Zobrazeno 1 - 10
of 173
pro vyhledávání: '"William Tzu-Liang Chen"'
Autor:
Kevin Chih-Yang Huang, William Tzu-Liang Chen, Jia-Yi Chen, Chien-Yueh Lee, Chia-Hsin Wu, Chia-Ying Lai, Pei-Chen Yang, Ji-An Liang, An‑Cheng Shiau, K. S. Clifford Chao, Tao-Wei Ke
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Although irradiated induced-pluripotent stem cells (iPSCs) as a prophylactic cancer vaccine elicit an antitumor immune response, the therapeutic efficacy of iPSC-based cancer vaccines is not promising due to their insufficient antigenicity a
Externí odkaz:
https://doaj.org/article/f7f837b5bb3344b482c12fb402089cc0
Autor:
Kevin Chih-Yang Huang, Tao-Wei Ke, Chia-Ying Lai, Wei-Ze Hong, Hsin-Yu Chang, Chien-Yueh Lee, Chia-Hsin Wu, Shu-Fen Chiang, Ji-An Liang, Jhen-Yu Chen, Pei-Chen Yang, William Tzu-Liang Chen, Eric Y. Chuang, K.S. Clifford Chao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116958- (2024)
The therapeutic efficacy of immunotherapy is limited in the majority of colorectal cancer patients due to the low mutational and neoantigen burdens in this immunogenically “cold” microsatellite stability-colorectal cancer (MSS-CRC) cohort. Here,
Externí odkaz:
https://doaj.org/article/8ae011ff13d845e9af1d8e8f1de4e7c2
Autor:
Kevin Chih-Yang Huang, Shu-Fen Chiang, Pei-Chun Lin, Wei-Ze Hong, Pei-Chen Yang, Hui-Ping Chang, Shin-Lei Peng, Tsung-Wei Chen, Tao-Wei Ke, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα-mediated PANX1 cleavage was essential for ATP release in response to chemother
Externí odkaz:
https://doaj.org/article/9b94d1b51f6c4247a382ea20f1a4efd8
Autor:
Ji-An Liang, Hsin-Yu Chang, Kevin Chih-Yang Huang, Shu-Fen Chiang, Wei-Ze Hong, Jhen-Yu Chen, Pei-Chih Lee, Tao-Wei Ke, Shin-Lei Peng, An‑Cheng Shiau, Tsung-Wei Chen, Pei-Chen Yang, William Tzu-Liang Chen, K S Clifford Chao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Cancer-intrinsic type I interferon (IFN-I) production triggered by radiotherapy (RT) is mainly dependent on cytosolic double-stranded DNA (dsDNA)-mediated cGAS/STING signaling and increases cancer immunogenicity and enhances the antitumor
Externí odkaz:
https://doaj.org/article/04f35a576e1d4e42ae0eae914b4b76f6
Autor:
Kevin Chih-Yang Huang, Tao-Wei Ke, Jia-Yi Chen, Wei-Ze Hong, Shu-Fen Chiang, Chia-Ying Lai, Tsung-Wei Chen, Pei-Chen Yang, Liang-Chi Chen, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Regional lymph node metastasis is an important predictor for survival outcome and an indicator for postoperative adjuvant chemotherapy in patients with colorectal cancer. Even with advances in adjuvant chemotherapeutic regimens, 5-year dista
Externí odkaz:
https://doaj.org/article/805466ca437449f18933c47295fdf9dd
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPatients with metastatic colorectal cancer (mCRC) who are refractory to two or more lines of systemic chemotherapy have limited therapeutic options. The aim of this study was to evaluate the effect of autologous dendritic cell cytokine-indu
Externí odkaz:
https://doaj.org/article/b44ae3726c384dd48e6ae1930eb63c73
Autor:
Yi-Chang Chen, Yuan-Yao Tsai, Sheng-Chi Chang, Hung-Chang Chen, Tao-Wei Ke, Abe Fingerhut, William Tzu-Liang Chen
Publikováno v:
World Journal of Emergency Surgery, Vol 17, Iss 1, Pp 1-10 (2022)
Abstract Introduction Laparoscopic colectomy is rarely performed for ischemic colitis. The aim of this propensity score-matched study was to compare preoperative characteristics, intraoperative details and short-term outcomes for emergent laparoscopi
Externí odkaz:
https://doaj.org/article/edcedb06eadd48e1813944db40f00d38
Autor:
Kevin Chih-Yang Huang, Shu-Fen Chiang, Hsin-Yu Chang, William Tzu-Liang Chen, Pei-Chen Yang, Tsung-Wei Chen, Ji-An Liang, An‑Cheng Shiau, Tao-Wei Ke, K. S. Clifford Chao
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-12 (2022)
Abstract Radiotherapy (RT) mainly elicits antitumor immunity via the cGAS/STING axis for type I interferon (IFN) production. However, dysregulation of cGAS/STING constrains radiotherapy-induced antitumor immunity and type I IFN-dependent cell death a
Externí odkaz:
https://doaj.org/article/30fde6c7ddcd43b5a24c83e8815e09b7
Autor:
Fung Joon Foo, Leonard Ming Li Ho, Winson Jianhong Tan, Frederick H. Koh, Sharmini Su Sivarajah, Soo Yeun Park, William Tzu-Liang Chen, Min Hoe Chew
Publikováno v:
Asian Journal of Surgery, Vol 45, Iss 5, Pp 1095-1100 (2022)
Summary: Purpose: The COVID-19 pandemic has put tremendous strain on healthcare systems. Surgical societies worldwide have advised minimizing non-essential surgeries in order to preserve hospital resources. Given the medical resources and COVID-19 in
Externí odkaz:
https://doaj.org/article/b6d4d31c7c1d49adb559948e76c34b83
Publikováno v:
BMC Surgery, Vol 22, Iss 1, Pp 1-5 (2022)
Abstract Background There is still no consensus on the management of intraperitoneal anastomotic leakage after colonic surgery. Among of various treatment strategies, laparoscopic redo anastomosis for intraperitoneal leakage has rarely been reported
Externí odkaz:
https://doaj.org/article/5bd23c2f760b405dbe94defcc5c6c43e