Zobrazeno 1 - 10
of 27
pro vyhledávání: '"William T. Yewdell"'
Autor:
Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier, Karyn G. Belanger
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes. Swi6 undergoes regulated changes in n
Externí odkaz:
https://doaj.org/article/33ba9aa90faa48488d491651865f3752
Autor:
Wei-Feng Yen, Rahul Sharma, Montserrat Cols, Colleen M. Lau, Ashutosh Chaudhry, Priyanka Chowdhury, William T. Yewdell, Bharat Vaidyanathan, Amy Sun, Maryaline Coffre, Joseph N. Pucella, Chun-Chin Chen, Maria Jasin, Joseph C. Sun, Alexander Y. Rudensky, Sergei B. Koralov, Jayanta Chaudhuri
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1472-1486.e5 (2019)
Summary: The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component of the chromatin remod
Externí odkaz:
https://doaj.org/article/ed2f3bea71bc4f469ef90f6397a16508
Autor:
Whitney L Johnson, William T Yewdell, Jason C Bell, Shannon M McNulty, Zachary Duda, Rachel J O’Neill, Beth A Sullivan, Aaron F Straight
Publikováno v:
eLife, Vol 6 (2017)
Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chr
Externí odkaz:
https://doaj.org/article/51427522d6b74dd39ccd9d4d8de6f023
Autor:
Beatrice Hoyos, Anthony J. Michaels, Alejandra Mendoza, Michail Schizas, Chrysothemis C. Brown, William T. Yewdell, Alexander Y. Rudensky, Jayanta Chaudhuri, Regina Bou-Puerto
Publikováno v:
Sci Immunol
Effective antiviral immunity requires generation of T and B lymphocytes expressing the transcription factor T-bet, a regulator of type 1 inflammatory responses. Using T-bet expression as an endogenous marker for cells participating in a type 1 respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7fb944d3c09771f4486c15d98cac7a
https://europepmc.org/articles/PMC8418793/
https://europepmc.org/articles/PMC8418793/
Autor:
Shan Zha, Ryan M. Smolkin, Bao Q. Vuong, Laura Nicolas, Montserrat Cols, Jayanta Chaudhuri, Keith C. Fernandez, William T. Yewdell, Wei-Feng Yen
Publikováno v:
J Immunol
The DNA damage response protein ATM has long been known to influence class switch recombination in ex vivo–cultured B cells. However, an assessment of B cell–intrinsic requirement of ATM in humoral responses in vivo was confounded by the fact tha
Autor:
William T. Yewdell, Priyanka Chowdhury, Joseph C. Sun, Ashutosh Chaudhry, Montserrat Cols, Amy Sun, Joseph N. Pucella, Bharat Vaidyanathan, Jayanta Chaudhuri, Chun-Chin Chen, Maryaline Coffre, Rahul Sharma, Sergei B. Koralov, Maria Jasin, Colleen M. Lau, Wei-Feng Yen, Alexander Y. Rudensky
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1472-1486.e5 (2019)
Cell reports
Cell reports
SUMMARY The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component of the chromatin remode
Autor:
Ryan M. Smolkin, Anthony J. Michaels, Jayanta Chaudhuri, Montserrat Cols, William T. Yewdell, Kalina T. Belcheva, Davide Angeletti, Alejandra Mendoza, Jonathan W. Yewdell
Publikováno v:
Cell Reports
Summary Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier models or fluorescent p
Autor:
Young Jun Kim, William T. Yewdell, Leena Babiker, Gilbert G. Privé, Amy Chadburn, Yanwen Jiang, Andrew Zhai, David W. Scott, Pedro Farinha, Ari Melnick, Jayanta Chaudhuri, Jude M. Phillip, Daleum Kim, Olivier Elemento, Louis M. Staudt, Ryan D. Morin, Michael D. Nissen, Brian Raught, Christopher R. Chin, Christian Steidl, Tak C. Lee, Wendy Béguelin, Andrew P. Weng, Matt Teater, Michael R. Green, Leandro Venturutti
Publikováno v:
Cell
The most aggressive B-cell lymphomas frequently manifest extranodal distribution, and carry somatic mutations in the poorly-characterized gene TBL1XR1. Here, we show that TBL1XR1 mutations skew the humoral immune response towards generating abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd28257ec2346a76e5d9f59f7e509030
https://europepmc.org/articles/PMC7384961/
https://europepmc.org/articles/PMC7384961/
Autor:
Emily K. Damuth, Karyn G. Belanger, Kenneth D. Belanger, Matthew F. Barber, Mark A. Pettit, Amy N. Russo, William T. Yewdell, Naveen Hussain, Susan J. Geier
The Swi6 protein acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes. Swi6 undergoes regulated changes in nucleocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::385ea7a3011e36117468ac6973c7a28f
https://doi.org/10.1101/2020.06.17.155598
https://doi.org/10.1101/2020.06.17.155598
Autor:
William T. Yewdell, Jayanta Chaudhuri
Publikováno v:
International Immunology. 29:183-196
During an immune response, activated B cells may undergo class switch recombination (CSR), a molecular rearrangement that allows B cells to switch from expressing IgM and IgD to a secondary antibody heavy chain isotype such as IgG, IgA or IgE. Second