Výsledky vyhledávání - "William V Williams"

Regression of Breast Cancer Metastases Following Treatment with Irradiated SV-BR-1-GM, a GM-CSF Overexpressing Breast Cancer Cell Line: Intellectual Property and Immune Markers of Response

Autor: Markus D. Lacher, Charles L. Wiseman, Alexander Kharazi, Vivekananda G. Sunkari, Jacqueline L. Galeas, Vito Dozio, Hind Hashwah, Eva Macúchová, William V. Williams

Publikováno v: Recent Patents on Anti-Cancer Drug Discovery. 18:224-240

Background: SV-BR-1-GM, derived from a patient with grade 2 (moderately differentiated) breast cancer, is a GM-CSF-secreting breast cancer cell line with properties of antigen-presenting cells. SV-BR-1-GM and next-generation versions are covered by s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b9d8bcd3f7cfe2ec3d781a635660f8b
https://doi.org/10.2174/1574892817666220518123331

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Akademický článek

SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes

Autor: Markus D. Lacher, Gerhard Bauer, Brian Fury, Sanne Graeve, Emily L. Fledderman, Tye D. Petrie, Dane P. Coleal-Bergum, Tia Hackett, Nicholas H. Perotti, Ying Y. Kong, William W. Kwok, Joseph P. Wagner, Charles L. Wiseman, William V. Williams

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Targeted cancer immunotherapy with irradiated, granulocyte–macrophage colony-stimulating factor (GM-CSF)-secreting, allogeneic cancer cell lines has been an effective approach to reduce tumor burden in several patients. It is generally assumed that

Externí odkaz: https://doaj.org/article/be434467daf447fe95c59f3f971bd772

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Hormonally Active Contraceptives, Part II: Sociological, Environmental, and Economic Impact

Autor: Kathleen M. Raviele, Lester Ruppersberger, Michael Gaskins, Hanna Klaus, Laura Haynes, William V. Williams, Michael D Manhart, Joel Brind, Angela Lanfranchi, Elvis I Šeman, Gerard Migeon

Publikováno v: Linacre Q

To investigate the sociological, environmental, and economic impact of hormonally active contraceptives, a series of comprehensive literature surveys were employed. Sociological effects are discussed including abortion, exploitation of women, a weake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30579f2027e9389a2eef11f52b98ed4f
https://doi.org/10.1177/00243639211005121

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Abstract CT143: Whole cell antigen presenting immune stimulating cells (Bria-IMT) for the treatment of metastatic breast cancer

Autor: Saranya Chumsri, Minal Barve, Chaitali Nangia, Bonnie L. Guerin, Jarrod Holmes, Karim Mohammed, John Knecht, Shaker Dakhil, William V. Williams, Charles Wiseman, Mingjin Chang, Miguel Lopez-Lago, John G. Knecht, Kendrith Rowland, Ralph V. Boccia, Giuseppe Del Priore, Carmen Calfa

Publikováno v: Cancer Research. 83:CT143-CT143

Background: Bria-IMT (SV-BR-1-GM) is an off-the-shelf whole tumor cell therapeutic vaccine engineered to express class I & class II HLAs, secrete GM-CSF, and function as antigen-presenting cells; with subsequent enhancements improving in-vitro charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::daa3e1f041ddd4123a31bb317c2d118c
https://doi.org/10.1158/1538-7445.am2023-ct143

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Abstract 304: Micronuclei in circulating stromal cells correlates with PD-L1 expression and predicts progression in metastatic breast cancer

Autor: Dimpal M. Kasabwala, Massimo Cristofanilli, R. Katherine Alpaugh, Saranya Chumsri, Carolina Reduzzi, Cha-Mei Tang, Rena G. Lapidus, Giuseppe Del Priore, William V. Williams, Daniel L. Adams

Publikováno v: Cancer Research. 83:304-304

Background: Micronuclei (MN) are a result of biological DNA repair mechanisms which form due to internal chromosomal aberrations indicating sub-clonal cancer populations with higher cell survivability and drug therapy resistance. MN are often observe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f08d40d711257bfb71f06f4da195ffe
https://doi.org/10.1158/1538-7445.am2023-304

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Abstract PS17-20: Response to a modified whole tumor cell targeted immunotherapy in patients with advanced breast cancer correlates with tumor grade

Autor: Jarrod P. Holmes, Shaker R. Dakhil, Vivek G Sunkari, Jason Lukas, Markus D. Lacher, William V. Williams, Elizabeth Tan-Chiu, Charles L. Wiseman, Carmen Calfa, George E. Peoples, Saveri Bhattacharya

Publikováno v: Cancer Research. 81:PS17-20

Background: SV-BR-1-GM is a GM-CSF transfected breast cancer cell line, exceptional for having antigen-presenting capability and expressing both HLA I and II. The parent cell line, SV-BR-1, was derived from a patient with grade II (moderately differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36cb70bbeffaef1fae3a6d775f80b7b8
https://doi.org/10.1158/1538-7445.sabcs20-ps17-20

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Abstract P3-09-08: Efficacy and safety of a modified whole tumor cell targeted immunotherapy in patients with advanced breast cancer alone and in combination with immune checkpoint inhibitors

Autor: Markus D. Lacher, Vivek G Sunkari, Shaker R. Dakhil, Charles L. Wiseman, Diane DaSilva, Saveri Bhattacharya, Carmen Calfa, Ajay Kundra, George E. Peoples, Jarrod P. Holmes, William V. Williams, Daniel L. Adams

Publikováno v: Cancer Research. 80:P3-09

Background: SV-BR-1-GM is a GM-CSF transfected breast cancer cell line, exceptional for having antigen-presenting capability expressing both HLA I and II. We report clinical efficacy, safety, and immunologic correlates of response from our initial Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bedcd7882a7b25b05a5d132b14da7290
https://doi.org/10.1158/1538-7445.sabcs19-p3-09-08

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