Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice[S]

Autor: Ryan S. Lim, Adelheid Kratzer, Nicholas P. Barry, Shinobu Miyazaki-Anzai, Makoto Miyazaki, William W. Mantulin, Moshe Levi, Eric O. Potma, Bruce J. Tromberg

Publikováno v: Journal of Lipid Research, Vol 51, Iss 7, Pp 1729-1737 (2010)

We characterized several cellular and structural features of early stage Type II/III atherosclerotic plaques in an established model of atherosclerosis—the ApoE-deficient mouse—by using a multimodal, coregistered imaging system that integrates th

Externí odkaz: https://doaj.org/article/34dff783e53c463da93d61042bc70185

Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients

Autor: Lingzhong Meng, William W. Mantulin, Brenton Alexander, Zeev N. Kain, Zhaoxia Yu, Maxime Cannesson, Bruce J. Tromberg, Albert E. Cerussi

Publikováno v: Meng, L; Cannesson, M; Alexander, BS; Yu, Z; Kain, ZN; Cerussi, AE; et al.(2011). Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients. British Journal of Anaesthesia, 107(2), 209-217. doi: 10.1093/bja/aer150. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/70g76459
Tromberg, BJ; Meng, L; Cannesson, M; Alexander, BS; Yu, Z; Kain, ZN; et al.(2011). Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients. Br J Anaesth, 107(2). UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/00h4q8ng
Meng, L; Cannesson, M; Alexander, B S; Yu, Z; Kain, Z N; Cerussi, A E; et al.(2011). Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients.. British journal of anaesthesia, 107(2), 209-217. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/9bd245fx

† Phenylephrine, but not ephedrine, decreased cardiac output (CO) and brain oxygenation. † This study highlights the importance of CO in preserving brain oxygenation during management of intraoperative hypotension. Background. How phenylephrine a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b023df77e5bef15f4139a619e7516b
https://doi.org/10.1093/bja/aer150

Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry

Autor: Enrico Gratton, Ursula Wolf, Sherri Hull, William W. Mantulin, Martin Wolf, Jee Hyun Choi, Daniel Coussirat, Antonios Michalos, L. Adelina Paunescu, Moshe Levi, Larisa P. Safonova, Devasmita Choudhury

Publikováno v: Wolf, U; Wolf, M; Choi, JH; Levi, M; Choudhury, D; Hull, S; et al.(2003). Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry.. Journal of vascular surgery, 37(5), 1017-1026. doi: 10.1067/mva.2003.214. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/32v8m029

PURPOSE: Near-infrared spectrophotometry is used to measure flow, concentration, and oxygenation of hemoglobin in arterioles, capillaries, and venules several centimeters deep in tissue. The purpose of this study was to investigate the distribution o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68608331ad6df0bae089a50b4220601b
https://doi.org/10.1067/mva.2003.214

Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment

Autor: Brian Hill, Darren Roblyer, Hosain Haghany, Albert E. Cerussi, William W. Mantulin, Samuel T. Keene, Robert V. Warren, Amanda Durkin, A Leproux, Thomas D. O'Sullivan, Bruce J. Tromberg

Publikováno v: Keene, ST; Cerussi, AE; Warren, RV; Hill, B; Roblyer, D; Leproux, A; et al.(2013). Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment. Progress in Biomedical Optics and Imaging-Proceedings of SPIE, 8578. doi: 10.1117/12.2008009. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9pp911zb

Instrument equivalence and quality control are critical elements of multi-center clinical trials. We currently have five identical Diffuse Optical Spectroscopic Imaging (DOSI) instruments enrolled in the American College of Radiology Imaging Network

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf10a89b0e7e0d6501cd28ce27ecba5a
https://doi.org/10.1117/12.2008009

Deep tissue fluorescence imaging and in vivo biological applications

Autor: Alexander Dvornikov, Enrico Gratton, Viera Crosignani, Chiara Stringari, Jose S. Aguilar, Robert Edwards, William W. Mantulin

Publikováno v: Journal of biomedical optics. 17(11)

We describe a novel technical approach with enhanced fluorescence detection capabilities in two-photon microscopy that achieves deep tissue imaging, while maintaining micron resolution. Compared to conventional two-photon microscopy, greater imaging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a173dbfc5a677aa825ff2cfda91ba5
https://pubmed.ncbi.nlm.nih.gov/23214184