Zobrazeno 1 - 10
of 15
pro vyhledávání: '"William Tunnicliffe"'
Autor:
Ranjit Lall, Patrick Hamilton, Duncan Young, Claire Hulme, Peter Hall, Sanjoy Shah, Iain MacKenzie, William Tunnicliffe, Kathy Rowan, Brian Cuthbertson, Chris McCabe, Sallie Lamb, on behalf of the OSCAR collaborators
Publikováno v:
Health Technology Assessment, Vol 19, Iss 23 (2015)
Background: Patients with the acute respiratory distress syndrome (ARDS) require artificial ventilation but this treatment may produce secondary lung damage. High-frequency oscillatory ventilation (HFOV) may reduce this damage. Objectives: To determi
Externí odkaz:
https://doaj.org/article/8cba0241774d40e1a59a717088cb957e
Autor:
Peter McGuigan, Margaret McFarland, Cliona McDowell, Jacqui Thompson, Manu Shankar-Hari, John G. Laffey, Phil Hopkins, Cecilia O'Kane, Gerard F. Curley, Ellen Gorman, Colette Jackson, Gavin D. Perkins, Daniel F. McAuley, Mike Clarke, William Tunnicliffe, Jon Smythe, Jonathan A Silversides, Jamie McFerran, Roisin Boyle, Barry Williams, Anna Krasnodembskaya, Christina Campbell
Publikováno v:
EClinicalMedicine, Vol 41, Iss, Pp 101167-(2021)
EClinicalMedicine
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine-published by THE LANCET, vol. 41, 101167 . https://doi.org/10.1016/j.eclinm.2021.101167
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine, vol. 41 . https://doi.org/10.1016/j.eclinm.2021.101167
EClinicalMedicine
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine-published by THE LANCET, vol. 41, 101167 . https://doi.org/10.1016/j.eclinm.2021.101167
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine, vol. 41 . https://doi.org/10.1016/j.eclinm.2021.101167
Background Mesenchymal stromal cells (MSCs) may be of benefit in acute respiratory distress syndrome (ARDS) due to immunomodulatory, reparative, and antimicrobial actions. ORBCEL-C is a population of CD362 enriched umbilical cord-derived MSCs. The RE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625418f3f74bca4d6af1f31458d3a812
http://www.sciencedirect.com/science/article/pii/S2589537021004478
http://www.sciencedirect.com/science/article/pii/S2589537021004478
Autor:
Christina Campbell, Mike Clarke, Ellen Gorman, John G. Laffey, Jacqui Thompson, Phil Hopkins, Gavin D. Perkins, Colette Jackson, Daniel F. McAuley, Jonathan A Silversides, Cliona McDowell, Peter J. McGuigan, Jon Smythe, Gerard F. Curley, Roisin Boyle, Barry Williams, William Tunnicliffe, Jamie McFerran, Margaret McFarland, Manu Shankar-Hari, Cecilia O'Kane
Publikováno v:
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, O'Kane, C & McAuley, D F 2020, ' Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial ', Trials, vol. 21, no. 1, pp. 462 . https://doi.org/10.1186/s13063-020-04416-w, https://doi.org/10.1186/s13063-020-04416-w
Trials
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Trials
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Objectives The primary objective of the study is to assess the safety of a single intravenous infusion of Mesenchymal Stromal Cells (MSCs) in patients with Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Secondary objectives are to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1909d111bf99c230386793115843632e
https://pure.qub.ac.uk/en/publications/repair-of-acute-respiratory-distress-syndrome-by-stromal-cell-administration-in-covid19-realistcovid19-a-structured-summary-of-a-study-protocol-for-a-randomised-controlled-trial(55ff62aa-2ee8-4509-ae9a-bc9b72c12388).html
https://pure.qub.ac.uk/en/publications/repair-of-acute-respiratory-distress-syndrome-by-stromal-cell-administration-in-covid19-realistcovid19-a-structured-summary-of-a-study-protocol-for-a-randomised-controlled-trial(55ff62aa-2ee8-4509-ae9a-bc9b72c12388).html
Autor:
Tamas Szakmany, Ashley Agus, Redmond P Tully, Michael A. Gillies, Gavin D. Perkins, William Tunnicliffe, Jonathan Bannard-Smith, Daniel Brodie, David A Harrison, Daniel F. McAuley, Andrew J. Boyle, Duncan Young, Cliona McDowell, Andrew Bentley, Nicholas A Barrett, James J. McNamee, Colette Jackson, Jonathan E Millar
Publikováno v:
REST Investigators 2021, ' Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure : The REST Randomized Clinical Trial ', JAMA, vol. 326, no. 11, pp. 1013-1023 . https://doi.org/10.1001/jama.2021.13374
McNamee, J J, Gillies, M A, Barrett, N A, Perkins, G D, Tunnicliffe, W, Young, D, Bentley, A, Harrison, D A, Brodie, D, Boyle, A J, Millar, J E, Szakmany, T, Bannard-Smith, J, Tully, R P, Agus, A, McDowell, C & Jackson, C & McAuley, D F 2021, ' Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure : The REST Randomized Clinical Trial ', Journal of the American Medical Association . https://doi.org/10.1001/jama.2021.13374
McNamee, J J, Gillies, M A, Barrett, N A, Perkins, G D, Tunnicliffe, W, Young, D, Bentley, A, Harrison, D A, Brodie, D, Boyle, A J, Millar, J E, Szakmany, T, Bannard-Smith, J, Tully, R P, Agus, A, McDowell, C & Jackson, C & McAuley, D F 2021, ' Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure : The REST Randomized Clinical Trial ', Journal of the American Medical Association . https://doi.org/10.1001/jama.2021.13374
Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.Objective: To determine whether lowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05193bfb001aeb15acb0a4f8de44c270
https://doi.org/10.1001/jama.2021.13374
https://doi.org/10.1001/jama.2021.13374
Publikováno v:
Chest. 152:181-193
ARDS is associated with poor clinical outcomes, with a pooled mortality rate of approximately 40% despite best standards of care. Current therapeutic strategies are based on improving oxygenation and pulmonary compliance while minimizing ventilator-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72dbe1616ad9286e90dc0d1fe0fb4ba
https://doi.org/10.1016/j.chest.2017.02.019
https://doi.org/10.1016/j.chest.2017.02.019
Autor:
Cliona McDowell, William Tunnicliffe, Mark J.D. Griffiths, James J. McNamee, Michael A. Gillies, Andrew Bentley, Stephen J. Brett, Daniel Brodie, Gavin D. Perkins, David A Harrison, Timothy S. Walsh, Alain Vuylsteke, A Gordon, Daniel F. McAuley, Duncan Young, Nicholas A Barrett, Andrew Bodenham, Simon J. Finney, Ashley Agus, Matt P. Wise, Colette Jackson, R Beale, Christine McNally
Publikováno v:
Journal of the Intensive Care Society. 18:159-169
One of the few interventions to demonstrate improved outcomes for acute hypoxaemic respiratory failure is reducing tidal volumes when using mechanical ventilation, often termed lung protective ventilation. Veno-venous extracorporeal carbon dioxide re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d36653645ba8265ee693ad32ac2753b
https://doi.org/10.1177/1751143716681035
https://doi.org/10.1177/1751143716681035
Autor:
William Tunnicliffe, Brendan G. Cooper
Publikováno v:
Foundations of Respiratory Medicine ISBN: 9783319941257
This chapter has been written by two clinicians with immense experience in the measurement and interpretation of lung function testing; one a physician and one a physiologist, but both extremely passionate about educating others in understanding lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819ab1b29b7da40ba6f9cd6ff4be0235
https://doi.org/10.1007/978-3-319-94127-1_2
https://doi.org/10.1007/978-3-319-94127-1_2
Autor:
William Tunnicliffe, Fang Gao Smith, Duncan Young, Daniel F. McAuley, Gavin D. Perkins, Simon Gates, Zahid Hussain Khan, Sarah E Lamb
Summary Background In a previous randomised controlled phase 2 trial, intravenous infusion of salbutamol for up to 7 days in patients with acute respiratory distress syndrome (ARDS) reduced extravascular lung water and plateau airway pressure. We ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1131be33d73c5700f561b3ae3e1505e2
https://doi.org/10.1016/s0140-6736(11)61623-1
https://doi.org/10.1016/s0140-6736(11)61623-1
Autor:
William Tunnicliffe, David Stanley
Publikováno v:
Continuing Education in Anaesthesia Critical Care & Pain. 8:95-99
Asthma is a disease of predominantly reversible airway obstruction characterized by a triad of bronchial smooth muscle contraction, airway inflammation, and increased secretions; it is a major health problem for all age groups. For the majority, cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bada4e7cb235edbdbc4ccb836d1e20a1
https://doi.org/10.1093/bjaceaccp/mkn012
https://doi.org/10.1093/bjaceaccp/mkn012
Autor:
Duncan, Young, Sarah E, Lamb, Sanjoy, Shah, Iain, MacKenzie, William, Tunnicliffe, Ranjit, Lall, Kathy, Rowan, Brian H, Cuthbertson, Judith, Wright
Publikováno v:
The New England journal of medicine. 368(9)
BACKGROUND: Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV) may reduce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d362a5a3298eb000ae2e401e632767
https://pubmed.ncbi.nlm.nih.gov/23745188
https://pubmed.ncbi.nlm.nih.gov/23745188