Zobrazeno 1 - 10
of 12
pro vyhledávání: '"William W Hannon"'
Autor:
Iris Yousaf, William W Hannon, Ryan C Donohue, Christian K Pfaller, Kalpana Yadav, Ryan J Dikdan, Sanjay Tyagi, Declan C Schroeder, Wun-Ju Shieh, Paul A Rota, Alison F Feder, Roberto Cattaneo
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011817 (2023)
It is increasingly appreciated that pathogens can spread as infectious units constituted by multiple, genetically diverse genomes, also called collective infectious units or genome collectives. However, genetic characterization of the spatial dynamic
Externí odkaz:
https://doaj.org/article/45dc155a609f44e6a3b8340c1ffbda95
Autor:
Tyler N Starr, Allison J Greaney, Cameron M Stewart, Alexandra C Walls, William W Hannon, David Veesler, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010951 (2022)
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on thes
Externí odkaz:
https://doaj.org/article/935a02fbd2d6495d8f961be0fd3e02fe
Autor:
Tyler N. Starr, Allison J. Greaney, William W. Hannon, Andrea N. Loes, Kevin Hauser, Josh R. Dillen, Elena Ferri, Ariana Ghez Farrell, Bernadeta Dadonaite, Matthew McCallum, Kenneth A. Matreyek, Davide Corti, David Veesler, Gyorgy Snell, Jesse D. Bloom
Publikováno v:
Science. 377:420-424
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-converting enzyme 2 (ACE2) receptor and recognition by antibodies
Autor:
Bernadeta Dadonaite, Katharine H D Crawford, Caelan E Radford, Ariana G Farrell, Timothy C Yu, William W Hannon, Panpan Zhou, Raiees Andrabi, Dennis R Burton, Lihong Liu, David D. Ho, Richard A. Neher, Jesse D Bloom
Publikováno v:
bioRxiv
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emerging mutations in the viral spike protein. Here we describe a new deep mutational scanning platform based on non-replicative pseudotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b9ff3a1fcade6fdf7b7b300eb18831
https://europepmc.org/articles/PMC9580381/
https://europepmc.org/articles/PMC9580381/
Autor:
Tyler N. Starr, Allison J. Greaney, Cameron M. Stewart, Alexandra C. Walls, William W. Hannon, David Veesler, Jesse D. Bloom
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc63a4f13a9cb46b1c8de7cfcad6e4b
https://doi.org/10.1101/2022.09.20.508745
https://doi.org/10.1101/2022.09.20.508745
Autor:
Timothy C. Yu, Zorian T. Thornton, William W. Hannon, William S. DeWitt, Caelan E. Radford, Frederick A. Matsen, Jesse D. Bloom
Publikováno v:
Virus Evolution. 8
A challenge in studying viral immune escape is determining how mutations combine to escape polyclonal antibodies, which can potentially target multiple distinct viral epitopes. Here we introduce a biophysical model of this process that partitions the
Autor:
Meng Zhou, Minjeong Ko, Anna C. Hoge, Kelsey Luu, Yuzhen Liu, Magdalena L. Russell, William W. Hannon, Zhenwei Zhang, Jian Carrot-Zhang, Rameen Beroukhim, Eliezer M. Van Allen, Atish D. Choudhury, Peter S. Nelson, Matthew L. Freedman, Mary-Ellen Taplin, Matthew Meyerson, Srinivas R. Viswanathan, Gavin Ha
Publikováno v:
JCI insight. 7(17)
The complex genomic landscape of prostate cancer evolves across disease states under therapeutic pressure directed toward inhibiting androgen receptor (AR) signaling. While significantly altered genes in prostate cancer have been extensively defined,
Autor:
Bernadeta Dadonaite, Katharine H.D. Crawford, Caelan E. Radford, Ariana G. Farrell, Timothy C. Yu, William W. Hannon, Panpan Zhou, Raiees Andrabi, Dennis R. Burton, Lihong Liu, David D. Ho, Helen Y. Chu, Richard A. Neher, Jesse D. Bloom
Publikováno v:
Cell. 186:1263-1278.e20
Autor:
William W. Hannon, Pavitra Roychoudhury, Hong Xie, Lasata Shrestha, Amin Addetia, Keith R. Jerome, Alexander L. Greninger, Jesse D. Bloom
Publikováno v:
bioRxiv
The long-term evolution of viruses is ultimately due to viral mutants that arise within infected individuals and transmit to other individuals. Here, we use deep sequencing to investigate the transmission of viral genetic variation among individuals
Autor:
Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, Manish Chandra Choudhary, Jonathan Z. Li, Adam S. Dingens, Amin Addetia, William W. Hannon
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Science (New York, N.y.)
Science
article-version (status) pre
article-version (number) 1
Science (New York, N.y.)
Science
Mapping antibody escape in SARS-CoV-2 Several antibodies are in use or under development as therapies to treat COVID-19. As new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge, it is important to predict whether they will