Zobrazeno 1 - 10
of 118
pro vyhledávání: '"William Valdar"'
Autor:
Sarah R. Leist, Alexandra Schäfer, Ellen L. Risemberg, Timothy A. Bell, Pablo Hock, Mark R. Zweigart, Colton L. Linnertz, Darla R. Miller, Ginger D. Shaw, Fernando Pardo Manuel de Villena, Martin T. Ferris, William Valdar, Ralph S. Baric
Publikováno v:
Virus Research, Vol 346, Iss , Pp 199399- (2024)
Coronaviruses have caused three severe epidemics since the start of the 21st century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater understanding of
Externí odkaz:
https://doaj.org/article/9074f31c58d94cd2b9333731d7209b3e
Autor:
Megan M. Knuth, Jing Xue, Marwa Elnagheeb, Raad Z. Gharaibeh, Sarah A. Schoenrock, Susan McRitchie, Cory Brouwer, Susan J. Sumner, Lisa Tarantino, William Valdar, R. Scott Rector, Jeremy M. Simon, Folami Ideraabdullah
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionEmerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed.MethodsHere, we leveraged our Collaborative Cross mouse
Externí odkaz:
https://doaj.org/article/8293d185b25b4bafb987226841c7403f
Autor:
Anna C. Salvador, M. Nazmul Huda, Danny Arends, Ahmed M. Elsaadi, C. Anthony Gacasan, Gudrun A. Brockmann, William Valdar, Brian J. Bennett, David W. Threadgill
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Background The gut microbiota is modulated by a combination of diet, host genetics, and sex effects. The magnitude of these effects and interactions among them is important to understanding inter-individual variability in gut microbiota. In
Externí odkaz:
https://doaj.org/article/b402e2ffdfaf458f8c7d6ff0c082a0a0
Autor:
Alexis Payton, Kyle R. Roell, Meghan E. Rebuli, William Valdar, Ilona Jaspers, Julia E. Rager
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Toxicology research has rapidly evolved, leveraging increasingly advanced technologies in high-throughput approaches to yield important information on toxicological mechanisms and health outcomes. Data produced through toxicology studies are conseque
Externí odkaz:
https://doaj.org/article/e4ab2b6ee0e0451f8ffd2c1e15380a53
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010184 (2022)
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an intermediate fo
Externí odkaz:
https://doaj.org/article/72d0915fdb7d445a88a4acb36baf78d9
Autor:
Gregory R. Keele, Jeremy W. Prokop, Hong He, Katie Holl, John Littrell, Aaron W. Deal, Yunjung Kim, Patrick B. Kyle, Esinam Attipoe, Ashley C. Johnson, Katie L. Uhl, Olivia L. Sirpilla, Seyedehameneh Jahanbakhsh, Melanie Robinson, Shawn Levy, William Valdar, Michael R. Garrett, Leah C. Solberg Woods
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Chronic kidney disease (CKD), which can ultimately progress to kidney failure, is influenced by genetics and the environment. Genes identified in human genome wide association studies (GWAS) explain only a small proportion of the heritable v
Externí odkaz:
https://doaj.org/article/6d41003b7a614d5f9d1574c3f69d76e1
Autor:
John R. Shorter, Paul L. Maurizio, Timothy A. Bell, Ginger D. Shaw, Darla R. Miller, Terry J. Gooch, Jason S. Spence, Leonard McMillan, William Valdar, Fernando Pardo-Manuel de Villena
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1613-1622 (2019)
Reproductive success in the eight founder strains of the Collaborative Cross (CC) was measured using a diallel-mating scheme. Over a 48-month period we generated 4,448 litters, and provided 24,782 weaned pups for use in 16 different published experim
Externí odkaz:
https://doaj.org/article/d884049865cd449cbbaf7eb98722d981
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1707-1727 (2019)
The Collaborative Cross (CC) is a mouse genetic reference population whose range of applications includes quantitative trait loci (QTL) mapping. The design of a CC QTL mapping study involves multiple decisions, including which and how many strains to
Externí odkaz:
https://doaj.org/article/a704cc196011406abb39484717513a6d
Autor:
Robert W. Corty, William Valdar
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3767-3782 (2018)
Standard QTL mapping procedures seek to identify genetic loci affecting the phenotypic mean while assuming that all individuals have the same residual variance. But when the residual variance differs systematically between groups, perhaps due to a ge
Externí odkaz:
https://doaj.org/article/61ac72267b8d46bbaa66c6bcdb6fd46e
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3783-3790 (2018)
We illustrate, through two case studies, that “mean-variance QTL mapping”—QTL mapping that models effects on the mean and the variance simultaneously—can discover QTL that traditional interval mapping cannot. Mean-variance QTL mapping is base
Externí odkaz:
https://doaj.org/article/4b0be1ab4a954a4491a7bb14fb3121fe