Zobrazeno 1 - 10
of 139
pro vyhledávání: '"William W. Morgan"'
Publikováno v:
Experimental Neurology. 229:421-428
This study investigated the effect of a knockout of the caspase 2 gene on the sensitivity of murine nigral dopaminergic neurons to 1-methyl-4-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity. Female wild type (WT), heterozygous caspase 2 NL (HET) a
Autor:
James L. Roberts, William W. Morgan, Guiming Li, K.C. Biju, Syed Z Imam, Robert A. Clark, Senlin Li, Qing Zhou
Publikováno v:
Molecular Therapy. 18:1536-1544
Glial cell line-derived neurotrophic factor (GDNF) has emerged as the most potent neuroprotective agent tested in experimental models for the treatment of Parkinson's disease (PD). However, its use is hindered by difficulties in delivery to the brain
Autor:
Charles Keller, Osamu Togao, Aislynn K. Samano, Ai-Ling Lin, Timothy Q. Duong, Laura D. Nelon, William W. Morgan, Aoife Kilcoyne, Inkyung Jung, Brent M. Nowak, Thomas G. Whitney, Suresh I. Prajapati, Brian P. Rubin, Eri Taniguchi, Sachiko Ohshima-Hosoyama
Publikováno v:
Transgenic Research. 19:829-840
Medulloblastoma is an aggressive childhood cerebellar tumor. We recently reported a mouse model with conditional deletion of Patched1 gene that recapitulates many characteristics of the human medulloblastoma. Qualitative symptoms observed in the mous
Publikováno v:
Journal of Neurochemistry. 76:825-834
It has been known for nearly 30 years that glucocorticoid receptor stimulation induces increased tyrosine hydroxylase (TH) gene expression. However, the mechanism mediating this effect has remained elusive. Sequences with homology to known glucocorti
Autor:
Linda Y Johnson, William W. Morgan, Chatchai Trakulrungsi, Mary K. Vaughan, Bruce Richardson, Wantanee K. Trakulrungsi, Russel J. Reiter, Jerry Vriend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::866ca1c398d9d2e123b2b062e71d4579
https://doi.org/10.1159/000406508
https://doi.org/10.1159/000406508
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 58:B394-B399
To determine whether reduced caloric intake affects the susceptibility of nigrostriatal dopamine (DA) neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, 1-year-old male C57BL6 mice were offered food ad libitum or we
Autor:
Randy Strong, Kelly Lynch, Shou Shu Wang, William W. Morgan, Elizabeth Fernandez, Timothy Hagerty
Publikováno v:
Journal of Neurochemistry. 78:1379-1388
The purpose of the work reported here was to determine whether the tyrosine hydroxylase glucocorticoid-responsive element (TH-GRE) interacts with the cyclic AMP pathway and the CRE in regulating mouse TH promoter activity, and whether an additional,
Autor:
Ahmad R. Heydari, William W. Morgan, Arlan Richardson, Christi A. Walter, James F. Nelson, Z. David Sharp
Publikováno v:
ILAR Journal. 38:124-136
Mitochondrial dysfunctions have been associated with neuronal apoptosis and are characteristic of neurodegenerative conditions. Caspases play a central role in apoptosis; however, their involvement in mitochondrial dysfunction-induced neuronal apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c1cc156f537b9c29aa8cb5c0bbaf1b
https://europepmc.org/articles/PMC3048733/
https://europepmc.org/articles/PMC3048733/