Zobrazeno 1 - 10
of 11
pro vyhledávání: '"William W. Bullen"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:1399-1413
A liquid chromatographic/mass spectrometric (LC/MS/MS) method to quantitate CI-1011 in rat plasma has been validated and compared to an LC/UV assay. The analyte and internal standard were isolated from the plasma matrix by using liquid/liquid extract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697a605e8cbcba8fd107ac87e2459dbc
https://doi.org/10.1016/s0731-7085(98)00034-x
https://doi.org/10.1016/s0731-7085(98)00034-x
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 16(1)
CI-1010, a 2-nitroimidazole, is a chiral prodrug for the active moiety PD 146923 and is under development as an alkylating radiosensitizer to be used as an adjuvant to radiotherapy. Because CI-1010 has an estimated half-lifeor = 2 min under physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e080d0945e79662652cd6714f58499
https://pubmed.ncbi.nlm.nih.gov/9447551
https://pubmed.ncbi.nlm.nih.gov/9447551
Publikováno v:
Journal of chromatography. B, Biomedical applications. 668(1)
CI-980, a 1-deaza-7,8-dihydropteridine, is a novel anticancer agent that is a potent mitotic inhibitor acting as a tubulin binder similar to the vinca alkaloids. CI-980 has shown equivalent or superior anticancer activity in vitro compared to vincris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe090a731a0172bfba1417b77516bc15
https://pubmed.ncbi.nlm.nih.gov/7550971
https://pubmed.ncbi.nlm.nih.gov/7550971
Autor:
Robert A. Newman, Tsun Chang, Lloyd R. Whitfield, Larry D. Andress, William W. Bullen, Mattea Welch
Publikováno v:
Cancer chemotherapy and pharmacology. 30(3)
CI-973 is a new platinum compound with antitumor properties that is currently undergoing phase II clinical trials. A high-performance liquid chromatographic (HPLC) assay was developed and validated for ultrafiltrates of human plasma and urine to supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c111d837ef6c93db599fb3f12d04c2
https://pubmed.ncbi.nlm.nih.gov/1628368
https://pubmed.ncbi.nlm.nih.gov/1628368
Publikováno v:
Journal of chromatography. 526(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7a1eb27ac894bbcefbf0243abad275
https://pubmed.ncbi.nlm.nih.gov/2140367
https://pubmed.ncbi.nlm.nih.gov/2140367
Autor:
William W. Bullen, Edward R.B. McCabe, Stephen I. Goodman, Gary M. Lum, Manuel Roig, Steven P. Ringel, Mary Anne Guggenheim
Publikováno v:
Annals of Neurology. 7:441-449
Two brothers with a recently described inborn error of metabolism characterized by glyceroluria, hyperglycerolemia, and generalized glycerol kinase deficiency had moderate psychomotor retardation, spasticity, growth failure, a nonspecific myopathy, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6fafe4df296bef32ea55bf1a1fc5ff
https://doi.org/10.1002/ana.410070509
https://doi.org/10.1002/ana.410070509
Publikováno v:
Biochemical Medicine. 21:182-189
Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230d4b73aa16b7adc6a772d3af1dd664
https://doi.org/10.1016/0006-2944(79)90070-x
https://doi.org/10.1016/0006-2944(79)90070-x
Publikováno v:
Journal of the American Society for Mass Spectrometry. (1):55-66
A liquid chromatographic/mass spectrometric method to quantitate atorvastatin (AT) and its active metabolites ortho-hydroxy (o-AT) and para-hydroxy (p-AT) atorvastatin in human, dog, and rat plasma was validated. The method consisted of washing plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26636eb43b5e21402081bb1482f66364
Autor:
Mary Anne Guggenheim, Edward R.B. McCabe, Stephen I. Goodman, William W. Bullen, Donald J. Sceats, Paul V. Fennessey, Barbara S. Miles
Publikováno v:
Biochemical and biophysical research communications. 78(4)
Two brothers with a previously unidentified syndrome of severe osteoporosis and neuromuscular disease have elevated concentrations of glycerol in serum and urine. A deficiency of glycerol kinase in leukocytes of both patients is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22398ac1da65defc210d0e2da0e0e93e
https://pubmed.ncbi.nlm.nih.gov/200232
https://pubmed.ncbi.nlm.nih.gov/200232
Publikováno v:
Life sciences. 32(15)
Kinetic differences in the glycerol kinase activities from human liver and fibroblasts have been previously demonstrated by this laboratory. The present study was undertaken to characterize these enzymatic activities more completely. The pH profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2663bed7c862f9babe180da05fbecf29
https://pubmed.ncbi.nlm.nih.gov/6300598
https://pubmed.ncbi.nlm.nih.gov/6300598