Zobrazeno 1 - 10
of 49
pro vyhledávání: '"William T. Triplett"'
Autor:
Rebecca J. Willcocks, Alison M. Barnard, Michael J. Daniels, Sean C. Forbes, William T. Triplett, John F. Brandsema, Erika L. Finanger, William D. Rooney, Sarah Kim, Dah‐Jyuu Wang, Donovan J. Lott, Claudia R. Senesac, Glenn A. Walter, H. Lee Sweeney, Krista Vandenborne
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 1, Pp 67-78 (2024)
Abstract Objective Magnetic resonance (MR) measures of muscle quality are highly sensitive to disease progression and predictive of meaningful functional milestones in Duchenne muscular dystrophy (DMD). This investigation aimed to establish the repro
Externí odkaz:
https://doaj.org/article/4a848dd8b4bb4a98b68cbbe201dd5627
Autor:
Sarah Kim, Rebecca J. Willcocks, Michael J. Daniels, Juan Francisco Morales, Deok Yong Yoon, William T. Triplett, Alison M. Barnard, Daniela J. Conrado, Varun Aggarwal, Ramona Belfiore‐Oshan, Terina N. Martinez, Glenn A. Walter, William D. Rooney, Krista Vandenborne
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1437-1449 (2023)
Abstract Although regulatory agencies encourage inclusion of imaging biomarkers in clinical trials for Duchenne muscular dystrophy (DMD), industry receives minimal guidance on how to use these biomarkers most beneficially in trials. This study aims t
Externí odkaz:
https://doaj.org/article/4d70ad360e114fe3be45ffb256d0e944
Autor:
Alison M Barnard, Rebecca J Willcocks, Erika L Finanger, Michael J Daniels, William T Triplett, William D Rooney, Donovan J Lott, Sean C Forbes, Dah-Jyuu Wang, Claudia R Senesac, Ann T Harrington, Richard S Finkel, Barry S Russman, Barry J Byrne, Gihan I Tennekoon, Glenn A Walter, H Lee Sweeney, Krista Vandenborne
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194283 (2018)
OBJECTIVE:To provide evidence for quantitative magnetic resonance (qMR) biomarkers in Duchenne muscular dystrophy by investigating the relationship between qMR measures of lower extremity muscle pathology and functional endpoints in a large ambulator
Externí odkaz:
https://doaj.org/article/e8dfd05ea09445269c042c5cef248456
Autor:
Alison M Barnard, David W Hammers, William T Triplett, Sarah Kim, Sean C Forbes, Rebecca J Willcocks, Michael J Daniels, Claudia R Senesac, Donovan J Lott, Ishu Arpan, William D Rooney, Richard T Wang, Stanley F Nelson, H Lee Sweeney, Krista Vandenborne, Glenn A Walter
Publikováno v:
Neurology
Background and Objectives:Duchenne muscular dystrophy (DMD) is a progressive muscle degenerative disorder with a well-characterized disease phenotype but considerable interindividual heterogeneity that is not well understood. The aim of the study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bd59c400a798777962bdaf85f08030
https://doi.org/10.1212/wnl.0000000000201163
https://doi.org/10.1212/wnl.0000000000201163
Autor:
Gihan Tennekoon, Maria Cecilia Mancini, Richard S. Finkel, Sabrina W. Yum, Sean C. Forbes, A. Nichols, Joanne M. Donovan, H. Lee Sweeney, Glenn A. Walter, Angelika Fretzen, William T. Triplett, Krista Vandenborne, James MacDougall, Erika Finanger, P. Bista, Rebecca J. Willcocks, Perry B. Shieh, William D. Rooney
Publikováno v:
Neuromuscular Disorders. 31:385-396
Chronic activation of NF-κB is a key driver of muscle degeneration and suppression of muscle regeneration in Duchenne muscular dystrophy. Edasalonexent (CAT-1004) is an orally-administered novel small molecule that covalently links two bioactive com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fa34a107912e09b9d437a015defaf4
https://doi.org/10.1016/j.nmd.2021.02.001
https://doi.org/10.1016/j.nmd.2021.02.001
Autor:
Ann T. Harrington, John F. Brandsema, Glenn A. Walter, Rebecca J. Willcocks, Harneet Arora, Michael J. Daniels, William T. Triplett, Gihan Tennekoon, Krista Vandenborne, Claudia R. Senesac, Erika Finanger, H. Lee Sweeney, Alison M. Barnard, Donovan J. Lott, William D. Rooney, Sean C. Forbes, Dah Jyuu Wang, Umar Alabasi
Publikováno v:
Radiology
BACKGROUND: Upper extremity MRI and proton MR spectroscopy are increasingly considered to be outcome measures in Duchenne muscular dystrophy (DMD) clinical trials. PURPOSE: To demonstrate the feasibility of acquiring upper extremity MRI and proton ((
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f308dc946b30fa57f404285eb7254d08
https://doi.org/10.1148/radiol.2020192210
https://doi.org/10.1148/radiol.2020192210
Autor:
William T. Triplett, Sean C. Forbes, Barry S. Russman, Claudia R. Senesac, G. Tennekoon, Harneet Arora, Rebecca J. Willcocks, Erika Finanger, Michael J. Daniels, Dah Jyuu Wang, Richard S. Finkel, William D. Rooney, Yosef A. Berlow, Elliott O'Brien, Donovan J. Lott, Saptarshi Chakraborty, Brendan Moloney, Alison M. Barnard, Krista Vandenborne, H. Lee Sweeney, Ishu Arpan, Glenn A. Walter
Publikováno v:
Neurology
ObjectiveTo quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles.MethodsMRI and magnetic resonance spectroscopy (MRS) biomarkers were acquired from 104 participants with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3801c2c1126305e4799fbcff5f53a6ac
https://doi.org/10.1212/wnl.0000000000009244
https://doi.org/10.1212/wnl.0000000000009244
Autor:
Rebecca J. Willcocks, Alison M. Barnard, Ryan J. Wortman, Claudia R. Senesac, Donovan J. Lott, Ann T. Harrington, Kirsten L. Zilke, Sean C. Forbes, William D. Rooney, Dah-Jyuu Wang, Erika L. Finanger, Gihan I. Tennekoon, Michael J. Daniels, William T. Triplett, Glenn A. Walter, Krista Vandenborne
Publikováno v:
J Neuromuscul Dis
Background: Joint contractures are common in boys and men with Duchenne muscular dystrophy (DMD), and management of contractures is an important part of care. The optimal methods to prevent and treat contractures are controversial, and the natural hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6e8403247af5ae280303c8b5186f09
https://europepmc.org/articles/PMC9257436/
https://europepmc.org/articles/PMC9257436/
Autor:
Krista Vandenborne, Rebecca J. Willcocks, Glenn A. Walter, William D. Rooney, Alison M. Barnard, Michael J. Daniels, William T. Triplett, Barbara K. Smith, Abhinandan Batra, Sean C. Forbes, Donovan J. Lott
Publikováno v:
Chest
BACKGROUND: Expiratory muscle weakness and impaired airway clearance are early signs of respiratory dysfunction in Duchenne muscular dystrophy (DMD), a degenerative muscle disorder in which muscle cells are damaged and replaced by fibrofatty tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef45a18f938ff13e9c50dff4b581e274
https://europepmc.org/articles/PMC9160975/
https://europepmc.org/articles/PMC9160975/
Autor:
Abhinandan Batra, Krista Vandenborne, William T. Triplett, Barbara K. Smith, Glenn A. Walter, Rebecca J. Willcocks, Donovan J. Lott, Samuel L. Riehl, Sean C. Forbes, Alison M. Barnard
Publikováno v:
J Neurol
OBJECTIVE: Duchenne muscular dystrophy (DMD) is characterized by damage to muscles including the muscles involved in respiration. Dystrophic muscles become weak and infiltrated with fatty tissue, resulting in progressive respiratory impairment. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3648842dd4b78edb067b1ad69bd09f6
https://doi.org/10.1007/s00415-019-09481-z
https://doi.org/10.1007/s00415-019-09481-z