yenyu Liu, Balaji Sriram, Alberto Cruz-Martín, Tushare Jinadasa, Giovanna Antognetti, Borislav Dejanovic, Elena R. Newmark, James Gilbert, Jungjoon Lee, Ashley L. Comer, William W. Yen, Thanh P. H. Nguyen

Publikováno v: PLoS Biology, Vol 18, Iss 1, p e3000604 (2020)
PLoS Biology

Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia; however, it is not known whether C4 plays a causative role in this br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ecfbf96b80462153034d12ec0c4f09
https://doi.org/10.1371/journal.pbio.3000604

Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment.

Autor: Stewart DC; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brisson BK; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dekky B; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Berger AC; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Yen W; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mauldin EA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Loebel C; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.; Department of Materials Science & Engineering, University of Michigan, Ann Arbor, MI, USA., Gillette D; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Assenmacher CA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Quincey C; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stefanovski D; Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA., Cristofanilli M; Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Cukierman E; Cancer Signaling and Microenvironment Program, The Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Burdick JA; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.; BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA., Borges VF; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; University of Colorado Cancer Center, Aurora, CO, USA.; Young Women's Breast Cancer Translational Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Volk SW; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. swvolk@vet.upenn.edu.

Publikováno v: NPJ breast cancer [NPJ Breast Cancer] 2024 Oct 02; Vol. 10 (1), pp. 86. Date of Electronic Publication: 2024 Oct 02.