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of 167
pro vyhledávání: '"William W. Wright"'
Autor:
William W. Wright
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
This review focuses on the in vivo regulation of spermatogonial stem cells (SSCs) in adult testes by glial cell line-derived neurotrophic factor (GDNF). To study adult mouse testes, we reversibly inhibited GDNF stimulation of SSCs via a chemical-gene
Externí odkaz:
https://doaj.org/article/dc0e87432232486e9bb655d9af064637
Autor:
Chenglai Fu, Tomas Rojas, Alfred C. Chin, Weiwei Cheng, Isaac A. Bernstein, Lauren K. Albacarys, William W. Wright, Solomon H. Snyder
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development. This development requires
Externí odkaz:
https://doaj.org/article/f739f70dc2034291be1474b5f19655c4
Autor:
Kyle E. Orwig, Jon M. Oatley, Kevan M. Shokat, Andrew Laychur, Florentine U. Rutaganira, William W. Wright, Nicole Parker, Chao Zhang, Meena Sukwani
Publikováno v:
Stem Cell Reports
Summary One cause of human male infertility is a scarcity of spermatogonial stem cells (SSCs) in testes with Sertoli cells that neither produce adequate amounts of GDNF nor form the Sertoli-Sertoli junctions that form the blood-testis barrier (BTB).
Autor:
Michael D. Griswold, John R. McCarrey, Wei Yan, Marie-Claire Orgebin-Crist, William W. Wright, Erwin Goldberg, Bernard Robaire, Mitch Eddy, Leslie L. Heckert, Vassilios Papadopoulos, Jacquetta M. Trasler, Barry R. Zirkin
Publikováno v:
AndrologyREFERENCES. 8(4)
OBJECTIVE To provide an overview of the history of the North American Testis Workshop (NATW), of its relationship to the American Society of Andrology (ASA), and of the publications that resulted from the first 25 workshops. METHODS The collection of
Autor:
Tomas Rojas, Alfred C. Chin, Chenglai Fu, Lauren K. Albacarys, Isaac A. Bernstein, William W. Wright, Solomon H. Snyder, Weiwei Cheng
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development. This development requires selective
Autor:
Peter N. Schlegel, William W. Wright, Darius A. Paduch, Dileep Singh, Alexander Bolyakov, Anna Mielnik, Kyle E. Orwig
Publikováno v:
Human Reproduction. 32:1108-1117
Study question Do human Sertoli cells in testes that exhibit the Sertoli cell-only (SCO) phenotype produce substantially less glial cell line-derived neurotrophic factor (GDNF) than Sertoli cells in normal testes? Summary answer In human SCO testes,
Autor:
Peter N. Schlegel, William W. Wright, Anne E. Jedlicka, Stephanie Hilz, Darius A. Paduch, Andrew Grimson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216586 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216586 (2019)
Sertoli cell-only (SCO) syndrome is a severe form of human male infertility seemingly characterized by the lack all spermatogenic cells. However, tubules of some SCO testes contain small patches of active spermatogenesis and thus spermatogonial stem
Autor:
Dolly Singh, William W. Wright, Janet Folmer, Kevan M. Shokat, Joseph M. Savitt, Liang Chin Chen, Chao Zhang
Publikováno v:
Stem Cells. 30:732-740
Maintaining adequate numbers of spermatogonial stem cells is required for the production of the millions of sperm required for male fertility. To date, however, the mechanisms that regulate the size of this pool in the adult are poorly defined. Glial
Autor:
Barry R. Zirkin, Haolin Chen, William W. Wright, Alissa Renne, Marlin D. Friesen, Jonathan P. Jarow, Lindi Luo, Terry R. Brown
Publikováno v:
Journal of Andrology. 33:691-698
An isotope dilution mass spectrometry method has been developed for the simultaneous measurement of picolinoyl derivatives of testosterone (T), dihydrotestosterone (DHT), 17β-estradiol (E(2)), and 5α-androstan-3α,17β-diol (3α-diol) in rat intrat
Publikováno v:
Biology of Reproduction. 85:763-769
In the adult testis, the precise control of the self-renewing replication and differentiation of stem spermatogonia is fundamental to male fertility. Previous studies have shown that the replication of A single (As) spermatogonia, a population that i